In biochemistry, the DNA methyltransferase (DNA MTase, DNMT) family of enzymes catalyze the transfer of a methyl group to DNA. DNA methylation serves a...
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include protein methyltransferases, DNA/RNA methyltransferases, natural product methyltransferases, and non-SAM dependent methyltransferases. SAM is the classical...
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spontaneous deamination of cytosine. DNA methylation as well as many of its contemporary DNA methyltransferases have been thought to evolve from early...
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Epigenetics (section DNA methylation)
−21 and +8 after DNA repair was allowed. At least four articles report the recruitment of DNA methyltransferase 1 (DNMT1) to sites of DNA double-strand breaks...
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Methylated-DNA--protein-cysteine methyltransferase (MGMT), also known as O6-alkylguanine DNA alkyltransferase AGT, is a protein that in humans is encoded...
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DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, a process called...
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DNA adenine methylase, (Dam) (also site-specific DNA-methyltransferase (adenine-specific), EC 2.1.1.72, modification methylase, restriction-modification...
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Site-specific DNA-methyltransferase may refer to: Site-specific DNA-methyltransferase (adenine-specific) Site-specific DNA-methyltransferase (cytosine-N4-specific)...
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DNMT1 (redirect from DNA -methyltransferase 1)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called...
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Transcription (biology) (redirect from DNA transcription)
P, Jeltsch A (December 2019). "H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction"...
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DNA adenine methyltransferase identification, often abbreviated DamID, is a molecular biology protocol used to map the binding sites of DNA- and chromatin-binding...
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after DNA repair was allowed.[citation needed] At least four articles report the recruitment of DNA methyltransferase 1 (DNMT1) to sites of DNA double-strand...
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DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency...
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Hypomethylating agent (redirect from DNA methyltransferase inhibitor)
available hypomethylating agents block the activity of DNA methyltransferase (DNA methyltransferase inhibitors / DNMT inhibitors). Currently two members...
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Site-specific DNA-methyltransferase (cytosine-N4-specific) (EC 2.1.1.113, modification methylase, restriction-modification system, DNA[cytosine-N4]methyltransferase...
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N6AMT1 (redirect from N-6 adenine-specific DNA methyltransferase 1)
adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene. The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase...
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Restriction enzyme (redirect from Dna restriction-modification enzymes)
up foreign DNA in a process called restriction digestion; meanwhile, host DNA is protected by a modification enzyme (a methyltransferase) that modifies...
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Neoplasm (section DNA damage)
et al. (May 2013). "Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal...
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JSTOR 25665289. PMC 2872463. PMID 20351277. Jin B, Robertson KD (2013). "DNA Methyltransferases, DNA Damage Repair, and Cancer". Epigenetic Alterations in Oncogenesis...
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as a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase inhibitor. "Prescription medicines: registration of new generic...
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Methylation (section O-methyltransferases)
methylmercury. DNA methylation is the conversion of the cytosine to 5-methylcytosine. The formation of Me-CpG is catalyzed by the enzyme DNA methyltransferase. In...
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Cancer cell (section DNA repair and mutation)
O-6-methylguanine-DNA methyltransferase is observed in several different kinds of cancer (see Wikipedia article O-6-methylguanine-DNA methyltransferase). Although...
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bound to DNA and blocking its DNA methyltransferase function. In addition, the covalent protein adduction also compromises the functionality of DNA and triggers...
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Cancer epigenetics (section DNA methylation)
In cancer cells "global hypomethylation" due to disruption in DNA methyltransferases (DNMTs) may promote mitotic recombination and chromosome rearrangement...
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is an orphan DNA methyltransferase, that is involved in controlling gene expression in most Alphaproteobacteria. This enzyme modifies DNA by catalyzing...
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can also be methylated into 5-methylcytosine by an enzyme called DNA methyltransferase or be methylated and hydroxylated to make 5-hydroxymethylcytosine...
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This occurs via phase variation of a single DNA methyltransferase. Phase variation of methyltransferase expression results in differential methylation...
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Myelodysplastic syndrome (section DNA damage)
cytopenias. The recently approved DNA methyltransferase inhibitors take advantage of this mechanism by creating a more orderly DNA methylation profile in the...
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hypomethylates DNA by inhibiting DNA methyltransferase. It functions in a similar manner to azacitidine, although decitabine can only be incorporated into DNA strands...
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adenosine. DNA methyltransferases are inhibited by SAH. Two S-adenosyl-L-homocysteine cofactor products can bind the active site of DNA methyltransferase 3B and...
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