• Thumbnail for 5-Methylcytosine
    5-Methylcytosine is a methylated form of the DNA base cytosine (C) that regulates gene transcription and takes several other biological roles. When cytosine...
    23 KB (2,630 words) - 08:55, 2 September 2024
  • Methylcytosine may refer to: 5-Methylcytosine 1-Methylcytosine, a nucleic acid in Hachimoji DNA N(4)-Methylcytosine 6-Methylcytosine Cytosine Nucleic acid...
    538 bytes (57 words) - 03:49, 1 March 2021
  • vitro through the use of bisulfite, which deaminates cytosine, but not 5-methylcytosine. This property has allowed researchers to sequence methylated DNA to...
    6 KB (708 words) - 13:07, 2 October 2024
  • Thumbnail for DNA methylation
    and cytosine. The modified bases are N6-methyladenine, 5-methylcytosine and N4-methylcytosine. Cytosine methylation is widespread in both eukaryotes and...
    116 KB (13,328 words) - 02:09, 23 October 2024
  • Thumbnail for 5-Methylcytidine
    5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It is found in ribonucleic acids of animal, plant, and bacterial origin. Dunn...
    2 KB (53 words) - 16:08, 27 April 2023
  • Thumbnail for Cytosine
    also be methylated into 5-methylcytosine by an enzyme called DNA methyltransferase or be methylated and hydroxylated to make 5-hydroxymethylcytosine. The...
    10 KB (906 words) - 20:09, 27 October 2024
  • Thumbnail for Tet methylcytosine dioxygenase 2
    modified DNA base methylcytosine to 5-hydroxymethylcytosine. The first mechanistic reports showed tissue-specific accumulation of 5-hydroxymethylcytosine...
    25 KB (2,654 words) - 11:00, 12 October 2024
  • Thumbnail for 5-Hydroxymethylcytosine
    be generated by oxidation of 5-methylcytosine, a reaction mediated by TET enzymes. Every mammalian cell seems to contain 5-Hydroxymethylcytosine, but the...
    16 KB (1,727 words) - 23:08, 30 October 2024
  • reamination, or the conversion of 5-methylcytosine back into cytosine, has not been observed in RNA. 5-methylcytosine modifications are typically found...
    61 KB (7,732 words) - 20:34, 13 May 2024
  • Thumbnail for CpG site
    islands. Cytosines in CpG dinucleotides can be methylated to form 5-methylcytosines. Enzymes that add a methyl group are called DNA methyltransferases...
    51 KB (5,481 words) - 20:28, 15 August 2024
  • Thumbnail for Epigenetics
    groups to the DNA, mostly at CpG sites, to convert cytosine to 5-methylcytosine. 5-Methylcytosine performs much like a regular cytosine, pairing with a guanine...
    160 KB (18,271 words) - 15:20, 28 October 2024
  • Methylation (redirect from 5-O-Methylation)
    present in eukaryotes. 5-methylcytosine (5-mC) also commonly occurs in various RNA molecules. Recent data strongly suggest that m6A and 5-mC RNA methylation...
    28 KB (3,051 words) - 10:03, 4 June 2024
  • Thumbnail for DNA
    Modified Cytosine N4-Methylcytosine 5-Carboxylcytosine 5-Formylcytosine 5-Glycosylhydroxymethylcytosine 5-Hydroxycytosine 5-Methylcytosine Modified Thymidine...
    166 KB (17,843 words) - 13:16, 19 September 2024
  • Thumbnail for TET enzymes
    ten-eleven translocation (TET) methylcytosine dioxygenases. They are instrumental in DNA demethylation. 5-Methylcytosine (see first Figure) is a methylated...
    32 KB (3,984 words) - 04:59, 28 October 2024
  • Thumbnail for Bisulfite
    into uracil, but does not affect 5-methylcytosine, a methylated form of cytosine with a methyl group attached to carbon 5. When the bisulfite-treated DNA...
    10 KB (1,061 words) - 08:25, 30 March 2024
  • Specifically, modified saRNA with 5-methylcytosine and 5-hydroxymethylcytidine had reduced expression of IFNα1 8.5-fold and IFNβ1 3-fold respectively...
    13 KB (1,425 words) - 07:08, 29 October 2024
  • Thumbnail for Bisulfite sequencing
    DNA with bisulfite converts cytosine residues to uracil, but leaves 5-methylcytosine residues unaffected. Therefore, DNA that has been treated with bisulfite...
    34 KB (4,086 words) - 04:30, 2 November 2024
  • Thumbnail for 5-Methyluridine
    fit, phenotype. 5-Methylcytosine 3-Methyluridine The term ribothymidine is especially used to describe its unusual occurrence in RNA. "5-Methyluridine"...
    4 KB (250 words) - 18:21, 28 April 2024
  • Thumbnail for Nucleotide base
    acid chain has been formed. In DNA, the most common modified base is 5-methylcytosine (m5C). In RNA, there are many modified bases, including those contained...
    15 KB (1,439 words) - 05:43, 29 October 2024
  • Thumbnail for Tet methylcytosine dioxygenase 1
    of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). TET1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate...
    17 KB (1,893 words) - 03:46, 22 January 2024
  • Thumbnail for Transition (genetics)
    substitutions than transversions, as one observes in the codon table. 5-Methylcytosine is more prone to transition than unmethylated cytosine, due to spontaneous...
    3 KB (245 words) - 01:39, 4 August 2024
  • Thumbnail for Whole genome bisulfite sequencing
    cytosine reacted much faster to sodium bisulfite treatment than did 5-methylcytosine. This difference in reaction rates created the possibility of identifying...
    22 KB (2,517 words) - 05:07, 4 July 2024
  • Thumbnail for Germline
    DNA cytosine to form 5-methylcytosine. This usually occurs in the DNA sequence CpG, changing the DNA at the CpG site from CpG to 5-mCpG. Methylation of...
    17 KB (2,079 words) - 22:24, 28 September 2024
  • isolating methylated DNA fragments via an antibody raised against 5-methylcytosine (5mC). This technique was first described by Weber M. et al. in 2005...
    23 KB (2,851 words) - 03:32, 18 December 2023
  • modifications include DNA cytosine methylation to form 5-methylcytosine and 5-methylcytosine demethylation. These modifications are critical for cell...
    25 KB (2,758 words) - 10:48, 22 October 2024
  • A. thaliana, N. tabacum and other plants by active demethylation. 5-methylcytosine residues are excised and replaced with unmethylated cytosines allowing...
    34 KB (4,056 words) - 12:54, 29 October 2024
  • Thumbnail for 1-Methylcytosine
    1-Methylcytosine is a methylated form of the DNA base cytosine. In 1-methylcytosine, a methyl group is attached to the 1st atom in the 6-atom ring. This...
    2 KB (128 words) - 10:42, 11 January 2024
  • Thumbnail for Transcription (biology)
    (where 5' cytosine is followed by 3' guanine or CpG sites). 5-methylcytosine (5-mC) is a methylated form of the DNA base cytosine (see Figure). 5-mC is...
    58 KB (6,788 words) - 18:55, 25 October 2024
  • Thumbnail for 5-Formylcytosine
    formula is C5H5N3O2. Similarly to the related cytosine modifications 5-Methylcytosine (5mC) and 5hmC, 5fC is broadly distributed across the mammalian genome...
    9 KB (917 words) - 13:13, 24 May 2023
  • Thumbnail for Base excision repair
    deamination of guanine. (Thymidine products following deamination of 5-methylcytosine are more difficult to recognize, but can be repaired by mismatch-specific...
    29 KB (3,493 words) - 23:41, 26 October 2024