Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN)...
22 KB (2,575 words) - 17:56, 23 October 2024
the deubiquitinating protease family of enzymes. It is known to remove ISG15 conjugates from a broad range of protein substrates, a process known as...
18 KB (1,884 words) - 05:57, 26 April 2022
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
15 KB (1,749 words) - 23:12, 13 August 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
29 KB (3,499 words) - 07:16, 20 February 2024
covalent linkage to the Nedd protein ISGylation, the covalent linkage to the ISG15 protein (Interferon-Stimulated Gene 15) pupylation, the covalent linkage...
32 KB (3,131 words) - 03:19, 21 November 2024
cross-reactive protein (UCRP, also known as interferon-stimulated gene-15 ISG15), ubiquitin-related modifier-1 (URM1), neuronal-precursor-cell-expressed...
97 KB (11,029 words) - 03:48, 27 October 2024
E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene. This gene is a member of the HERC family of ubiquitin ligases...
3 KB (404 words) - 20:03, 23 October 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
24 KB (2,755 words) - 04:56, 29 September 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
51 KB (5,551 words) - 15:05, 1 October 2024
signaling (e.g. by mutations in the genes IFNG, IL12B, IL12RB1, IL12RB2, IL23R, ISG15, MCTS1, RORC, TBX21, TYK2, CYBB, JAK1, IFNGR1, IFNGR2, STAT1, USP18, IRF1...
32 KB (3,601 words) - 17:36, 18 September 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
53 KB (6,406 words) - 07:06, 12 November 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
49 KB (5,533 words) - 08:12, 2 November 2024
regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway". PLOS ONE. 6 (1): e16422. Bibcode:2011PLoSO...616422W...
80 KB (10,515 words) - 04:03, 2 November 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
50 KB (5,687 words) - 08:38, 2 November 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
34 KB (4,010 words) - 17:12, 19 August 2024
(2005). "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme". J. Biochem....
6 KB (752 words) - 06:02, 5 January 2024
Zhao C, Denison C, Huibregtse JM, Gygi S, Krug RM (July 2005). "Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins...
23 KB (2,831 words) - 16:57, 27 August 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
27 KB (3,282 words) - 19:22, 20 October 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
34 KB (4,108 words) - 02:42, 22 November 2024
TRIM21 TRIM21 E3 ubiquitin-protein ligase TRIM21 TRIM25 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 TRIM56 TRIM56 E3 ubiquitin-protein ligase TRIM56 TRIM71 TRIM71...
183 KB (12,460 words) - 13:46, 23 September 2024
(2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem....
5 KB (662 words) - 16:51, 23 October 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
10 KB (1,274 words) - 23:14, 6 February 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
21 KB (2,320 words) - 01:38, 14 August 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
24 KB (2,881 words) - 02:41, 16 November 2024
HGNC:28660 Q9BUE6 7797 ISCA2 HGNC:19857 Q86U28 7798 ISCU HGNC:29882 Q9H1K1 7799 ISG15 HGNC:4053 P05161 7800 ISG20 HGNC:6130 Q96AZ6 7801 ISG20L2 HGNC:25745 Q9H9L3...
277 KB (17 words) - 18:41, 6 October 2024
Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene. The modification of proteins with ubiquitin is an...
7 KB (870 words) - 00:54, 4 March 2023
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
76 KB (8,728 words) - 11:37, 6 November 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
13 KB (1,384 words) - 23:04, 9 June 2024
Interferon gamma receptor 2 deficiency Tyk2 deficiency JAK1 loss-of-function ISG15 deficiency RORc deficiency STAT1 deficiency, gain-of-function mutation STAT2...
19 KB (1,836 words) - 09:52, 5 July 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
2 KB (215 words) - 03:26, 28 March 2024