Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous...
29 KB (3,392 words) - 19:09, 24 June 2024
Apoptotic caspases are subcategorised as: Initiator Caspases (Caspase 2, Caspase 8, Caspase 9, Caspase 10) Executioner Caspases (Caspase 3, Caspase 6 and...
28 KB (3,115 words) - 20:28, 7 September 2024
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues...
35 KB (4,330 words) - 02:13, 24 June 2024
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals...
20 KB (2,278 words) - 19:10, 24 June 2024
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation...
35 KB (3,948 words) - 06:00, 10 June 2024
Apoptosis (redirect from Caspase-mediated cell death)
of caspases: initiator caspases (caspases 2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires...
91 KB (10,653 words) - 17:23, 6 September 2024
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
21 KB (2,394 words) - 03:59, 17 June 2024
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. CASP6 orthologs have been identified in numerous mammals for which complete genome...
13 KB (1,632 words) - 03:48, 19 August 2024
Survivin (section Interaction with caspase-3 and -7)
inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed...
62 KB (8,387 words) - 20:48, 11 August 2024
form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and...
6 KB (669 words) - 19:11, 24 June 2024
a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen, which contains...
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DFFA (redirect from Inhibitor of caspase-activated DNase)
fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA...
11 KB (1,405 words) - 12:00, 5 July 2023
purification of proteins from apoptotic cells since it is cleaved by Caspase-3 and / or Caspase-7 after its sequence DVPD, causing it to lose its immunoreactivity...
5 KB (493 words) - 16:09, 9 August 2024
acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive...
13 KB (1,469 words) - 19:11, 24 June 2024
Caspase-activated DNase (CAD) or DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene. It breaks up the DNA during...
25 KB (3,047 words) - 19:09, 24 June 2024
XIAP (category EC 6.3.2)
disease type 2. XIAP has been shown to interact with: ALS2CR2, Caspase 3. Caspase 7, Caspase-9, Diablo homolog HtrA serine peptidase 2, MAGED1, MAP3K2, TAB1...
22 KB (2,630 words) - 03:36, 16 December 2023
the activation of caspase-9 through the formation of the apoptosome. Once caspase-9 is activated, it can cleave and activate caspase-3 resulting in cell...
24 KB (2,638 words) - 00:26, 29 August 2024
Murine caspase-11, and its human homologs caspase-4 and caspase-5, are mammalian intracellular receptor proteases activated by TLR4 and TLR3 signaling...
11 KB (1,388 words) - 00:36, 3 January 2024
kinases and c-Jun N-terminal kinases. It induces caspase-8 and caspase-9, which results in caspase-3 activation and poly(adp-ribose) polymerases cleavage...
26 KB (2,766 words) - 00:37, 15 May 2024
elegans CED-4, participates in cytochrome c-dependent activation of caspase-3". It identified and reconstituted the mitochondrial pathway to apoptosis...
12 KB (1,598 words) - 09:38, 22 June 2024
recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events...
30 KB (3,914 words) - 10:11, 24 June 2024
Granzyme (category EC 3.4.21)
activates apoptosis by activating caspases (especially caspase-3), which cleaves many substrates, including caspase-activated DNase to execute cell death...
14 KB (1,786 words) - 13:08, 2 June 2024
characterized by the activation of endogenous endonucleases, particularly the caspase-3 activated DNase (CAD), with subsequent cleavage of nuclear DNA into internucleosomal...
20 KB (2,222 words) - 04:09, 5 February 2024
While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo...
25 KB (3,085 words) - 18:04, 14 July 2024
CARD (domain) (redirect from Caspase recruitment domain)
Caspase recruitment domains, or caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically...
15 KB (1,429 words) - 20:45, 30 May 2024
caspase activation, particularly caspase-3. Oligonuclosomal DNA fragmentation is initiated by caspase-activated deoxyribonuclease following caspase-3...
7 KB (1,082 words) - 19:09, 20 February 2023
called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and...
2 KB (168 words) - 22:42, 24 June 2024
mutated or improperly regulated. Many of these inhibitors act to block caspases, a family of cysteine proteases that play an integral role in apoptosis...
13 KB (1,572 words) - 12:11, 13 September 2024
and releases the caspases which leads to the activation of caspase 3. This initiator caspase may cause the cleaving of inactive caspase 3, causing it to...
55 KB (6,757 words) - 17:12, 15 July 2024
Activated DNase (ICAD). During apoptosis, the apoptotic effector caspase, caspase 3, cleaves ICAD and thus causes CAD to become activated. CAD cleaves...
12 KB (1,498 words) - 02:31, 5 February 2024