CRISPR (/ˈkrɪspər/) (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic...
152 KB (16,267 words) - 04:20, 10 July 2024
CRISPR gene editing (pronounced /ˈkrɪspər/ "crisper") standing for "Clustered Regularly Interspaced Short Palindromic Repeats" is a genetic engineering...
150 KB (17,442 words) - 04:07, 8 July 2024
CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. It was one of the first companies formed to utilize...
11 KB (918 words) - 14:13, 19 April 2024
CRISPR activation (CRISPRa) is a type of CRISPR tool that uses modified versions of CRISPR effectors without endonuclease activity, with added transcriptional...
21 KB (2,672 words) - 22:49, 25 April 2024
Anti-CRISPR (Anti-Clustered Regularly Interspaced Short Palindromic Repeats or Acr) is a group of proteins found in phages, that inhibit the normal activity...
32 KB (3,691 words) - 12:05, 22 March 2024
Cas9 (redirect from CRISPR/Cas9)
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense...
43 KB (5,610 words) - 21:17, 2 May 2024
CRISPR RNA or crRNA is a RNA transcript from the CRISPR locus. CRISPR-Cas (clustered, regularly interspaced short palindromic repeats - CRISPR associated...
10 KB (1,149 words) - 06:02, 17 June 2024
He Jiankui affair (redirect from CRISPR baby)
standard in vitro fertilisation services and in addition, use of CRISPR gene editing (CRISPR/Cas9), a technology for modifying DNA. The embryos' genomes were...
103 KB (11,583 words) - 04:44, 19 June 2024
CRISPR-Display (CRISP-Disp) is a modification of the CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats) system for genome editing...
16 KB (2,133 words) - 12:04, 22 March 2024
CRISPR interference (CRISPRi) is a genetic perturbation technique that allows for sequence-specific repression of gene expression in prokaryotic and eukaryotic...
24 KB (2,898 words) - 12:08, 22 March 2024
February 19, 1964) is an American biochemist who has pioneered work in CRISPR gene editing, and made other fundamental contributions in biochemistry and...
68 KB (5,876 words) - 16:06, 17 June 2024
Genome-wide CRISPR-Cas9 knockout screens aim to elucidate the relationship between genotype and phenotype by ablating gene expression on a genome-wide...
55 KB (6,164 words) - 23:47, 3 December 2023
The CRISPR Journal is a peer-reviewed scientific journal published every three months by Mary Ann Liebert. It covers research on all aspects of CRISPR research...
2 KB (78 words) - 13:18, 23 April 2024
(gRNAs) for use with the CRISPR/Cas gene editing system. The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR associated nucleases)...
15 KB (1,247 words) - 20:27, 12 May 2024
diagnostic tests using CRISPR-Cas12a and CRISPR-based therapies using its proprietary ultra-small CRISPR systems. Several CRISPR-Cas systems identified...
7 KB (685 words) - 06:53, 23 April 2024
thereby preventing the CRISPR locus from being targeted and destroyed by the CRISPR-associated nuclease. In a bacterial genome, CRISPR loci contain "spacers"...
12 KB (1,421 words) - 00:22, 14 December 2022
Cas12a (redirect from CRISPR/Cas12a)
(CRISPR associated protein 12a, previously known as Cpf1) is a subtype of Cas12 proteins and an RNA-guided endonuclease that forms part of the CRISPR system...
13 KB (1,530 words) - 12:46, 22 March 2024
Genome editing (section CRISPR)
meganucleases—were selected by Nature Methods as the 2011 Method of the Year. The CRISPR-Cas system was selected by Science as 2015 Breakthrough of the Year. As...
78 KB (9,362 words) - 17:41, 2 July 2024
Francisco Mojica (section The discovery of CRISPR)
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). These were later developed into the first widespread genome editing tool, CRISPR-Cas9...
20 KB (1,955 words) - 15:49, 15 October 2023
Guide RNA (section CRISPR In Prokaryotes)
used for gene editing. In bacteria and archaea, gRNAs are a part of the CRISPR-Cas system that serves as an adaptive immune defense that protects the organism...
30 KB (3,628 words) - 09:00, 14 May 2024
technologies such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9), are also improving the nutrition, taste and yield of crops. There...
32 KB (3,581 words) - 18:18, 6 July 2024
CRISPR-associated transposons or CASTs are mobile genetic elements (MGEs) that have evolved to make use of minimal CRISPR systems for RNA-guided transposition...
14 KB (1,712 words) - 03:10, 1 July 2024
Gene drive (section CRISPR)
organism's DNA along with the CRISPR-Cas9 machinery. When the modified organism mates and its DNA mixes with that of its mate, the CRISPR-Cas9 tool cuts the partner's...
47 KB (5,127 words) - 10:04, 8 June 2024
Designer baby (section CRISPR/Cas9)
homology directed repair. The CRISPR/Cas9 system (CRISPR – Clustered Regularly Interspaced Short Palindromic Repeats, Cas9 – CRISPR-associated protein 9) is...
71 KB (8,210 words) - 04:47, 10 July 2024
on pooled genetic perturbation screens. Perturb-seq combines multiplexed CRISPR mediated gene inactivations with single cell RNA sequencing to assess comprehensive...
21 KB (2,588 words) - 18:53, 19 April 2024
Human genetic enhancement (section CRISPR/Cas9)
benefits of revolutionary tools like CRISPR are endless. For example, because it can be applied directly in the embryo, CRISPR/Cas9 reduces the time required...
95 KB (10,492 words) - 19:12, 4 July 2024
Emmanuelle Charpentier (section CRISPR/Cas9)
Chemistry "for the development of a method for genome editing" (through CRISPR). This was the first science Nobel Prize ever won by two women only. Born...
43 KB (3,304 words) - 18:24, 27 June 2024
Germline mutation (section CRISPR/Cas9 editing)
initiates cellular repair processes, similar to that of CRISPR/Cas9 DNA editing. Compared to CRISPR/Cas9, the therapeutic applications of this technology...
25 KB (3,088 words) - 10:40, 1 June 2024
Site-directed mutagenesis (redirect from CRISPR mutagenesis)
alternative to site-directed mutagenesis. Since 2013, the development of the CRISPR/Cas9 technology, based on a prokaryotic viral defense system, has also allowed...
25 KB (2,980 words) - 04:14, 22 June 2024
a nonprofit scientific research institute founded by Nobel laureate and CRISPR gene editing pioneer Jennifer Doudna and biophysicist Jonathan Weissman...
36 KB (3,288 words) - 19:38, 18 May 2024