The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors...

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors...

Secretin receptor family (class B GPCR subfamily) consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. The family...

5-HT2B, the second HIV co-receptor, C-C chemokine receptor type 5 (CCR5) and the first structure of a non-class A GPCR, the transmembrane domain of the human...

A GPCR oligomer is a protein complex that consists of a small number (ὀλίγοι oligoi "a few", μέρος méros "part, piece, component") of G protein-coupled...

Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein receptors with a broad distribution in embryonic and larval cells...

known superfamily members include the rhodopsin-like GPCRs (this family), the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors...

receptors (GPCRs) that span the cell membrane. Signaling molecules bind to a domain of the GPCR located outside the cell, and an intracellular GPCR domain...

ligand binding cleft. In contrast to the conservative structure of other class C GPCR receptors, the CaSR cleft is an allosteric or co-agonist binding site...

a cysteine-rich domain (CRD). The canonical activation mechanism of class C GPCRs follows a multiple-step process that requires communication between...

Class GPCRs". IUPHAR/BPS Guide to PHARMACOLOGY Database. University of Edinburgh / International Union of Basic and Clinical Pharmacology. "Class C Orphans...

GPR156 were characterized by using cryogenic electron microscopy. Among class C GPCR family members, GPR156 is unique because it lacks a large extracellular...

glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved...

acid receptor 1 (HCA1), which is a Gi/o-coupled G protein-coupled receptor (GPCR). In industry, lactic acid fermentation is performed by lactic acid bacteria...

receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane...

protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing...

activation. The term "protein kinase C" usually refers to the entire family of isoforms. The different classes of PKCs found in jawed vertebrates originate...

The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes. As the vertebrate superfamily can be phylogenetically...

on-off switch for the activation of G-protein. When ligands bind a GPCR, the GPCR acquires GEF (guanine nucleotide exchange factor) ability, which activates...

inhibits the activity of the carrier molecule, Na-K-ATPase pump. The widest class of drugs act as ligands that bind to receptors that determine cellular effects...

receptors (GPCRs). Neuropeptide-GPCRs fall into two families: rhodopsin-like and the secretin class.  Most peptides activate a single GPCR, while some...

pathways, such as β-arrestin signaling. In addition to GPCRs, arrestins bind to other classes of cell surface receptors and a variety of other signaling...

vertebrates, these receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene...

Retrieved 8 December 2020. Congreve M, Marshall F (March 2010). "The impact of GPCR structures on pharmacology and structure-based drug design". British Journal...

G-protein coupled receptors (GPCR), and membrane fluidity have all been shown to be affected by steroid hormones. Of these, GPCR linked proteins are the most...

Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends in Pharmacological Sciences. 26 (5): 274–281. doi:10.1016/j...

protein-coupled receptor (GPCR) that regulates brain catecholamine systems. Activation of TAAR1 increases cyclic adenosine monophosphate (cAMP) production and...

the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which...

receptor-ligand system. These systems typically utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic ligands, like clozapine N-oxide...

GPCR neuropeptide receptors are G-protein coupled receptors which bind various neuropeptides. Members include: Neuropeptide B/W receptor NPBWR1 NPBWR2...