An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue. This function...
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RANKL (redirect from Osteoclast differentiation factor)
activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by...
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resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in...
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Bone (section Osteoclast)
osteocytes are involved in the formation and mineralisation of bone; osteoclasts are involved in the resorption of bone tissue. Modified (flattened) osteoblasts...
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Giant cell (section Osteoclast)
body. Osteoclasts are frequently classified and discussed separately from other MGCs which are more closely linked with disease. Non-osteoclast MGCs can...
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Bone health (section Osteoclast cells)
New bone is deposited by osteoblast cells and resorbed or destroyed by osteoclast cells. This addition and subtraction of bone usually yields no net change...
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understood. It is postulated that osteoclasts are the cells responsible for the resorption of the root surface. Osteoclasts can break down bone, cartilage...
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Osteoclast stimulatory transmembrane protein is a protein that in humans is encoded by the OCSTAMP gene. GRCh38: Ensembl release 89: ENSG00000149635 –...
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mechanisms. Under normal circumstances, TRAP is highly expressed by osteoclasts, activated macrophages, neurons, and by the porcine endometrium during...
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tumor. It is characterized by the presence of multinucleated giant cells (osteoclast-like cells). Malignancy in giant-cell tumor is uncommon and occurs in...
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Chambers he developed the osteoclast lacunar bone resorption assay system. His work was the first to show that the human osteoclast shares specific surface...
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dysplasias. The cause of the disease is understood to be malfunctioning osteoclasts and their inability to resorb bone. Although human osteopetrosis is a...
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NF-κB ligand (RANKL)–induced osteoclast differentiation. Pepstatin A suppresses the formation of multinuclear osteoclasts dose-dependently. This inhibition...
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increased tubular reabsorption of calcium and activation of osteoclast activity, respectively. Osteoclasts are a type of bone cell which cause bone resorption...
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expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer...
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The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as hyperparathyroidism. They are a form of osteitis fibrosa...
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neutralize excessive existing acid. Hydrochloric acid is also used by osteoclasts alongside proteases for bone resorption. Being a strong acid, hydrochloric...
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factor kappa-Β ligand), which works by decreasing the development of osteoclasts, which are cells that break down bone. It was developed by the biotechnology...
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active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. Although osteoclasts are active during the natural formation...
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responsible for bone metabolism: osteoblasts (which secrete new bone), and osteoclasts (which break bone down). The structure of bones as well as adequate supply...
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the periosteum. To prevent the bone from becoming unnecessarily thick, osteoclasts resorb the bone from the endosteal side. Long bone Netter, Frank H. (1987)...
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Podosome (section Role in osteoclasts)
these dynamic structures such as invadopodia, (invasive cancer cells), osteoclasts, vascular smooth muscle cells, endothelial cells, and certain immune...
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PRDM1 (section Osteoclast development)
of plasma B cells, T cells, dendritic cells (DCs), macrophages, and osteoclasts. Pattern Recognition Receptors (PRRs) can activate BLIMP-1, both as a...
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tumor can be subclassified. Osteosarcomas may exhibit multinucleated osteoclast-like giant cells. X-rays is the initial imaging of choice to diagnose...
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Tartrate-resistant acid phosphatase may be used as a biochemical marker of osteoclast function during the process of bone resorption. The following genes encode...
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osteoblasts creating bone and osteoclasts destroying bone. Bisphosphonates inhibit the digestion of bone by encouraging osteoclasts to undergo apoptosis, or...
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more differentiated myeloid cell types such as monocytes, macrophages, osteoclasts, myeloid dendritic cells, microglia, and Paneth cells. CSF1R expression...
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Under normal conditions, bone undergoes continuous remodeling through osteoclast-mediated bone resorption and osteoblast-mediated bone deposition. These...
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during the differentiation of osteoclast precursor cells into mature osteoclasts, known as osteoclastogenesis. Mature osteoclasts then bind to bone through...
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mechanisms. They destroy bone through a rapid, transient (relative to osteoclasts) mechanism called osteocytic osteolysis. Hydroxyapatite, calcium carbonate...
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