pressure. Renin inhibitor is often preceded by direct, called direct renin inhibitor in order to distinguish its mechanism from other renin–angiotensin–aldosterone...

losartan, irbesartan or candesartan) rather than a direct oral renin inhibitor. ACE inhibitors or ARBs are also part of the standard treatment after a heart...

The renin-angiotensin system (RAS), or renin-angiotensin-aldosterone system (RAAS), is a hormone system that regulates blood pressure, fluid, and electrolyte...

demand from the heart. ACE inhibitors inhibit the activity of angiotensin-converting enzyme, an important component of the renin–angiotensin system which...

effectively reduce hypertension. Aliskiren (developed by Novartis) is a renin inhibitor which has been approved by the U.S. FDA for the treatment of hypertension...

ACE inhibitor or ARB. Such patients should consider alternative antihypertensive treatment as necessary. Aliskiren is an inhibitor of renin. Renin, the...

causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates...

SPH3127 is a small-molecule renin inhibitor developed by Shanghai Pharmaceuticals for hypertension and kidney disease. It is believed to be more potent...

valsartan includes a warning stating the drug should not be used with the renin inhibitor aliskiren in people with diabetes. It also states the safety of the...

ATC code C09 Agents acting on the renin–angiotensin system is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system...

pressure. Aliskiren is a renin inhibitor, which works to reduce primary hypertension (that with no known cause) by binding to renin and preventing it from...

Remikiren is a renin inhibitor under development for the treatment of hypertension (high blood pressure). It was first developed by Hoffmann–La Roche...

combinations with angiotensin II receptor blockers (ARBs) or direct renin inhibitors and is contraindicated in people with a history of angioedema and pregnancy...

Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein that in humans is encoded...

pregnancy and breastfeeding is not recommended. It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity. Ramipril was patented...

treatment of hypertension (high blood pressure). It contains aliskiren, a renin inhibitor, and hydrochlorothiazide, a diuretic. It is taken by mouth. The most...

studies on larger populations are needed. As with other drugs that inhibit the renin–angiotensin system, if candesartan is taken by pregnant women during...

cyclooxygenase inhibitor Proton-pump inhibitor Renin inhibitor Selective glucocorticoid receptor modulator Serotonergic Statin – HMG-CoA reductase inhibitor This...

hepatic dysfunction. Azilsartan must not be used with aliskiren, a renin inhibitor, in patients with diabetes as this increases the risk of serious adverse...

pharmacophore of SGLT inhibitors. Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via...

the renin–angiotensin system. As a result of losartan dosing, plasma renin activity increases due to the removal of the angiotensin II feedback. Renin is...

bind to and inhibit the angiotensin II receptor type 1 (AT1) and thereby block the arteriolar contraction and sodium retention effects of renin–angiotensin...

patients at risk of substance abuse. Norepinephrine reuptake inhibitor Monoamine reuptake inhibitor Ding, Y.-S.; Naganawa, M.; Gallezot, J.-D.; Nabulsi, N.;...

duration of pregnancy as it may harm the baby. Lisinopril works by inhibiting the renin–angiotensin–aldosterone system. Lisinopril was patented in 1978 and...

Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the...

Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease,...

Perkovic V, Li X, Ninomiya T, Hou W, et al. (May 2016). "Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients With CKD:...

protease inhibitor Renin inhibitors Aliskiren Ciprokiren Ditekiren Enalkiren Pepstatin Remikiren Terlakiren Zankiren Exopeptidase inhibitor Enkephalinase...

RfHTN does not respond to diuretics; calcium channel blockers; ACE, or renin inhibitors; endothelium receptor blockers; Angiotensin II, Adrenergic, Aldosterone...

Telmisartan is contraindicated during pregnancy. Like other drugs affecting the renin–angiotensin system (RAS), telmisartan can cause birth defects, stillbirths...