erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the...
29 KB (3,402 words) - 07:08, 20 May 2024
2020. Monomethyl fumarate alters the NFE2L2 (Nuclear factor erythroid 2-related factor 2) transcription factor. NFE2L2 (or NRF2) is a basic leucine zipper...
7 KB (392 words) - 05:07, 10 July 2024
GW501516 PPAR gamma coactivator 1-alpha estrogen-related receptor γ GSK4716 NFE2L2 Canonical transient receptor potential (TRPC) proteins Myostatin myostatin...
4 KB (392 words) - 20:53, 2 January 2024
class of storage proteins in the endosperm of maize (Zea mays) kernels NFE2L2 or Nrf2 Bzip Maf transcription factors ATF1; ATF2; ATF4; ATF5; ATF6; ATF7;...
7 KB (663 words) - 00:42, 13 March 2024
gain-of-function mutations have been found in oncogenes such as PIK3CA (16%) and NFE2L2 (15%). Common oncogene copy number amplifications have been found in SOX2...
14 KB (1,563 words) - 14:58, 30 October 2023
Q14934 10485 NFE2 HGNC:7780 Q16621 10486 NFE2L1 HGNC:7781 Q14494 10487 NFE2L2 HGNC:7782 Q16236 10488 NFE2L3 HGNC:7783 Q9Y4A8 10489 NFIA HGNC:7784 Q12857...
282 KB (17 words) - 07:55, 20 June 2024
NFE2L1 ENSG00000082641 bZIP Known motif – In vivo/Misc source [593] ATGAYD NFE2L2 ENSG00000116044 bZIP Known motif – In vivo/Misc source [594] VVTGACTMAGCA...
374 KB (81 words) - 02:10, 23 September 2023
production genes (uncoupling protein, UCP; nuclear factor erythroid 2 like 2, NFE2L2) and a dynamics gene (mitofusin 1, MFN1) were upregulated (P < 0.05) at...
32 KB (3,679 words) - 18:58, 13 March 2024
transcription factor nuclear factor erythroid 2-related factor 2 (i.e., NFE2L2 or Nrf2) thereby holding it in the cytosol and unable to enter the cell...
95 KB (11,779 words) - 04:23, 6 July 2024
Collar (CNC) family of proteins. In 1989, the first CNC transcription factor NFE2L2 was identified. Subsequently, several related proteins were identified,...
13 KB (1,547 words) - 04:58, 27 May 2024
basal and luminal subtypes. Basal subtype show alterations involving RB and NFE2L2 and luminal type show changes in FGFR3 and KDM6A genes. Basal subtype are...
130 KB (12,788 words) - 05:06, 8 July 2024
CSNK2A2 DDX21, DDIT3 ERG ETS2, FOSL1 GTF2B MAPK8 MyoD NACA NELFB NFE2L1 NFE2L2 NCOR2 NCOA1 PIN1 RBM39 RELA RB1 RFWD2 RUNX1 RUNX2 SMAD3 STAT1 STAT3 TBP...
45 KB (5,452 words) - 05:07, 13 July 2024
to interact with: CASP8 NMT2 CFLAR DCC GroEL HCLS1 Survivin TRAF3 XIAP NFE2L2 Caspase-3 has been found to be necessary for normal brain development as...
29 KB (3,392 words) - 19:09, 24 June 2024
JS, Kozak LP (Sep 2002). "Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling...
21 KB (2,577 words) - 22:40, 6 April 2024
component of the KEAP1-NFE2L2 protein complex in the cytosol of cells. This negates KEAP1's ability to bind NFE2L2; in consequence, NFE2L2 becomes free to translocate...
66 KB (7,270 words) - 21:47, 16 May 2024
"ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway". Autophagy. 16 (5): 917–931. doi:10...
22 KB (2,346 words) - 11:32, 18 July 2024
Inhibition of mTORC1 has also been shown to increase transcription of the NFE2L2 (NRF2) gene, which is a transcription factor that is able to regulate the...
69 KB (7,803 words) - 11:01, 11 April 2024
induction of the nuclear translocation of erythroid 2–related factor 2 (NFE2L2). The PI3K/Nrf2 pathway signaling triggers several responses, such as the...
17 KB (1,858 words) - 23:20, 15 December 2023
namely CNC (cap 'n' collar) proteins (p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3) – not to be confused with Nuclear Respiratory factors)...
25 KB (3,041 words) - 23:52, 24 January 2024
Wolcott-Rallison syndrome. EIF2AK3 has been shown to interact with DNAJC3, NFE2L2, and endoplasmic reticulum chaperone BiP (Hsp70). GSK2606414 3-Fluoro-GSK2606414...
12 KB (1,365 words) - 06:21, 24 December 2023
gene has been shown to bind: Sp1, NF-κB, AP-1, AP-2, Egr-1, CREB, p53, and NFE2L2. The SOD2 protein has been shown to interact with HIV-1 Tat and HIV-1 Vif...
26 KB (3,223 words) - 21:03, 2 December 2023
as CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). sMafs regulate...
16 KB (1,840 words) - 20:32, 13 May 2024
CFAP298, E2F1, EGFR, HDAC3, HIF1A, IRAK1, KIAA0753. MARK4, MDM2, NDUFA3, NFE2L2, NOTCH1, NUAK1, OPRK1, P53, PCNA PARK2, RIPK1, RPS6KB1, S100A10, SCNN1A...
37 KB (4,261 words) - 21:30, 23 December 2023
anti-oxidant response element (ARE) by forcing cytosolic KEAP1 to release NFE2L2 which then moves to the nucleus, binds ARE, and induces production of, e...
67 KB (7,341 words) - 20:23, 5 April 2024
as CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). sMaf homodimers...
21 KB (2,536 words) - 15:41, 3 December 2023
as CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3)] and Bach proteins (BACH1 and BACH2). sMaf homodimers...
22 KB (2,631 words) - 20:38, 27 December 2023