Cohesin is a protein complex that mediates sister chromatid cohesion, homologous recombination, and DNA looping. Cohesin is formed of SMC3, SMC1, SCC1...

molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction...

control. The cohesin complex is responsible for keeping together sister chromatids and provides binding sites for spindle attachment. Cohesin is loaded onto...

across species and are highly enriched with CCCTC-binding factor (CTCF) and cohesin. In addition, some types of genes (such as transfer RNA genes and housekeeping...

proteins that function in the cohesin pathway. SMC1A, SMC3 and RAD21 proteins are structural components of the cohesin ring complex. NIPBL is involved...

the cohesin complex suggests that this complex connects directly both sister chromatids. In this proposed structure, the SMC components of cohesin play...

humans.  RAD21 protein is a structural component of the highly conserved cohesin complex consisting of RAD21, SMC1A, SMC3, and SCC3 [ STAG1 (SA1) and STAG2...

down the center. Unlike in mitosis, only the cohesin from the chromosome arms is degraded while the cohesin surrounding the centromere remains protected...

The destruction of securin unleashes separase which then breaks down cohesin, a protein responsible for holding sister chromatids together. At this...

Scc2 and Scc4. Cohesin interacts with the chromatin at specific loci. High levels of cohesin binding are observed at the centromere. Cohesin is also loaded...

bipolar tension. Sister chromatids require active separase to hydrolyze the cohesin that bind them together prior to progression to anaphase. Any unattached...

complex with Cohesin. There are three types of Dockerin domains: I, II and III which bind to Cohesin Type I, Cohesin Type II and Cohesin Type III respectively...

is assembled and joins the homologous chromosomes along their lengths. Cohesin crosslinking occurs between the homologous chromosomes and helps them resist...

key regulator of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1...

in chromatin form) are linked along their length by the action of the cohesin complex. It is now believed that this complex is mostly released from chromosome...

functions: A pair of SMC1 and SMC3 constitutes the core subunits of the cohesin complexes involved in sister chromatid cohesion. SMC1 and SMC3 also have...

protect centromeric cohesin, not only for bringing PP2A to cohesin, but also physically shield out the negative regulator WAPAL from cohesin. GRCh38: Ensembl...

cellulases and xylanase subunits into the cohesive complex, by combining its cohesin domains with a typical dockerin domain present on each of the subunit enzymes...

a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during...

gene. NIPBL is required for the association of cohesin with DNA and is the major subunit of the cohesin loading complex. Heterozygous mutations in NIPBL...

the nuclear lamina. CTCF is also involved in V(D)J recombination. Cohesin: The cohesin complex was initially discovered as a key player in mitosis, binding...

whereby the cohesin ring is actively being translocated along the DNA until it meets CTCF. CTCF has to be in a proper orientation to stop cohesin. CTCF binding...

Cohesin subunit SA-1 (SA1) is a protein that in humans is encoded by the STAG1 gene. SA1 is a subunit of the Cohesin complex which mediates sister chromatid...

causes high copy number. Aneuploidy Chromomere Chromosome segregation Cohesin Condensin DNA Genetic deletion Epigenetics For information about chromosomes...

cohesion which we now know encode subunits of the cohesin complex. Nasmyth has since shown that cohesin forms a ring, that sister chromatids are held together...

subunit of the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of...

two DNA loci bound by the transcription factor CTCF and co-occupied by cohesin. Insulated neighborhoods are thought to be structural and functional units...

Chromosomal regulation Cohesin subunit SA2/Scc3 Cohesin regulator Wapl Cohesin regulator Pds5 Cohesin loading factor Scc2 Cohesin protease Separase Condensin...

chromosomes, sister kinetochore monoorientation, protection of centromeric cohesin and spindle-pole body cohesion and duplication. The kinetochore is composed...

duplication results in two identical sister chromatids bound together by cohesin proteins at the centromere. When mitosis begins, the chromosomes condense...