Insulin-degrading enzyme, also known as IDE, is an enzyme. Known alternatively as insulysin or insulin protease, IDE is a large zinc-binding protease of...

normally involves endocytosis of the insulin-receptor complex, followed by the action of insulin-degrading enzyme. An insulin molecule produced endogenously...

insulinase, insulin-degrading enzyme, insulin protease, insulin proteinase, insulin-degrading neutral proteinase, insulin-specific protease, insulin-glucagon...

post-prandial glucose excursion. Amylin is degraded in part by insulin-degrading enzyme. Another long- acting analogue of Amylin is Cagrilintide being...

Joachimiak A, Rosner MR, Tang WJ (October 2006). "Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism". Nature. 443 (7113):...

be degraded by the cell. Degradation normally involves endocytosis of the insulin-receptor complex followed by the action of insulin degrading enzyme. Most...

matrix metalloproteinases, and M16 metalloproteinases such as Insulin Degrading Enzyme and Presequence Protease In the MEROPS database peptidase families...

the response to insulin, the phosphorylation of multiple enzymes, including glycogen synthase, helps control the synthesis or degradation of glycogen and...

being responsible for the recognition and degradation of amyloid beta; these include insulin degrading enzyme and presequence protease. The rate of removal...

Intact dilation and extraction, a form of abortion Insulin-degrading enzyme, Insulysin, an enzyme Infectious disease epidemiology, the study of the patterns...

The insulin transduction pathway is a biochemical pathway by which insulin increases the uptake of glucose into fat and muscle cells and reduces the synthesis...

Digestive enzymes take part in the chemical process of digestion, which follows the mechanical process of digestion. Food consists of macromolecules of...

elements (PPRE). The PPREs influence insulin-sensitive genes, which enhance production of mRNAs of insulin-dependent enzymes. The final result is better use...

IGFBP degrading enzymes, referred to collectively as proteases. The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like...

Saghatelian, A.; Liu, D. R. (2014). "Anti-Diabetic Activity of Insulin-Degrading Enzyme Inhibitors Mediated by Multiple Hormones". Nature. 511 (7507):...

in her bloodstream, the placenta has insulin receptors that stimulate the production of insulin-degrading enzymes which counteract this effect. In Europe...

action of insulin in liver cells. By 1949, he and his team had focused on the enzyme called glucose 6-phosphatase, which is the first crucial enzyme in sugar...

pancreas, provided that the person takes insulin for proper regulation of blood glucose concentration and pancreatic enzyme supplements to aid digestion. The...

status based on data showing that the enzyme was safe. Recombinant human insulin has almost completely replaced insulin obtained from animal sources (e.g...

sugar levels in a glucose-dependent manner by enhancing the secretion of insulin. Beside the insulinotropic effects, GLP-1 has been associated with numerous...

against insulin receptors, called insulin receptor antibodies. The antibodies attach to insulin receptors and prevent insulin breakdown, or degradation, leading...

"Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme". The EMBO Journal. 29 (23): 3952–66. doi:10.1038/emboj.2010.256...

glucagon and insulin resistance from the body. Insulin can no longer inhibit the gene expression of enzymes such as PEPCK which leads to increased levels...

of insulin. Higher concentrations of leucine cause hyperactivity in the mTOR pathway, and S6 kinase is activated leading to inhibition of insulin receptor...

synthesized by other enzymes. Many proteins are involved in the process of cell signaling and signal transduction. Some proteins, such as insulin, are extracellular...

PMID 3534791. Affholter JA, Fried VA, Roth RA (December 1988). "Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease...

In turn, disaccharides are mostly degraded by specific glycosidases to glucose. The names of the degrading enzymes are often derived from the particular...

stimulate the release of insulin. Insulin allows glucose to be taken up and used by insulin-dependent tissues. Thus, glucagon and insulin are part of a feedback...

many pathways to degrade each amino acid when the need for protein synthesis has been met. Mutations in isoleucine-degrading enzymes can lead to dangerous...

taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis...