ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. The...
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ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position...
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PDGFRB (section PDGFRB-ETV6 translocations)
mutations is the translocation of PDGFRB gene with the ETV6 gene (also termed ETS variant gene 6). The ETV6 gene codes for a transcription factor protein that...
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translocations between ETV6 and ACSL6 at different chromosome break points create various t(5:12)(q31;p13) ETV6-ACSL6 fusion genes encoding ETV6-ACSL6 fusion proteins...
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an acquired mutation, the ETV6-NTRK3 fusion gene. This gene results from a translocation of genetic material from the ETV6 gene located on the short arm...
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of cases are associated with a known genetic syndrome. Rare mutations in ETV6 and PAX5 are associated with a familial form of ALL with autosomal dominant...
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Technology-Enhanced Learning Tetraethyllead, a gasoline additive to make leaded gasoline ETV6, previously known as TEL, a gene Transporter erector launcher, a mobile missile...
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fusion gene, ETV6-NTRK3, plus individual cases exhibiting trisomy for chromosomes 8, 11, 17, or 20. The histology, association with the ETV6-NRTK3 fusion...
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ETV6 gene located in band one, three sub-band 2 on chromosome 12. The fusion gene product, ETV6-NTRK3, encodes a chimeric mutant protein, termed ETV6-NTRK3...
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The ETV6-NTRK3 fusion gene's product, ETV6-NTRK3 protein, contains the N-terminus of ETV6 that is responsible for its dimerization/polymerization ETV6, a...
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neoplasms with germline ANKRD26 mutation Myeloid neoplasms with germline ETV6 mutation Myeloid neoplasms with germline GATA2 mutation Acute myeloid leukaemia...
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This genetic abnormality is a balanced genetic translocation that forms a ETV6-NTRK3 fusion gene which appears involved in promoting the development and/or...
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thrombocytopenia Epstein syndrome (associated with giant platelet disorder) ETV6 related thrombocytopenia Fanconi anemia Filaminopathies A FYB related thrombocytopenia...
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fever Aschoff bodies Rabies Hydrophobia and negri bodies Gout Tophi MASC ETV6-NTRK3 Acute tubular necrosis Muddy brown casts Granulosa cell tumour Call-Exner...
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mutations in JAK2, ABL1, and FLT2 and chromosomal translocations that create the ETV6-ACSL6 fusion gene. Chronic eosinophilic leukemia, not otherwise specified...
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chromosomal translocations such as t(9;22) BCR-ABL, t(15;17) PML-RARA and t(12;21) ETV6-RUNX1 (TEL-AML1). Patient-specific MRD detection using immunoglobulin (IG)...
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HGNC:33834 Q6ZN32 5144 ETV4 HGNC:3493 P43268 5145 ETV5 HGNC:3494 P41161 5146 ETV6 HGNC:3495 P41212 5147 ETV7 HGNC:18160 Q9Y603 5148 EVA1A HGNC:25816 Q9H8M9...
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ENSG00000244405 Ets Known motif – High-throughput in vitro [219] DVCGGAWRY ETV6 ENSG00000139083 Ets Known motif – High-throughput in vitro [220] SCGGAASCGGAAGYR...
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is expressed is called a fusion protein. Chimeric gene De novo gene birth ETV6-NTRK3 gene fusion Exon shuffling Gene duplication Horizontal gene transfer...
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that is expressed in hematopoietic tissues and can associate with TEL1/ETV6". Blood. 95 (11): 3341–8. doi:10.1182/blood.V95.11.3341. PMID 10828014. Gu...
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which complete genome data are available. JAK2 gene fusions with the TEL(ETV6) (TEL-JAK2) and PCM1 genes have been found in patients suffering leukemia...
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for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase". Molecular and Cellular Biology. 24 (11): 4685–4695...
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den Berghe H, Marynen P (1997). "Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid...
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end of JAK2. The oligomerisation domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine kinase domain of JAK2, and as result...
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factor 1 receptor, DCTN1, DNM1, Dock180, Dystroglycan, EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand...
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transcriptional repressor and interacts physically and functionally with TEL (ETV6)". J. Biol. Chem. 278 (17): 15412–20. doi:10.1074/jbc.M300592200. PMID 12588862...
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Douet-Guilbert N, Morel F, Le Bris MJ, Basinko A, De Braekeleer M (August 2012). "ETV6 fusion genes in hematological malignancies: a review". Leukemia Research...
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(2002). "Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature". Cancer...
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Late B Lymphopoiesis". Retrieved 2019-01-08. "Molecular role of the PAX5‐ETV6 oncoprotein in promoting B‐cell acute lymphoblastic leukemia". Retrieved...
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t(12;21) (p13.1;q22) causes the fusion of the ETS variant 6 (ETV6) and RUNX1 genes results in ETV6-RUNX1 gene fusion and is the most common genetic aberration...
26 KB (2,849 words) - 18:58, 20 November 2023