as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has...

anophthalmia is mutated SOX2 gene. Sox2 anophthalmia syndrome is caused by a mutation in the Sox2 gene that does not allow it to produce the Sox2 protein that regulates...

pluripotent cells. Virally induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create pluripotent (iPS)...

in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription...

SIX3 SIX6 SMOC1 SNX3 SOX2 SRD5A3 STRA6 TBC1D20 TBC1D32 TBX22 TCOF1 TENM3 TFAP2A TMEM98 TMEM67 TMX3 VAX1 VSX2 YAP1 ZEB2 ZIC2 SOX2 has been implicated in...

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies...

promote differentiation, but are also controlled by levels of Sox2. A decrease in Sox2 accompanies increased levels of Oct-4 to promote a mesendodermal...

overexpressing in the primed pluripotent stem cell a reprogramming factor Klf4, or Sox2 and Klf4 (SK cocktail). Klf4 alone can reset mouse primed cells, but SK is...

group) DNA-binding domain and functions primarily in neurogenesis. SOX1, SOX2 and SOX3, members of the SOX gene family (specifically the SOXB1 group),...

affected. In addition to HESX1, mutations in OTX2, SOX2 and PAX6 have been implicated in SOD. SOX2 mutations in SOD patients are associated with severe...

pioneered in 2006 using mouse fibroblasts and four transcription factors, Oct4, Sox2, Klf4 and c-Myc; this technique, called reprogramming, later earned Shinya...

treatment upon reflux of a large excess of thionyl chloride or thionyl bromide (SOX2) in the presence of a small amount of a nitrogen base, such as a tertiary...

Sanketi, Bhargav; Kurpios, Natasza; McCune, Amy (2020). "Changing in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary...

Sinclair's group published that three Yamanaka transcription factors, Oct4, Sox2, and Klf4, when delivered together in a virus, could safely reverse the age...

pluripotent stem cells are generated by the transcription factors Myc, Oct3/4, Sox2, and Klf4. Sophie M. Worobec (2008). "Treatment of leprosy/Hansen's disease...

Halibut is located on chromosome 9 and it is likely to be bmpr1ba. The gene sox2 is likely to play the same role in the Greenland Halibut. The North Pacific...

factors and cell surface proteins. The transcription factors Oct-4, Nanog, and Sox2 form the core regulatory network that ensures the suppression of genes that...

with Sox2 for the expression of FGF4 which could aid in differentiation. Sox2 is a gene used in maintaining pluripotency in stem cells. Oct4 and Sox2 work...

preventing differentiation. Cooperative regulation of Rex1 is seen with Sox2 and Nanog. Oct3/4 can both repress and activate the Rex1 promoter. In cells...

factors: Sox2 and Oct4 proteins. These transcription factors cause the pluripotent mouse embryonic stem cells to select a germ layer fate. Sox2 promotes...

Human neural stem cells stained for Sox2, in green, and vimentin, in red. Vimentin is a type III intermediate filament (IF) protein....

anti-inflammatory, possibly mediated via PPAR delta activation Nuciferine suppresses the SOX2-AKT/STAT3 signaling pathway in animal models. Targeting SOX-2 pathways in...

do not turn on the Cdx2 gene, and express high levels of Oct4, Nanog, and Sox2. These genes suppress Cdx2 and the inside cells maintain pluripotency generate...

C.; Sanketi, B. D.; Kurpios, N.; McCune, A. (2020). "Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary...

The VZ and SVZ are indicated by immunohistochemical labelling of Sox2 and Tbr2 gene expression in the embryonic mouse forebrain at embryonic day 13.5....

early embryo, but could in the end reduce it to four transcription factors – Sox2, Oct4, Klf4 and c-Myc. The 2012 Nobel Prize in Physiology or Medicine was...

are also important in processes such as neuronal development. For example, Sox2 and Sox3 are involved in the transition of epithelial granule cells in the...

fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4) Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4) Transdifferentiation...

hox genes, the morphogen sonic hedgehog, and transcription factors such as sox2 and sox9. Recent research has suggested that most foregut malformations are...

expressed or induced in bird feet, such as the scale-feather converters Sox2, Zic1, Grem1, Spry2, and Sox18. Feathers and scales are made up of two distinct...