H3K9me2 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the di-methylation at the 9th lysine residue...

to cocaine. This depends on ΔFosB inhibiting G9a gene expression, i.e. H3K9me2 synthesis which in turn inhibits transcription factors for ΔFosB. For this...

conditioning in rats. However, dimethylation of histone H3 at lysine 9 (H3K9me2), a signal for transcriptional silencing, is increased after exposure to...

Tri-methylation of lysine 9 are associated with repression and heterochromatin (see H3K9me2 and H3K9me3), while mono-methylation of K4 (K4 corresponds to lysine residue...

2010; Sun et al., 2012a). Such drug-induced downregulation of G9a and H3K9me2 also sensitizes animals to the deleterious effects of subsequent chronic...

on histone modification in the nucleus accumbens. They suggest that the H3K9me2 modification in this area of the brain plays a role in the stress and depression...

di-methylated states of histone H3 at lysine residue 9 (i.e., H3K9me1 and H3K9me2) and lysine residue 27 (H3K27me1 and H3K27me2). The presence of H3K9me1/2...

sites in the absence of PRC2. Di and tri-methylation of H3 lysine 9 (H3K9me2/3) H3K9me2/3 is a well-characterised marker for heterochromatin, and is therefore...

2010; Sun et al., 2012a). Such drug-induced downregulation of G9a and H3K9me2 also sensitizes animals to the deleterious effects of subsequent chronic...

dimethylation (H3K9me2) and blocks the induction of ΔFosB-mediated neural and behavioral plasticity by chronic drug use, which occurs via H3K9me2-mediated repression...

dimethylation (H3K9me2) and blocks the induction of ΔFosB-mediated neural and behavioral plasticity by chronic drug use, which occurs via H3K9me2-mediated repression...

dimethylation (H3K9me2) and blocks the induction of ΔFosB-mediated neural and behavioral plasticity by chronic drug use, which occurs via H3K9me2-mediated repression...

Glp are knocked out in vivo, global levels of H3K9me2 are severely reduced and are equivalent to H3K9me2 levels in G9a and Glp double knockout mice. Therefore...

feedback loops between H3K9me2 and the RdDM and CMT2/3 DNA methylation pathways fulfill a similar function in propagating H3K9me2. More recently, a plant-specific...

to cocaine. This depends on ΔFosB inhibiting G9a gene expression, i.e. H3K9me2 synthesis which in turn inhibits transcription factors for ΔFosB. For this...

2010; Sun et al., 2012a). Such drug-induced downregulation of G9a and H3K9me2 also sensitizes animals to the deleterious effects of subsequent chronic...

siRNAs and interacts with the methylated lysine 9 residue of histones H3 (H3K9me2) is the RITS complex. RITS was discovered in the fission yeast Schizosaccharomyces...

primed enhancers H3K4me3 is enriched in transcriptionally active promoters. H3K9me2 -repression H3K9me3 is found in constitutively repressed genes. H3K27me3...

to cocaine. This depends on ΔFosB inhibiting G9a gene expression, i.e. H3K9me2 synthesis which in turn inhibits transcription factors for ΔFosB. For this...

transcript variants. KDM3A catalyzes the demethylation of H3K9me1 and H3K9me2 residues. Its function is dependent on the presence of cofactors Fe(II)...

sensitivity overall. There was an increase in G9a expression and its product H3K9me2 when a nerve injury occurred. A chromatin-immunoprecipitation assay showed...

modifications of histones (H3K4me2 and H3K9me2), H3K4 demethylase lysine-specific demethylase 1 (LSD1), and an H3K9me2 methyltransferase SET domain bifurcated...

target genes by recruiting the PKMT G9a-like protein (GLP), which catalyzes H3K9me2 and leads to chromatin silencing and gene repression. In response to stimulation...

Mechtler K, Kowalski JR, Hamon CA, Kelly TA, Jenuwein T (2007). "Reversal of H3K9me2 by a small molecule inhibitor for the G9a histone methyltransferase". Molecular...

the microarray data on GEO database of NCBI, it can be found that the H3K9me2 methyltransferase G9a depletion can increase the expression amount of c1orf110...

KDM4A, KDM4B and KDM4C demethylate H3K9me2/3, H3K9me3 and H3K36me2/3, and KDM4D, KDM4E and KDM4F demethylate H3K9me2/3. KDM4A, KDM4B, KDM4C and KDM4D have...

prominent example is the increased repressive methylation of histone 3 (H3K9me2), which has been associated with both age of disease onset and treatment...

Abbondanza C, Avvedimento EV (January 2008). "DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression". Science. 319 (5860):...

methyltransferase G9a. G9a then catalyzes repressive histone 3 lysine 9 dimethylation (H3K9me2) at promoter sites of target genes of MyoD. G9a also methylates MyoD, which...