nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs)...

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a...

they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many genes. Additionally, estrogens bind to and activate rapid-signaling...

Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonists/antagonists (ERAAs), are a class of drugs that act on estrogen receptors...

Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear...

effects in the body. They act by blocking the estrogen receptor (ER) and/or inhibiting or suppressing estrogen production. Antiestrogens are one of three...

caused by a defective estrogen receptor (ER) – specifically, the estrogen receptor alpha (ERα) – that results in an inability of estrogen to mediate its biological...

Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is...

Membrane estrogen receptors (mERs) are a group of receptors which bind estrogen. Unlike nuclear estrogen receptors, which mediate their effects via slower...

nuclear receptors include members of subfamily 3, such as the androgen receptor, estrogen receptors, glucocorticoid receptor, and progesterone receptor. It...

with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones. There are three human estrogen related receptors: ERRα...

studied steroid hormone receptors are members of the nuclear receptor subfamily 3 (NR3) that include receptors for estrogen (group NR3A) and 3-ketosteroids...

A selective estrogen receptor degrader or downregulator (SERD) is a type of drug which binds to the estrogen receptor (ER) and, in the process of doing...

unknown cause or who are pregnant. Clomifene is in the selective estrogen receptor modulator (SERM) family of medication and is a nonsteroidal medication...

cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive,...

intracellular, as in the case of steroid hormone receptors.[citation needed] Selective estrogen receptor modulators (SERMs) are an important class of hormonal...

sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. It is also...

among others. Estrogens are agonists of the estrogen receptors, the biological targets of endogenous estrogens like estradiol. They have important effects...

of selective estrogen receptor modulators (SERMs) became evident. The first SERM, tamoxifen, was originally developed as an anti-estrogen contraceptive...

cancer Estrogen deprivation therapy for women with estrogen receptor-positive breast cancer High-dose estrogen therapy for women with estrogen receptor-positive...

a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). It has estrogenic effects in bone...

loss of bone mass due to a relative estrogen deficiency. The estrogen receptor, as well as the progesterone receptor, have been detected in the skin, including...

Endocrine therapy is a common treatment for estrogen receptor positive breast cancer. However, resistance to this therapy can develop, leading to relapse...

selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer [30] Fulvestrant-3 boronic acid (ZB716) – estrogen receptor antagonist...

is a selective estrogen receptor degrader (SERD) and was first-in-class to be approved. It works by binding to the estrogen receptor and destabilizing...

G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene...

are estrogens, or agonists of the estrogen receptor, the biological target of estrogens like estradiol. Compared to estradiol, certain estrogens in CEEs...

production of estrogen or block the action of estrogen on receptors. In contrast to premenopausal women, in whom most of the estrogen is produced in...

agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic activity, mostly at high...

found to play a direct, augmenting role as well, as it increases estrogen receptor (ER) expression in breast stromal (connective) tissue, while IGF-1...