CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed...
11 KB (1,393 words) - 18:39, 23 February 2024
ASO probes CpG Oligodeoxynucleotide, an ODN with immunostimulatory properties Polypurine reverse-Hoogsteen hairpins, PPRHs, oligonucleotides that can bind...
23 KB (2,581 words) - 08:14, 10 June 2024
pore glass (CPG, see "Solid support material" below), which initiated a massive research effort in solid-phase synthesis of oligonucleotides and eventually...
79 KB (9,462 words) - 18:31, 28 January 2024
Methylation specific oligonucleotide microarray, also known as MSO microarray, was developed as a technique to map epigenetic methylation changes in DNA...
7 KB (690 words) - 04:48, 3 May 2024
An allele-specific oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe...
10 KB (1,292 words) - 20:49, 18 September 2023
DNA methylation (section CpG islands)
only exception for this global CpG depletion resides in a specific category of GC- and CpG-rich sequences termed CpG islands that are generally unmethylated...
114 KB (13,179 words) - 02:59, 22 July 2024
Arthur M.; Endres, Stefan; Hartmann, Gunther (2001). "Distinct CpG oligonucleotide sequences activate human γ δ T cells via interferon-α/-β". European...
15 KB (1,536 words) - 01:55, 30 June 2024
receptor 9 (TLR9) using CpG motif DNA. Later on, he adopted the strategy as a platform for delivery of various oligonucleotide drugs to target oncogenic...
14 KB (1,070 words) - 15:11, 4 January 2024
injected directly into a tumor in combination with an unmethylated CpG oligonucleotide, which as a TLR9 ligand activates expression of OX40 so that it can...
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analysis of methylation. Oligonucleotide microarrays are designed using pairs of oligonucleotide hybridization probes targeting CpG sites of interest. One...
34 KB (4,084 words) - 21:59, 8 January 2024
profiles. It can be applied to large datasets generated using either oligonucleotide arrays (MeDIP-chip) or next-generation sequencing (MeDIP-seq), providing...
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target regions of the human genome to measure methylation levels at 27,578 CpG dinucleotides in 14,495 genes. In 2008, Illumina released the Infinium HumanMethylation450...
11 KB (1,179 words) - 12:28, 8 August 2024
group of genes or gene clusters, a non-coding region, or a synthetic oligonucleotide such as a primer. Qualitatively, guanine (G) and cytosine (C) undergo...
18 KB (2,201 words) - 20:06, 26 January 2024
modification primarily occurs at CpG sites, which in turn tend to cluster in regions called CpG islands. There is a small fraction of CpG islands that can overlap...
23 KB (2,851 words) - 03:32, 18 December 2023
tendency of methylated cytosines to cluster at CpG islands (CGIs) to enrich for areas of the genome with a high CpG content. This reduces the cost of sequencing...
74 KB (8,560 words) - 14:53, 17 August 2024
guanine, a CpG site. The number of CpG sites in the human genome is about 28 million. Depending on the type of cell, about 70% of the CpG sites have a...
102 KB (11,438 words) - 16:50, 17 July 2024
which involve the administration of artificial DNA oligonucleotides containing the CpG motif. CpG DNA has applications in treating allergies such as asthma...
20 KB (2,551 words) - 21:43, 4 April 2024
(KAT) uses a modified version of Jellyfish to analyze k-mer counts Oligonucleotide Genomic signature Some of the content in this article was copied from...
50 KB (6,078 words) - 19:16, 11 July 2024
use. To improve the delivery issues, chemical modifications, and new oligonucleotide designs have been studied to enhance the drug distribution, side effects...
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ranging from bacteria to mammals. They are preferentially localized at CpG island promoters in human cells and highly transcribed regions in yeast....
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hypermethylation in cancer cells. It is well known that hypermethylation of CpG-islands in regulatory regions of promoter and/or first exon in a variety...
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Cosmids Cot value Cotransduction Cotransformation Coupling Covariance cpDNA CpG island Craniosynostosis Cri du chat cRNA Cross Cross-fertilization Crossbreed...
33 KB (2,517 words) - 18:25, 11 December 2023
Andrieu C, Guy C, Copigny F, et al. (September 2007). "High-resolution oligonucleotide array-CGH applied to the detection and characterization of large rearrangements...
121 KB (13,581 words) - 14:59, 8 August 2024
Controlled pore glass (CPG) with pore sizes between 50 and 300 nm is also excellently suited for the synthesis of oligonucleotides. In this application...
11 KB (1,521 words) - 18:25, 8 August 2024
(BNA), morpholino, and peptide nucleic acid (PNA). Although these oligonucleotides have a different backbone sugar—or, in the case of PNA, an amino acid...
49 KB (5,299 words) - 17:42, 19 August 2024
attention is studies that validated that its gene, EPHX3, was hypermethylated on CpG sites in its Promoter (genetics) in human prostate cancer tissues, particularly...
9 KB (1,143 words) - 05:58, 17 June 2024
Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5' A: a novel oligonucleotide synthesized by interferon-treated L cell extracts. Cell 13:565–572...
12 KB (1,176 words) - 20:31, 10 January 2024
dehydrogenase - cortisone alpha-reductase - cosmid - costunolide synthase - CpG - craniosynostosis - crp domain - Cu2+-exporting ATPase - cyclodeaminase...
23 KB (1,951 words) - 16:56, 2 September 2024
synthesis of long DNA structures by performing PCR on a pool of long oligonucleotides with short overlapping segments, to assemble two or more pieces of...
32 KB (4,102 words) - 05:25, 7 February 2024
this distribution was very similar to genomic distributions of genes and CpG motifs. The distribution of SINEs to genes was significantly more similar...
41 KB (5,252 words) - 08:25, 18 July 2024