• Thumbnail for P-glycoprotein
    P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family...
    33 KB (3,930 words) - 21:04, 3 September 2024
  • Thumbnail for Glycoprotein
    Glycoproteins are proteins which contain oligosaccharide (sugar) chains covalently attached to amino acid side-chains. The carbohydrate is attached to...
    28 KB (2,653 words) - 04:14, 23 July 2024
  • Thumbnail for ABC transporter
    (MDR) against a variety of structurally unrelated drugs. ABCB1 or MDR1 P-glycoprotein is also involved in other biological processes for which lipid transport...
    111 KB (14,443 words) - 02:35, 30 October 2024
  • Thumbnail for Loperamide
    substrate of P-glycoprotein; therefore, the concentration of loperamide increases when given with a P-glycoprotein inhibitor. Common P-glycoprotein inhibitors...
    47 KB (4,105 words) - 08:17, 22 December 2024
  • Thumbnail for Methylprednisolone
    methylprednisolone clearance. Methylprednisolone is shown to be a substrate of P-glycoprotein; its inhibition is thought to increase methylprednisone absorption and...
    57 KB (5,147 words) - 23:47, 10 December 2024
  • Thumbnail for Ivermectin
    channels. Since drugs that inhibit the enzyme CYP3A4 often also inhibit P-glycoprotein transport, the risk of increased absorption past the blood-brain barrier...
    79 KB (7,691 words) - 05:37, 5 December 2024
  • Thumbnail for Digoxin
    by renal excretion and involves P-glycoprotein, which leads to significant clinical interactions with P-glycoprotein inhibitor drugs. Examples commonly...
    47 KB (4,845 words) - 09:13, 6 October 2024
  • Thumbnail for Escitalopram
    this action is unknown. Escitalopram is a substrate of P-glycoprotein and hence P-glycoprotein inhibitors such as verapamil and quinidine may improve...
    58 KB (5,397 words) - 01:01, 11 December 2024
  • Thumbnail for Rivaroxaban
    and P-glycoprotein inhibitors group. Therefore, it is important to monitor for bleeding when concurrently on rivaroxaban and moderate CYP3A4 and P-glycoprotein...
    29 KB (2,612 words) - 03:54, 20 November 2024
  • Thumbnail for Ondansetron
    Ondansetron may have a degree of peripheral selectivity due to binding to P-glycoprotein and efflux out of the brain at the blood–brain barrier. Ondansetron...
    35 KB (3,196 words) - 04:14, 22 November 2024
  • Thumbnail for Cetirizine
    Theunissen EL, Vermeeren A, van Ruitenbeek P, Stiers P, Mehta MA, et al. (September 2013). "The role of P-glycoprotein in CNS antihistamine effects". Psychopharmacology...
    36 KB (3,344 words) - 08:22, 30 November 2024
  • Thumbnail for Silibinin
    flavonoids, has been shown to inhibit P-glycoprotein-mediated cellular efflux. The modulation of P-glycoprotein activity may result in altered absorption...
    21 KB (2,233 words) - 08:08, 21 August 2024
  • Thumbnail for Colchicine
    from the use of intravenous colchicine. Colchicine interacts with the P-glycoprotein transporter, and the CYP3A4 enzyme involved in drug and toxin metabolism...
    54 KB (5,641 words) - 22:10, 13 December 2024
  • Thumbnail for Olanzapine
    any second-generation antipsychotic towards the P-glycoprotein in one in vitro study. P-glycoprotein transports a myriad of drugs across a number of different...
    97 KB (9,064 words) - 04:04, 17 December 2024
  • Thumbnail for CYP3A4
    erythromycin (although FDA lists it as a moderate inhibitor, and inhibitor of P-glycoprotein, defined as those increasing the AUC of digoxin to ≥1.25-fold); telithromycin...
    80 KB (7,794 words) - 00:31, 3 December 2024
  • Thumbnail for Zosuquidar
    drug. Zosquidir inhibits P-glycoproteins. Other drugs with this mechanism include tariquidar and laniquidar. P-glycoproteins are trans-membrane proteins...
    7 KB (592 words) - 09:08, 15 June 2024
  • Thumbnail for Chemotherapy
    of these pumps, known as p-glycoprotein, in order to protect themselves from chemotherapeutics. Research on p-glycoprotein and other such chemotherapy...
    155 KB (17,519 words) - 02:42, 7 December 2024
  • Thumbnail for Wilfred Stein
    transporter P-glycoprotein, Stein worked out a simple equation for the “leak-pump” mode of action of the drug efflux pump, P-glycoprotein. In collaboration...
    23 KB (2,880 words) - 12:25, 1 July 2024
  • Thumbnail for Blood–brain barrier
    blood–brain barrier. The BBB appears to be functional by the time of birth. P-glycoprotein, a transporter, exists already in the embryonal endothelium. Measurement...
    32 KB (3,679 words) - 23:26, 11 December 2024
  • Thumbnail for Sucralose
    microbiota, increased the pH level in the intestines, contributed to increases in body weight, and increased levels of P-glycoprotein (P-gp). These effects have...
    27 KB (2,800 words) - 17:48, 21 December 2024
  • Thumbnail for Bilastine
    inhibitors or inducers of the P-glycoproteins. Coadministration of bilastine and grapefruit juice (a known P-glycoprotein-mediated drug transport activator)...
    26 KB (2,691 words) - 05:49, 9 December 2024
  • Thumbnail for Pharmacology of bicalutamide
    Bicalutamide, as well as enzalutamide, have been found to act as inhibitors of P-glycoprotein efflux and ATPase activity. This action may reverse docetaxel resistance...
    186 KB (20,584 words) - 09:12, 3 December 2024
  • an increase in the expression of the P-glycoprotein efflux pump. By utilizing agents that inhibit P-glycoprotein activity imatinib susceptibility has...
    56 KB (6,470 words) - 20:27, 19 November 2024
  • Thumbnail for Fluoxetine
    activity of P-glycoprotein, a type of membrane transport protein that plays an important role in drug transport and metabolism and hence P-glycoprotein substrates...
    118 KB (11,757 words) - 21:15, 22 December 2024
  • Thumbnail for Omeprazole
    concomitantly with omeprazole. Omeprazole is also a competitive inhibitor of p-glycoprotein, as are other PPIs. Drugs that depend on an acidic stomach environment...
    42 KB (3,798 words) - 09:41, 26 November 2024
  • initial work with ABC transporters focused on two such transporters, P-glycoprotein and MRP1. This initial work has led to new insights into a mechanism...
    15 KB (1,717 words) - 03:37, 16 September 2024
  • Thumbnail for Risperidone
    Risperidone and its metabolite paliperidone are reduced in efficacy by P-glycoprotein inducers such as St John's wort. Risperidone has been found to dose-dependently...
    56 KB (5,180 words) - 23:03, 5 December 2024
  • Thumbnail for Modafinil
    inhibition of CYP2C9. Modafinil may induce P-glycoprotein, which may affect drugs transported by P-glycoprotein, such as digoxin. It was clinically found...
    181 KB (16,723 words) - 18:35, 17 December 2024
  • Thumbnail for Nintedanib
    substrate of the transporter P-glycoprotein which moves the absorbed substance back into the gut's lumen. The P-glycoprotein inhibitor ketoconazole is known...
    34 KB (3,021 words) - 12:39, 5 August 2024
  • Thumbnail for P-selectin glycoprotein ligand-1
    coding region, and TATA-less promoters. P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric mucin-like glycoprotein found primarily on the surface of white...
    18 KB (2,231 words) - 20:32, 19 November 2024