DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, a process called...

intellectual disability syndrome caused by autosomal dominant mutations in the DNMT3A gene. The syndrome was first recognized in 2014 by Katrina Tatton-Brown...

(DNMT1, DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a maintenance methyltransferase, DNMT3A and DNMT3B...

of splicing factor genes. Mutation of DNMT3A contributes to development of hematologic malignancies, and DNMT3A-mutated cell lines exhibit transcriptome...

identified in mammals. They are named DNMT1, two isoforms transcribed from the DNMT3a gene: DNMT3a1 and DNMT3a2, and DNMT3b. Recently, another enzyme DNMT3c has...

splicing factor genes. Mutation of DNMT3A has been demonstrated to contribute to hematologic malignancies, and that DNMT3A-mutated cell lines exhibit transcriptome...

methyltransferases (DNMTs). There are 5 DNMTs in humans: DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L, and in algae and fungi 3 more are present (DNMT4, DNMT5...

recommendations. The prognostic importance of other mutated genes (e.g., DNMT3A, IDH1, IDH2) is less clear. Elevated lactate dehydrogenase level were also...

(DNMT1, DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a “maintenance” methyltransferase, DNMT3A and DNMT3B...

family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B. This enzyme is responsible for maintaining DNA methylation...

DNA. There is further crosstalk between DNA methylation carried out by DNMT3A and DNMT3B and histone methylation so that there is a correlation between...

cleave unmethylated DNA at all. Mammalian DNA-methyltransferases DNMT1, DNMT3a and DNMT3b catalyze a reaction of DNA methylation. DNMT1 maintains DNA methylation...

hematopoiesis. Many of these fall into the categories of epigenetic regulators (DNMT3a, TET2, and ASXL1), signaling proteins (JAK2), spliceosome components (SF3B1...

Myc has been shown to interact with: ACTL6A BRCA1 Bcl-2 Cyclin T1 CHD8 DNMT3A EP400 GTF2I HTATIP let-7 MAPK1 MAPK8 MAX MLH1 MYCBP2 MYCBP NMI NFYB NFYC...

nicotine dependency. DNMT3B has been shown to interact with: CBX5, DNMT1, DNMT3A, KIF4A, NCAPG, SMC2, SUMO1 and UBE2I. GRCh38: Ensembl release 89: ENSG00000088305...

and cancer. The ablation of DNMT3A leads to an increase in HSC self-renewal and a decrease in differentiation. DNMT3A mutations contribute heavily to...

chromatin and prevent the activation of cryptic start sites. In mammals, DNMT3a and DNMT3b PWWP domain binds to H3K36me3 and the two enzymes are recruited...

nucleus, where it can be transcribed. DNMT1 recruits other DNMTs, including DNMT3A and DNMT3B, which, as a complex, recruit HDAC1. This complex adds methyl...

hypermethylation, which may have been induced by the overexpression of DNMT3a. Klotho may be a reliable gene for early detection of methylation changes...

involved in chromatin assembly. ZNF238 has been shown to interact with DNMT3A. GRCh38: Ensembl release 89: ENSG00000179456 – Ensembl, May 2017 GRCm38:...

anthracyclines family. Studies have shown that in DNA methyltransferase 3A (DNMT3A) the most frequent mutation is seen at arginine 882 (DNMT3AR882). This mutation...

L; Shank, K; Martinez, A B V; Rivera, S A; et al. (29 December 2015). "Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic...

second mechanism involves DNMT3A2, a splice-isoform of DNA methyltransferase DNMT3A, which adds methyl groups to cytosines in DNA. This isoform is induced by...

HGNC:29125 Q9UQ16 4447 DNMBP HGNC:30373 Q6XZF7 4448 DNMT1 HGNC:2976 P26358 4449 DNMT3A HGNC:2978 Q9Y6K1 4450 DNMT3B HGNC:2979 Q9UBC3 4451 DNMT3L HGNC:2980 Q9UJW3...

site-specific DNA methylation. By fusing the DNMT3a catalytic domain with the dCas9 protein, dCas9-DNMT3a is capable of achieving targeted DNA methylation...

mice, cows, hamsters, and humans. It has also been shown that DNMT1 and DNMT3a decrease with aging and DNMT3b increases. Hypomethylation of DNA can lower...

alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle". Environmental Health Perspectives...

and is mediated through the activity of DNA methyltransferases (DNMTs). DNMT3A and DNMT3B regulate de novo methylation of CpG sites, while DNMT1 maintains...

caused by HBx recruiting the DNA methyltransferase enzymes, DNMT1 and/or DNMT3A, to specific gene loci to alter their methylation levels and gene expression...

hippocampus expression of the gene-repressive DNA methylating enzymes DNMT1, DNMT3a and DNMT3b. The hippocampus has important functions in memory, spatial navigation...