H3K27me3 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the tri-methylation of lysine 27 on histone...

marks on histone 3 lysine 4 (H3K4me3) and histone 3 lysine 27 (H3K27me3). The H3K27me3 mark silences the gene while the H3K4me3 mark allows the gene to...

Active Promoters Active Enhancers Transcribed Gene Bodies Silenced Regions H3K4me3 H3K4me1 H3K36me3 H3K27me3 H3K27ac H3K27ac H3K9me3...

changes include histone modifications, such as histone H3 methylation (i.e. H3K27me3 by PRC2 which is recruited by Xist) and histone H2A ubiquitination, as...

methyltransferase activity and primarily methylates histone H3 on lysine 27 (i.e. H3K27me3), a mark of transcriptionally silent chromatin. PRC2 is required for initial...

Peak calling representation for H3K27me3 targeted sequencing results, comparing CUT&RUN to traditional ChIP. Here CUT&RUN appears to deliver improved signal-to-noise...

posttranslational modification with epigenetic effects: H3K27ac, an acetylation H3K27me3, a tri methylation This article includes a list of related items that share...

treatment. The definitive genetic marker of a diffuse midline glioma is H3K27me3 loss. Diffuse midline gliomas have three known subtypes: H3K27M: Referred...

Peak calling representation for H3K27me3 targeted sequencing results, comparing CUT&RUN to traditional ChIP. Note That CUT&RUN and CUT&Tag appears to deliver...

UTX-1, a H3K27me3 demethylase, plays a critical role in the aging of C.elegans: increased utx-1 expression correlates with a decrease in H3K27me3 and a decrease...

particularly associated with repressed genes: Trimethylation of H3 lysine 27 (H3K27me3) This histone modification is deposited by the polycomb complex PRC2. It...

novo missense mutation in EED was associated with decreased levels of H3K27me3 in comparison to wild type. This decrease was linked to loss of PRC2 activity...

the production of BMI1, a component of the PcG complex that recognizes H3K27me3. This occurs in a Gli-dependent manner, as Gli1 and Gli2 are downstream...

genes and H3K4me3 is highly enriched at promoters and in poised genes. H3K27me3, H4K20me1 and H3K4me1 silence transcription in embryonic fibroblasts, macrophages...

methyltransferase Dot1L, and the H3K27me3 methyltransferase EZH2/PRC2. He went on to demonstrate the function of H3K27me3 methylation in X chromosome inactivation...

genome. Example protein to immunoprecipitate are histone modifications (H3K27me3, H3K4me2, H3K9me3, etc.), Polycomb-group protein (PRC2:Suz12, PRC1:YY1)...

Chromatin profiles DNA methylation H3K4me2 H3K9me3 H3K27me3 FSHD1 ↓ ↑ ↓ FSHD2* ↓ ↑ ↓ ↑ *Chromatin profiles not fully characterized for DNMT3B mutation...

associated with transcriptional activity, whereas H3K9me2, H3K9me3, H3K27me2, H3K27me3, and H4K20me3 are associated with transcriptional repression. Modifications...

attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2". Clin Epigenetics. 15 (1): 12. doi:10...

cells, also share similar epigenetic patterns. For example, H3K4me3 and H3K27me3, are two major histone methylation patterns that form a bivalent domain...

understanding of cell-specific gene regulation. Since the H3K27ac and H3K27me3 modification is at the same location on the histone tail, they antagonize...

per homologs pair. Bivalent gene is a gene marked with both H3K4me3 and H3K27me3 epigenetic modification in the same area of this kind and is proposed to...

to direct the trimethylation of lysine 9 (H3K9me3) and 27 of histone 3 (H3K27me3) to an imprinting centre that overlaps the Kcnqot1 promoter and actually...

regulators of NF-κB. Demethylation of DNA packaging protein Histone H3 (H3K27me3) can lead to up-regulation of genes controlling SASP. mTOR (mammalian target...

functions. H3K4me3-promoters H3K4me1- primed enhancers H3K36me3-gene bodies H3K27me3-polycomb repression H3K9me3-heterochromatin The human genome was annotated...

histone H3 K27M mutations and loss of nuclear K27-trimethylated histone H3 (H3K27me3) to identify H3 K27M-mutant diffuse midline gliomas. Treatment for brain...

H3K9me2 -repression H3K9me3 is found in constitutively repressed genes. H3K27me3 is found in facultatively repressed genes. H3K36me H3K36me2 H3K36me3 is...

bivalent chromatin, H3K4me3 is co-localized with the repressive modification H3K27me3 to control gene regulation. H3K4me3 in embryonic cells is part of a bivalent...

modifications. Proliferative genes may show increases in the repressive mark H3K27me3 while genes involved in silencing or aberrant histone products may be enriched...

trimethylation of H3K27me3 in regions containing developmental genes appears to be important for maintenance of normal cell differentiation. H3K27me3 is also important...