DEPDC5 (or DEP domain-containing 5) is a human protein of poorly understood function but has been associated with cancer in several studies. It is encoded...
16 KB (1,368 words) - 22:32, 21 August 2024
mutations associated with FCD2a and FCD 2b include MTOR, PI3KCA, AKT3, and DEPDC5. Mutations in these genes lead to enhanced mTOR pathway signaling at critical...
7 KB (712 words) - 17:20, 2 August 2024
Q5TB30 4188 DEPDC1B HGNC:24902 Q8WUY9 4189 DEPDC4 HGNC:22952 Q8N2C3 4190 DEPDC5 HGNC:18423 O75140 4191 DEPDC7 HGNC:29899 Q96QD5 4192 DEPP1 HGNC:23355 Q9NTK1...
277 KB (17 words) - 19:37, 1 October 2024
DEPDC5, NPRL2, NPRL3, PRIMA1, CABP4, CRH and others. In some cases, structural and genetic etiologies can coexist such as with mutations in DEPDC5. The...
15 KB (1,611 words) - 10:54, 4 September 2023
at least two highly conserved complexes: the "GATOR1" complex containing DEPDC5, NPRL2 and NPRL3 and the ""GATOR2" complex containing Mios, WDR24, WDR59...
69 KB (7,807 words) - 19:19, 19 September 2024
well as GATOR1. Additionally, C12orf66 is predicted to interact with KRAS, DEPDC5, and C7orf60. These interactions were detected by high throughput affinity...
15 KB (1,320 words) - 22:53, 2 December 2023
ascribed to Nprl3 to date is as part of the GATOR1 complex (with NPRL2 and DEPDC5) that inhibits the mechanistic target of rapamycin (mTOR) kinase-complex-1...
5 KB (648 words) - 14:22, 31 May 2023