Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye. It is the...

The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional...

Trilateral retinoblastoma (TRb) is a malignant midline primitive neuroectodermal tumor occurring in patients with inherited uni- or bilateral retinoblastoma. In...

the retinoblastoma tumor suppressor protein. Alfred Knudson, a pediatrician and cancer geneticist, proposed that in order to develop retinoblastoma, two...

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been shown to interact with:...

cancer. During this transition, G1 cyclin D-Cdk4/6 dimer phosphorylates retinoblastoma releasing transcription factor E2F, which then drives the transition...

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. The protein encoded by this gene is similar...

cases of retinoblastoma, a tumor of the retina that occurs both as an inherited disease and sporadically. He noted that inherited retinoblastoma occurs...

Flexner–Wintersteiner rosettes, a spoke-and-wheel shaped cell formation seen in retinoblastoma and certain other ophthalmic tumors,) have been described as a form...

often called blasts. Examples are nephroblastoma, medulloblastoma, and retinoblastoma. The suffix -blastoma is used to imply a tumor of primitive, incompletely...

lentis (PFV/PHPV), retinoblastoma, and retrolental fibroplasia. Because of the potentially life-threatening nature of retinoblastoma, a cancer, that condition...

concrete structures Retinoblastoma, a childhood cancer of the eyes caused by a mutation in the retinoblastoma protein Retinoblastoma protein, a tumor suppressor...

cancer types where a copy of TP53 gene gets inactivated, 13q14 loss in retinoblastoma with RB1 gene deletion or 11p13 in Wilms' tumor where WT1 gene is lost...

complex. Cyclin D-CDK4/6 complexes in turn mono-phosphorylates the retinoblastoma susceptibility protein (Rb) to pRb. The un-phosphorylated Rb tumour...

Gallie CM OOnt is a Canadian ophthalmologist. She is the Head of the Retinoblastoma Program in the Hospital for Sick Children (Toronto) Department of Ophthalmology...

be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma. The most common eyelid tumor is called basal cell carcinoma. This tumor...

consists of three proteins: RB – Retinoblastoma protein p107 – Retinoblastoma-like protein 1 p130 – Retinoblastoma-like protein 2 They play crucial roles...

former political party in Brunei Retinoblastoma protein, pRb, an important tumour-suppressor gene in retinoblastoma Progesterone receptor B Paso Robles...

or bilateral retinoblastoma. When retinoblastoma patients present with pineoblastoma this is characterized as "trilateral retinoblastoma". Up to 5% of...

California. He has Rusyn ancestry. At the age of two he lost his left eye to retinoblastoma and has had a prosthetic eye ever since. As a teenager, he attended...

some of the pathology the red reflex is used to detect. For example, retinoblastoma, a neuroblastic tumor that can cause a dampened or even white reflex...

at cyclin E's C-terminal region and interacts with proteins of the retinoblastoma family including Rb1, p107, and p130. Cyclin E is predominantly found...

risk of various cancers also increase the risk of lung cancer, namely retinoblastoma and Li–Fraumeni syndrome. As with all cancers, lung cancer is triggered...

may play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells...

firefighter. When he was almost one year old, Healey lost his sight due to retinoblastoma, a rare cancer of the eyes. His eyes had to be surgically removed, and...

up in Wythenshawe, Manchester. Like her brother Patrick, Aherne had retinoblastoma in childhood, which left her partially sighted in one eye. She attended...

tumors Ganglioneuroma, Neuroblastoma, Atypical teratoid rhabdoid tumor, Retinoblastoma, Esthesioneuroblastoma Nerve sheath tumors Neurofibroma (Neurofibrosarcoma...

conditions can transform cells using their early gene products. E1A (binds Retinoblastoma tumor suppressor protein) has been found to immortalize primary cells...

cyclin-cdk complexes. These cyclin-cdk complexes phosphorylate the Retinoblastoma (Rb) protein, a tumor suppressor bound with the E2F family of transcription...

also in investigations of cell cycle control mechanisms such as the retinoblastoma protein. The World Health Organization's International Agency for Research...