Cofactor engineering, a subset of metabolic engineering, is defined as the manipulation of the use of cofactors in an organism’s metabolic pathways. In...

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases...

i th row and j th column. This number is often denoted Mi,j. The (i, j) cofactor is obtained by multiplying the minor by ( − 1 ) i + j {\displaystyle (-1)^{i+j}}...

carboxylase). An example of an enzyme that contains a cofactor is carbonic anhydrase, which uses a zinc cofactor bound as part of its active site. These tightly...

switching the iron-protoporphyrin cofactor in thermostable P450 enzyme CYP119A1 with an iridium-methyl-protoporphyrin cofactor (Ir(Me)-PIX), followed by directed...

Another computing method, IPRO, successfully engineered the switching of cofactor specificity of Candida boidinii xylose reductase. Iterative Protein Redesign...

{\displaystyle F_{x'}} are sometimes called the positive and negative Shannon cofactors, respectively, of F {\displaystyle F} with respect to x {\displaystyle...

congenital cofactor deficiency. A congenital molybdenum cofactor deficiency disease, seen in infants, is an inability to synthesize molybdenum cofactor, the...

Nicotinamide cofactor analogues (mNADs), also called nicotinamide coenzyme biomimetics (NCBs), are artificial compounds that mimic the natural nicotinamide...

(biotin and thiamine) are organosulfur compounds crucial for life. Many cofactors also contain sulfur, including glutathione, and iron–sulfur proteins....

enzymes for which vitamin C is a cofactor, with function potentially compromised in a deficiency state, and any enzyme cofactor or other physiological function...

tons of nicotinamide were sold in 2014. Nicotinamide, as a part of the cofactor nicotinamide adenine dinucleotide (NADH / NAD+) is crucial to life. In...

hydroxylase enzymes performing these reactions require vitamin C as a cofactor, a long-term deficiency in this vitamin results in impaired collagen synthesis...

proteins, however, generate and maintain a superoxidized form of the flavin cofactor, the flavin-N(5)-oxide. Flavoproteins were first discovered in 1879 by...

bacteria, but the production pathway requires the cofactor NADPH, whereas E. coli makes the cofactor NADH. To circumvent this problem, she evolved the...

contains a pigmented prosthetic group (or cofactor). A common example is haemoglobin, which contains a heme cofactor, which is the iron-containing molecule...

molecule: as an electron transporter, an oxygen carrier, and as an enzyme cofactor, heme binding proteins have consistently attracted the attention of protein...

the function of citrulline as part of the nitric oxide cycle. It is a cofactor and acts on glutathione peroxidase. Glutathione is used to produce S-sulfanylglutathione...

and 3'-phosphates. NADP, a dinucleotide enzymatic cofactor. FAD, a dinucleotide enzymatic cofactor in which one of the ribose sugars adopts a linear configuration...

P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases. However,...

groups (Types I, II, III, IV, and V) based on their composition and enzyme cofactor requirements, the nature of their target sequence, and the position of...

called hyperphenylalaninemia is caused by the inability to synthesize a cofactor called tetrahydrobiopterin, which can be supplemented. Pregnant women with...

that cleaves the DNA palindromic sequence AAGCTT in the presence of the cofactor Mg2+ via hydrolysis. The cleavage of this sequence between the AA's results...

metabolism. Fritz Lipmann won the Nobel Prize in 1953 for his discovery of the cofactor coenzyme A. Acetyl-CoA is a metabolic intermediate that is involved in...

Although this reaction requires nicotinamide adenine dinucleotide (NAD) as a cofactor, the enzymic mechanism regenerates it, resulting in the net use of no NAD...

being most abundant of those. Metal cofactors are bound tightly to specific sites in proteins; although enzyme cofactors can be modified during catalysis...

cyclic adenosine monophosphate), and are incorporated into important cofactors of enzymatic reactions (coenzyme A, flavin adenine dinucleotide, flavin...

This determinant can be computed using Sarrus's rule or cofactor expansion. Using Sarrus's rule, it expands to a × b = ( a 2 b 3 i + a 3...

volatile compounds when mixed with glucose and amino acids at 90 °C. It is a cofactor in tyrosine oxidation. The main use of l-ascorbic acid and its salts is...

from a tetraketide derived from 4-coumaroyl CoA. p-Coumaric acid is a cofactor of photoactive yellow proteins (PYP), a homologous group of proteins found...