A chromosomal fragile site is a specific heritable point on a chromosome that tends to form a gap or constriction and may tend to break when the cell is...

Gardner A, Venter D, Baker E, Richards RI (Sep 2000). "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D...

Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by mild-to-moderate intellectual disability. The average IQ in males with...

Causal fermion systems, a fundamental physics theory Chromosomal fragile site, a part of the chromosome prone to breakage Chronic fatigue syndrome, a chronic...

simple crossover model, the two homologous chromosomes overlap on or near a common Chromosomal fragile site (CFS). This leads to a double-strand break...

gene with brain-specific expression and also maps to an unstable chromosomal fragile site. The large gene instability hypothesis puts the DNA damage mechanism...

expression in the posterior fin bud. This enhancer is located near a chromosomal fragile site—a sequence of DNA that is likely to be broken and thus more likely...

neighbouring chromosomes. Minisatellites have been associated with chromosome fragile sites and are proximal to a number of recurrent translocation breakpoints...

structures are present in higher density within and surrounding chromosomal fragile sites, which are segments of DNA that experience replication stress...

FMR1 (Fragile X Messenger Ribonucleoprotein 1) is a human gene that codes for a protein called fragile X messenger ribonucleoprotein, or FMRP. This protein...

accumulation of extra copies of DNA or chromosomes, chromosomal translocations, chromosomal inversions, chromosome deletions, single-strand breaks in DNA...

Causes include the following: Losses from translocation Chromosomal crossovers within a chromosomal inversion Unequal crossing over Breaking without rejoining...

which protect the ends of chromosomal DNA from degradation. Repetitive elements are enriched in the middle of chromosomes as well. Centromeres are the...

The human gene Chromosome 3 open reading frame 14 is a gene of uncertain function located at 3p14.2 near fragile site FRBA3—which falls between this gene...

Professor in 2017. While at WCH, Sutherland's principal focus was on chromosomal fragile sites. Large family studies of genetic diseases revealed unexpected...

yeast and mammalian cells. Most bacterial chromosomes are circular and contain a single origin of chromosomal replication (oriC). Bacterial oriC regions...

isolation of specific chromosomal regions, Nelson et al. identified chromosomal locations of large fragments of the human X chromosome; Nelson contributed...

the Rankin et al., Strul et al., and Hsaio et al., the inherently fragile chromosome was stabilized by discovering the necessary autonomously replicating...

Fragile site, 5-azacytidine type, common, fra(1)(q12) is a protein that in humans is encoded by the FRA1J gene. "Human PubMed Reference:". National Center...

Prominent trinucleotide repeat disorders include Fragile X syndrome and Huntington's disease. In the case of Fragile X syndrome it is thought that the symptoms...

multiple kinetochores dispersed along the entire chromosomal axis, such that microtubules bind to the chromosome along its entire length and move broadside...

Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome) FRA10AC1: Fragile site, folic acid type FRAT1: WNT signaling pathway regulator FRAT2: WNT signaling...

trisomy Xp3 X chromosome, trisomy Xpter Xq13 X chromosome, trisomy Xq X chromosome, trisomy Xq25 X fragile site folic acid type Xanthic urolithiasis Xanthine...

excision repair, cross-linking, alkali-labile sites, point mutations, and structural and numerical chromosomal aberrations. The compromised integrity of the...

disability due to their XX chromosomes. This disability arises from a mutation at the end of the X chromosome in the FMR1 gene (Fragile X Mental Retardation...

involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations...

is also known as FMR2 (Fragile Mental Retardation 2) after this condition. This gene is located on the long arm of chromosome X (Xq27.3-Xq28) It has 22...

used to isolate specific cell populations. B chromosome Chromosomal duplication Isochromosome Marker chromosome Polyploidy Rieger, R.; Michaelis, A.; Green...

Fragile site, folic acid type, rare, fra(2)(q13) is a protein that in humans is encoded by the FRA2B gene. "Human PubMed Reference:". National Center for...

Basics | Wisconsin State Laboratory of Hygiene". "ISCN rules for listing chromosomal rearrangements". Current Protocols in Human Genetics. Appendix 4: Appendix...