Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine...

important phospholipid. Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2. This leads to...

coordinated for this purpose. Sphingosine kinase (SK) is a lipid kinase that catalyzes the conversion of sphingosine to sphingosine-1-phosphate (S1P). Sphingolipids...

plasma membrane, will convert ceramide to sphingosine. Sphingosine is then phosphorylated by sphingosine kinase (SK) isoenzymes. There are two identified...

the formation of sphingosine, Moreover, a phosphate group can be attached to ceramide (phosphorylation) by the enzyme, ceramide kinase. It is also possible...

Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene. This gene encodes one of two sphingosine kinase isozymes that catalyze the...

Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate...

structural analogue of sphingosine and is phosphorylated by sphingosine kinases in the cell (most importantly sphingosine kinase 2). The molecular biology...

and becomes active when being phosphorylated by kinases. Then the phosphorylated drug binds to sphingosine receptors: not only S1P1, but also S1P3, S1P4...

recruitment of phagocytes to apoptotic cells is not yet known. Sphingosine kinase 1 and sphingosine kinase 2 have been linked to S1P generation during apoptosis...

sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after...

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate...

Ceramides are a family of waxy lipid molecules. A ceramide is composed of sphingosine and a fatty acid joined by an amide bond. Ceramides are found in high...

that is used for the treatment of ulcerative colitis. It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the...

lipid, recruiting cytosolic proteins to appropriate membranes (e.g., sphingosine kinase 1). PA plays very important role in phototransduction in Drosophila...

acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P). Ceramide...

muscle contraction. When transmural pressure increases, sphingosine kinase 1 phosphorylates sphingosine to S1P, which binds to the S1P2 receptor in plasma...

Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis...

Opaganib (ABC294640) is a drug which acts as an inhibitor of the enzyme sphingosine kinase 2. It is under development as a potential treatment agent for several...

inducing PAR-1 dependent sphingosine kinase-1 activation and up-regulating sphingosine-1-phosphate with sphingosine kinase.: 3165  Several studies have...

have dinner with a group of her scientist friends who speculate that sphingosine kinase could lead to a cure for cancer. As a result, the President demands...

Alternatively, palmitoyl-CoA is used as a substrate in the biosynthesis of sphingosine (this biosynthetic pathway does not require transfer into the mitochondria)...

N,N-Dimethylsphingosine (also known as DMS) is an inhibitor of sphingosine kinase. In rats with neuropathic pain, the natural metabolite DMS is unregulated...

of relapsing multiple sclerosis and ulcerative colitis. It acts as a sphingosine-1-phosphate receptor (S1PR) agonist, sequestering lymphocytes to peripheral...

EA, Gomez S, Jaspers I, Allbritton NL (April 2015). "Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood". Integrative...

the synthesis of phosphatidic acids. Autotaxin GPR35 Phosphatidic acid Sphingosine-1-phosphate Gintonin van Corven, Emile J.; Groenink, Alida; Jalink, Kees;...

SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...

SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...

shown to involve activation of the enzyme sphingosine kinase, and generation of the bioactive lipid, sphingosine-1-phosphate, which promotes growth by transactivating...

"Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression". Hepatology. 61 (4): 1216–26. doi:10...