Pleiotropy (from Greek πλείων pleion, 'more', and τρόπος tropos, 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits...

In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects...

The antagonistic pleiotropy hypothesis (APT) is a theory in evolutionary biology that suggests certain genes may confer beneficial effects early in an...

classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) suggest that environmental factors, such as predation...

putative cause for the broad changes seen in domestication syndrome is pleiotropy. Pleiotropy occurs when one gene influences two or more seemingly unrelated...

the distribution of allelic and mutational effects, and patterns of pleiotropy, dominance, and epistasis. There are several different experimental views...

Strawberry roan, or chestnut roan, is a horse coat color consisting of a mixture of reddish-brown and white hairs in varying proportions, stable over the...

pleiotropy in the interleukin-4/13 system", Cell, 132(2):259-72. Ozaki, K; Leonard, WJ (16 August 2002). "Cytokine and cytokine receptor pleiotropy and...

Such a genetic effect is called the antagonistic pleiotropy effect when referring to a gene (pleiotropy signifying the gene has a double function – enabling...

of mutations (evolution of ageing), disposable soma and antagonistic pleiotropy hypothesis. The molecular theories of ageing include phenomena such as...

A very simple genotype–phenotype map that only shows additive pleiotropy effects....

evolution such as kin selection and inclusive fitness, or antagonistic pleiotropy that favors heterozygotes causing homosexuality among homozygotes as a...

better explained as a by-product of adaptive traits caused by antagonistic pleiotropy and by genes that are retained due to a fitness landscape with an asymmetric...

Biology of Aging exploring a view of the subject based on antagonistic pleiotropy, the hypothesis that aging is caused by genes that have two effects, one...

specification, and adaptation, probably promoted by their low level of pleiotropy. As early as the 1930s, J. B. S. Haldane and others suggested that copies...

would include information about the patient's covariates. Every novel pleiotropy discovery will need further biological validation to ensure that the data-driven...

"Investigating cognitive transfer within the framework of music practice: genetic pleiotropy rather than causality". Developmental Science. 19 (3): 504–512. doi:10...

exposure. This is known as the "exclusion restriction" or "no horizontal pleiotropy" assumption. To ensure that the first core assumption is validated, Mendelian...

There is also a hypothesis that female genital evolution is the result of pleiotropy, i.e. unrelated genes that are affected by environmental conditions like...

Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...

genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and...

Nocebo Patient safety Perioperative mortality Pharmacotoxicology Placebo Pleiotropy (drugs) Polypharmacy Toxicology Edwards, I. Ralph; Aronson, Jeffrey K...

diseases, and sepsis. Glucocorticoids have many diverse effects such as pleiotropy, including potentially harmful side effects. They also interfere with...

and criminality, were hereditary because these traits were subjective. Pleiotropy occurs when one gene influences multiple, seemingly unrelated phenotypic...

Antagonistic pleiotropy is a theory proposed as an alternative by George C. Williams, a critic of Medawar, in 1957. In antagonistic pleiotropy, genes carry...

intersexually pleiotropic. Under the hypothesis of intersexual antagonistic pleiotropy, the benefit males get from EPC cancels out the negative effects of EPC...

between the diseases One disease resulting from complications of another Pleiotropy The factors responsible for the development of comorbidity can be chronic...

Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...

Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...

the genetic influences on a different trait estimating the degree of pleiotropy or causal overlap. A genetic correlation of 0 implies that the genetic...