• Thumbnail for Plexin
    A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon...
    15 KB (1,611 words) - 18:10, 23 May 2024
  • Thumbnail for Plexin A1
    Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene. Plexin A1 has been shown to interact with AKT1. GRCh38: Ensembl release 89: ENSG00000114554...
    6 KB (703 words) - 22:19, 3 March 2023
  • Thumbnail for PLXNB1
    PLXNB1 (redirect from Plexin B1)
    Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene. Within neural tissues, the plexin family serves as transmembrane...
    10 KB (1,248 words) - 07:34, 24 December 2023
  • Thumbnail for Synaptic pruning
    in mice that have a Plexin-A3 defect. Specifically, axons that are connected to a transient target will retract once the Plexin-A3 receptors are activated...
    23 KB (2,972 words) - 02:10, 7 June 2024
  • Thumbnail for Optic chiasm
    (Sema6D) expressed at the midline, which form a complex that signals to Nr-CAM/Plexin-A1 receptors on crossing RGC axons. Since all vertebrates, even the earliest...
    15 KB (1,712 words) - 17:03, 3 July 2024
  • Thumbnail for PLXNA4A
    Plexin-A4 is a protein that in humans is encoded by the PLXNA4 gene. Plexin A4 binds to neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) and transduces signals...
    6 KB (723 words) - 23:59, 3 March 2023
  • Thumbnail for SEMA4D
    induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and...
    10 KB (1,298 words) - 06:50, 24 December 2023
  • receptors are called plexins, with neuropilins as their co-receptors in many cases. The main receptors for semaphorins are plexins, which have established...
    7 KB (870 words) - 07:16, 16 August 2023
  • Thumbnail for PLXND1
    Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene. GRCh38: Ensembl release 89: ENSG00000004399 – Ensembl, May 2017 GRCm38: Ensembl release...
    4 KB (453 words) - 23:20, 20 February 2024
  • Thumbnail for PLXNA3
    Plexin-A3 is a protein that in humans is encoded by the PLXNA3 gene. GRCh38: Ensembl release 89: ENSG00000130827 – Ensembl, May 2017 GRCm38: Ensembl release...
    4 KB (581 words) - 23:07, 4 September 2022
  • Thumbnail for Semaphorin-3A
    Nakamura F, Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99...
    14 KB (1,729 words) - 23:05, 27 March 2024
  • Thumbnail for Rnd1
    (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells"...
    8 KB (955 words) - 17:20, 11 April 2024
  • Thumbnail for Dendrite
    tyrosine kinase receptors, BMP7, Wnt/dishevelled, EPHB 1–3, Semaphorin/plexin-neuropilin, slit-robo, netrin-frazzled, reelin. Rac, CDC42 and RhoA serve...
    24 KB (2,881 words) - 19:34, 13 June 2024
  • Thumbnail for Chromosome 17
    protein ORMDL sphingolipid biosynthesis regulator 3 PLXDC1: encoding protein Plexin domain-containing protein 1 PNPO: encoding enzyme Pyridoxine-5'-phosphate...
    26 KB (1,920 words) - 22:52, 28 March 2024
  • Thumbnail for Neuropilin 1
    Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM (October 1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99...
    16 KB (1,958 words) - 17:08, 8 June 2024
  • Thumbnail for PLXNA2
    Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene. This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins...
    6 KB (773 words) - 06:38, 3 June 2024
  • Thumbnail for PLXNB3
    Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene. PLXNB3 has been shown to interact with ARHGEF11. GRCh38: Ensembl release 89: ENSG00000198753...
    5 KB (657 words) - 20:03, 3 December 2023
  • Thumbnail for Neuropilin
    documented to regulate neurogenesis and angiogenesis by complexing with Plexin receptors/class-3 semaphorin ligands and Vascular Endothelial Growth Factor...
    11 KB (1,055 words) - 03:34, 23 June 2024
  • Thumbnail for PLXDC2
    Plexin domain-containing protein 2 is a protein that in humans is encoded by the PLXDC2 gene. GRCh38: Ensembl release 89: ENSG00000120594 – Ensembl, May...
    3 KB (382 words) - 12:33, 16 January 2024
  • the association of L1CAM with neuropilin-1. Neuropilin-1 interacts with Plexin-A proteins to form the Semaphorin-3A receptor complex. Semaphorin-a3A is...
    36 KB (3,347 words) - 19:00, 17 April 2024
  • Thumbnail for Hailan Hu
    explored the role of the plexin receptor and the Rho family GTPases in central nervous system development in Drosophila. Plexins are receptors involved...
    21 KB (2,326 words) - 15:53, 3 June 2024
  • Thumbnail for Retinal ganglion cell
    RGCs and the midline glia and acts along with Sema6D, mediated via the plexin-A1 receptor. VEGF-A is released from the midline directs RGCs to take a...
    29 KB (3,521 words) - 03:39, 17 June 2024
  • Thumbnail for Semaphorin 3E
    proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based...
    4 KB (618 words) - 07:59, 3 December 2023
  • Thumbnail for VEGF receptor
    Blondelle J, Singh MK, Flaherty KM, Means PC, et al. (August 2011). "Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1"...
    8 KB (755 words) - 18:51, 2 November 2023
  • Thumbnail for Sema domain
    also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805) and in viral proteins. CD100 (also called SEMA4D) is...
    4 KB (520 words) - 19:02, 6 July 2021
  • Thumbnail for PLXNB2
    Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene. Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that...
    6 KB (739 words) - 11:43, 4 March 2023
  • Thumbnail for Chromosome 10
    PLEKHS1 encoding protein Pleckstrin homology domain containing S1 PLXDC2: plexin domain-containing protein 2 PRAP1: encoding protein Proline rich acidic...
    28 KB (1,967 words) - 02:02, 11 April 2024
  • neuropilin 1 and plexin A1. While some of the other class of semaphorins directly bind to plexin receptors, Sema3A does not bind to plexin directly. Instead...
    21 KB (2,518 words) - 22:06, 10 December 2023
  • Thumbnail for PLXDC1
    Plexin domain-containing protein 1 is a protein that in humans is encoded by the PLXDC1 gene. GRCh38: Ensembl release 89: ENSG00000161381 – Ensembl, May...
    3 KB (421 words) - 21:04, 13 October 2022
  • Thumbnail for Tropic cues involved in growth cone guidance
    H (Mar 2003). "Identification and characterization of a novel mouse plexin, plexin-A4". Mechanisms of Development. 120 (3): 385–96. doi:10.1016/S0925-4773(02)00421-5...
    26 KB (3,128 words) - 08:14, 18 August 2023