Forkhead box protein O1 (redirect from FOXO1 (gene))
box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription...
28 KB (3,343 words) - 18:02, 7 November 2023
have the PAX3-FOXO1 fusion there needs to be a recombination event that translocates part of chromosome 13 to chromosome 2, and for PAX7-FOXO1 fusion there...
11 KB (1,302 words) - 06:32, 1 December 2023
results in a fusion of the PAX3 gene with FOXO1, while the t(1;13) translocation involves the fusion of PAX7 with FOXO1. PAX3 has a demonstrated role in muscle...
50 KB (5,957 words) - 04:39, 6 June 2024
FOXO1 genes to generate a PAX3-FOXO1 fusion gene that expresses a PAX3-FOXO1 fusion transcript encoding a PAX3-FOXO1 fusion protein. PAX3 and FOXO1 encode...
35 KB (4,308 words) - 04:26, 25 July 2024
Th17 pathogenic (section Foxo1)
factor Foxo1. Foxo1 inhibits hallmark Th17 transcription factor RORγt from enhancing the expression of the IL-1 and IL-23 receptors. Therefore, the Foxo1 deficient...
12 KB (1,243 words) - 09:09, 19 March 2024
liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)...
77 KB (9,064 words) - 19:20, 25 July 2024
results in a complex relay of signals in the osteoblasts culminating in FoxO1/ Creb and ATF4 dependent transcriptional events. Following the 2008 findings...
129 KB (13,890 words) - 08:46, 17 July 2024
liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)...
151 KB (15,122 words) - 19:41, 27 July 2024
liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)...
95 KB (10,068 words) - 19:15, 30 July 2024
spilanthol inhibits the activation of several transcription factors (NFκB, ATF4, FOXO1, IRF1, ETS1, and AP-1) which may explain the effect of spilanthol on gene...
6 KB (457 words) - 13:47, 25 January 2024
liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)...
111 KB (10,913 words) - 18:34, 30 July 2024
nutritional and hormonal sensor – forkhead/winged helix transcription factor Foxo1 that mediates the action of insulin, glucagon, estrogen, bioactive functional...
10 KB (1,073 words) - 13:51, 13 October 2023
about half of their beta cells. Fatty acids in the beta cells activate FOXO1, resulting in apoptosis of the beta cells. The disposition index drops and...
113 KB (12,159 words) - 17:06, 29 July 2024
rhabdomyosarcoma, as tumors of this subtype are unified by their lack of a PAX3-FOXO1 fusion oncogene (or other PAX fusions seen in alveolar rhabdomyosarcoma)...
34 KB (3,763 words) - 20:53, 6 January 2024
2011). "Dehydroepiandrosterone-induced phosphorylation and translocation of FoxO1 depend on the mineralocorticoid receptor". Hypertension. 58 (3): 471–8....
42 KB (3,935 words) - 04:01, 30 April 2024
insulin is present is the activation of SIRT1, which inhibits FoxO1. Specifically, FoxO1 is repressed from localizing in the nucleus by deacetylation in...
16 KB (1,825 words) - 01:06, 9 May 2024
thymus), FOXN2, FOXN3 (cell cycle checkpoints; widely expressed), FOXN4 FOXO1 (widely expressed: muscle, liver, pancreas), FOXO3 (apoptosis, erythroid...
8 KB (874 words) - 23:04, 18 August 2023
1111/dth.12483. PMID 28295859. Melnik BC (July 2011). "Isotretinoin and FoxO1: A scientific hypothesis". Dermato-Endocrinology. 3 (3): 141–165. doi:10...
74 KB (7,688 words) - 21:13, 25 July 2024
ENSG00000139445 Forkhead Known motif – In vivo/Misc source [275] WHNWRRNGACGCYATNHM FOXO1 ENSG00000150907 Forkhead Known motif – High-throughput in vitro [276] RTAAACATGTTTAC...
374 KB (81 words) - 02:10, 23 September 2023
experienced gestational sleep fragmentation were found to have Foxo1 misregulation. Foxo1 plays a critical role in monitoring insulin signaling in the liver...
21 KB (2,844 words) - 18:10, 12 July 2024
associated protein 6, L-DOPA, EFCAB6, Epidermal growth factor receptor, FOXO1, GAPDH, Gelsolin, GNB2L1, GSK3B, HDAC1, HSP90AA1, HTATIP, MAGEA11, MED1...
87 KB (9,375 words) - 15:11, 10 July 2024
affinity for the antigen. The dark zone proliferation program is regulated by FoxO1 and cyclin D3. These two genes are down-regulated by strong BCR signals...
22 KB (2,792 words) - 06:20, 3 March 2024
several other genes including MEF2B, STAT6, EP300, ARID1A, SLC22A2, CARD11, FOXO1, GNA12, B2M (i.e. the gene for beta-2 microglobulin), and SGK1. Except for...
67 KB (7,967 words) - 20:38, 20 July 2024
HGNC:5281 P32314 5820 FOXN3 HGNC:1928 O00409 5821 FOXN4 HGNC:21399 Q96NZ1 5822 FOXO1 HGNC:3819 Q12778 5823 FOXO3 HGNC:3821 O43524 5824 FOXO3B HGNC:3822 A0A2Z4LIS9...
277 KB (17 words) - 15:46, 9 May 2024
as they stabilize Notch/Hes binding. Research has shown that knockout of FOXO1 in mice increases MyoD expression, altering the distribution of fast-twitch...
24 KB (2,738 words) - 04:06, 17 June 2024
liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)...
39 KB (4,295 words) - 19:58, 17 April 2024
example is the Forkhead family transcription factors (FoxO/FH), of which FKHR/FoxO1, FKHRL1/FoxO3 and AFX/FoxO4 are directly phosphorylated by Akt. This phosphorylation...
37 KB (4,145 words) - 08:04, 3 July 2024
liposarcoma t(12 DDIT3; 16 FUS) Desmoplastic small-round-cell tumor t(11 WT1; 22 EWS) Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)...
14 KB (1,341 words) - 22:41, 10 April 2024
a single case of rhabdomyosarcoma tumor was found express co-amplified FOXO1 gene at 13q14 and FGFR1 gene at 8p11, i.e. t(8;13)(p11;q14), suggesting...
44 KB (5,003 words) - 08:59, 15 July 2024
of genetic subtype; and either activation of Akt or compound deletion of FoxO1/3/4 reduced leukemic cell growth in a mouse model. Two studies show that...
35 KB (3,831 words) - 00:20, 19 July 2024