factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription...
19 KB (2,321 words) - 13:56, 24 December 2023
DCs, whereas IRF8 is essential for CD8α + DCs. In addition to IRF4 and IRF8, IRF1 and IRF2 are also involved in DC subset development. IRF8 has also been...
10 KB (1,098 words) - 23:10, 30 March 2024
suggest that fluorine might react with iridium hexafluoride at 39 GPa to form IrF8. CRC Handbook of Chemistry and Physics, 90th Edition, CRC Press, Boca Raton...
4 KB (326 words) - 08:10, 27 April 2023
R. (2009). Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature genetics...
6 KB (834 words) - 21:46, 28 December 2023
octafluororhenate(VII) ([ReF8]−), octafluoroiodate(VII) ([IF8]−), octafluoroiridate(VII) ([IrF8]−), and octafluoroxenate(VI) ([XeF8]2−) anions. Riedel, S.; Kaupp, M. (30...
2 KB (214 words) - 14:53, 4 August 2023
IRF4 and IRF8 work in concert to achieve DC differentiation. IRF4 expression is responsible for inducing development of CD4+ DCs, while IRF8 expression...
23 KB (2,598 words) - 17:33, 2 January 2024
ENSG00000185507 IRF Known motif – High-throughput in vitro [432] CGAAAVYGAAANY IRF8 ENSG00000140968 IRF Known motif – High-throughput in vitro [433] CGAAACYGAAACY...
374 KB (81 words) - 02:10, 23 September 2023
IRF8: Governing the virtues of B Lymphocytes". Frontiers in Biology. 9 (4): 269–282. doi:10.1007/s11515-014-1318-y. PMC 4261187. PMID 25506356. "IRF8...
67 KB (7,967 words) - 20:38, 20 July 2024
cell development), and Gfi1 (promotes Th2 development and inhibits Th1) or IRF8 (basophils and mast cells). Significantly, certain factors elicit different...
32 KB (3,345 words) - 23:36, 20 July 2024
marrow and in tumors. STAT3 also promotes development of MDSCs, whereas IRF8 could counteract MDSC-inducing signals. MDSCs migrate as immature cells from...
22 KB (2,634 words) - 05:02, 29 April 2024
mutated proteins). Mutations to the transcription factors for BCL6, MEF2B and IRF8, are common in direct transcriptional changes that cause DLBCL. Additionally...
20 KB (2,414 words) - 11:10, 15 July 2024
regulate the development and survival of RPMs, these factors being: Spi-C, IRF8/4, heme oxygenase-1 and M-CSF. RPM's are capable of inducing the differentiation...
8 KB (1,116 words) - 20:42, 14 July 2024
Consortium (2011). "The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study". PLOS ONE. 6 (4):...
19 KB (2,200 words) - 05:21, 25 December 2023
Theofilopoulos, Argyrios N. (February 19, 2013). "Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of...
112 KB (12,093 words) - 09:26, 21 July 2024
AID expression. AID is induced by transcription factors TCF3 (E47), HoxC4, Irf8 and Pax5, and inhibited by PRDM1 (Blimp1) and Id2. At the post-transcriptional...
19 KB (2,473 words) - 09:09, 30 December 2023
HGNC:6120 Q13568 7783 IRF6 HGNC:6121 O14896 7784 IRF7 HGNC:6122 Q92985 7785 IRF8 HGNC:5358 Q02556 7786 IRF9 HGNC:6131 Q00978 7787 IRGC HGNC:28835 Q6NXR0 7788...
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for her contributions to immunogenetics and epigenetics in isolating the IRF8 transcription factor that aids humans in fighting off disease and for identifying...
7 KB (714 words) - 12:22, 14 July 2023
gain-of-function mutation STAT2 deficiency IRF7 deficiency CD16 deficiency IRF8 deficiency IFNAR2 deficiency TLR pathway deficiencies IRAK4 deficiency IRAK1...
19 KB (1,836 words) - 09:52, 5 July 2024
stimulates immune responses in T-cells, a set of non-B-cell lymphocytes; 2) IRF8 (10-50% of cases) which encodes the interferon regulatory factor 8 protein...
20 KB (2,501 words) - 05:27, 3 December 2023
directly and indirectly represses anti-osteoclastogenesis genes such as Bcl6, IRF8, and MafB, helping monocytes differentiate into osteoclasts. In mice, insufficient...
23 KB (2,688 words) - 23:16, 13 February 2024
activity. IRF1 has been shown to interact with: CHIP GAGE HSP70 / HSP90 IRF8 KPNA2 MYD88 PCAF STAT1 TAT VEGFR2 REDD2 IRF2 Interferon regulatory factors...
15 KB (1,827 words) - 03:26, 23 July 2024
subunit of the COP9 signalosome. COPS2 has been shown to interact with: DAX1, IRF8, NIF3L1, and THRA. GRCh38: Ensembl release 89: ENSG00000166200 – Ensembl...
10 KB (1,273 words) - 11:02, 27 March 2024
JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet....
9 KB (1,219 words) - 18:42, 24 April 2024
Chen; Liu, Jianguo; Ning, Huan; Shin, Min Sun (2011). "Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation". Nature Communications...
18 KB (1,611 words) - 16:08, 8 November 2023
cDC1s lineage specification via maintaining Interferon regulatory factor 8 (IRF8) expression. The DC-SCRIPT deficient cDC1s had impaired capacity to capture...
7 KB (880 words) - 15:43, 27 December 2023
K. Subbarao; Geiger, Rechel; Zhu, Qifan; Neale, Geoffrey (3 May 2018). "IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation". Cell...
44 KB (4,323 words) - 10:21, 27 March 2024
super-enhancer-associated genes including the cell identity genes CEBPA and IRF8. Cyclin-dependent kinase 8 has been shown to interact with: CCNC CREB binding...
21 KB (2,557 words) - 01:16, 24 April 2022