• Thumbnail for ADME
    ADME is the four-letter abbreviation (acronym) for absorption, distribution, metabolism, and excretion, and is mainly used in fields such as pharmacokinetics...
    7 KB (817 words) - 21:13, 17 May 2024
  • Thumbnail for Pharmacokinetics
    enters into contact with the organism, these are described using the acronym ADME (or LADME if liberation is included as a separate step from absorption):...
    46 KB (4,510 words) - 13:42, 23 September 2024
  • distribute to tissues, metabolize, or excrete (this combination is termed ADME) a drug are predisposed to develop SJS.[citation needed] Although SJS can...
    56 KB (5,871 words) - 00:47, 10 November 2024
  • fulfillment of the ADME criteria. To be an effective drug, a compound not only must be active against a target, but also possess the appropriate ADME (Absorption...
    5 KB (604 words) - 02:36, 28 June 2024
  • Thumbnail for Pharmacology
    pharmacokinetics discusses the absorption, distribution, metabolism, and excretion (ADME) of chemicals from the biological systems. Pharmacology is not synonymous...
    48 KB (4,744 words) - 21:42, 24 September 2024
  • Thumbnail for Tetramethylammonium
    Tetramethylammonium (TMA) is the simplest quaternary ammonium cation. It has the chemical formula [Me4N]+ and consists of four methyl groups (−CH3, denoted...
    17 KB (1,706 words) - 19:26, 15 September 2024
  • Thumbnail for ChEMBL
    saw the introduction of the new resource ADME SARfari - a tool for predicting and comparing cross-species ADME targets. ChEMBL: Quick Tour on EBI Train...
    9 KB (853 words) - 10:20, 18 August 2023
  • improve how the drug is absorbed, distributed, metabolized, and excreted (ADME). Prodrugs are often designed to improve bioavailability when a drug itself...
    12 KB (1,281 words) - 06:14, 9 September 2024
  • involved in the development of specific drug-induced SCARs. Variations in ADME, i.e. an individual's efficiency in absorbing, distributing, metabolizing...
    38 KB (4,291 words) - 18:22, 3 September 2024
  • Thumbnail for International Phonetic Alphabet
    voiced environments (e.g. hazte /ˈaΘte/ → [ˈaθte], vs hazme /ˈaΘme/ → [ˈaðme], or las manos /laS ˈmanoS/ → [lazˈmanos]). ⟨V⟩, ⟨F⟩ and ⟨C⟩ have completely...
    166 KB (16,106 words) - 00:23, 16 November 2024
  • Cypriot city of Limassol in 2016. It grew out of the duo's Kazan-based company AdMe, which focused on digital advertising and content distribution. Later that...
    20 KB (1,721 words) - 15:01, 23 March 2024
  • silico prediction of drug absorption, distribution, metabolism excretion (ADME) and potential drug-drug interactions. Simcyp’s R&D activities focus on the...
    7 KB (600 words) - 19:21, 22 September 2024
  • by We Are Dark Angels Production companies Jaguar Bite BurningBull SPFX ADME Studios Buffalo 8 Productions Splendid Film BondIt Media Capital Dark Mark...
    4 KB (317 words) - 20:15, 10 October 2024
  • Thumbnail for T-2 mycotoxin
    T-2 mycotoxin is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and other animals...
    27 KB (3,186 words) - 00:49, 26 October 2024
  • individuals express in their antigen presentation immune pathways; their ADME, i.e. efficiency in Absorbing, Distributing to tissues, Metabolizing, and/or...
    35 KB (4,080 words) - 05:51, 8 September 2024
  • Thumbnail for 7-Hydroxymitragynine
    "Evaluation of in Vitro Absorption, Distribution, Metabolism, and Excretion (ADME) Properties of Mitragynine, 7-Hydroxymitragynine, and Mitraphylline". Planta...
    9 KB (748 words) - 02:42, 15 November 2024
  • Thumbnail for Antalarmin
    Antalarmin (CP-156,181) is a drug that acts as a CRH1 antagonist. Corticotropin-releasing hormone (CRH), also known as Corticotropin-releasing factor,...
    29 KB (3,191 words) - 06:49, 5 January 2024
  • Thumbnail for Chemotherapy
    2015). "Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp". Cancer Cell International. 15 (1): 71. doi:10.1186/s12935-015-0221-1...
    155 KB (17,518 words) - 23:36, 26 October 2024
  • a team with backgrounds in social media content creation, who launched AdMe. In March 2017, the company founded the YouTube channel, Bright Side. On...
    17 KB (1,347 words) - 10:25, 8 November 2024
  • Thumbnail for HepaRG
    the stability of the line. HepaRG cells have many applications in in-vitro ADME (absorption, distribution, metabolism, and excretion) studies. They were...
    25 KB (2,666 words) - 15:23, 29 June 2024
  • Thumbnail for First pass effect
    metabolism enzymes is given concurrently (e.g., propranolol and chlorpromazine). ADME, an acronym in pharmacokinetics and pharmacology standing for absorption...
    7 KB (858 words) - 17:05, 6 July 2024
  • pharmacodynamics and safety profile of a drug. Formulations Pharmaceutical formulation ADME Pharmacology Medicinal chemistry Pesticide formulation v t e...
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  • Thumbnail for Preclinical development
    the body) (PD), pharmacokinetics (what the body does to the drug) (PK), ADME, and toxicology testing. This data allows researchers to allometrically estimate...
    7 KB (804 words) - 14:26, 27 January 2024
  • Thumbnail for Lipinski's rule of five
    body, including their absorption, distribution, metabolism, and excretion ("ADME"). However, the rule does not predict if a compound is pharmacologically...
    10 KB (1,196 words) - 04:10, 26 September 2024
  • Thumbnail for Memantine
    memantine is marketed under many brand names worldwide including Abixa, Adaxor, Admed, Akatinol, Alceba, Alios, Almenta, Alois, Alzant, Alzer, Alzia, Alzinex...
    67 KB (6,296 words) - 21:21, 18 October 2024
  • LADME (L)ADME: (Liberation) Absorption Distribution Metabolism Excretion (Clearance)...
    11 KB (1,271 words) - 08:43, 18 August 2023
  • Thumbnail for Proof of concept
    investigate how the new drug is absorbed, distributed, metabolised and excreted (ADME studies). Phase IIA is typically conducted in up to 100 patients with the...
    16 KB (2,161 words) - 08:35, 16 June 2024
  • underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption, distribution, metabolism, and excretion) characteristics. Officially...
    22 KB (2,828 words) - 19:32, 20 December 2023
  • genotypes in cervical cancer. On October 4, 2011 Sequenom introduced iPLEX ADME PGx Panel on MassARRAY System, developed to genotype polymorphisms in genes...
    22 KB (1,978 words) - 02:12, 1 September 2024
  • Thumbnail for Benzo(c)fluorene
    Benzo[c]fluorene is a polycyclic aromatic hydrocarbon (PAH) with mutagenic activity. It is a component of coal tar, cigarette smoke and smog and thought...
    20 KB (2,141 words) - 06:27, 15 January 2024