Zinc finger protein GLI2 also known as GLI family zinc finger 2 is a protein that in humans is encoded by the GLI2 gene. The protein encoded by this gene...

holoprosencephaly. However, SHH activates downstream molecules of Gli2 and Gli3. Mutant Gli2 and Gli3 embryos have abnormal development of incisors that are...

are was unclear. By mutating the proteins Gli2 and Gli3, which were especially studied, it was found that Gli2 and Gli3 contain both activation and repression...

also indicates that Gli1 and/or Gli2 overexpression is vital in BCC formation. Co-overexpression of Gli1 with Gli2 and Gli2 with Gli3 leads to transgenic...

Lines, a North-American bus carrier Volkswagen GLI, an automobile GLI1, GLI2, GLI3, glioma-associated family of transcription factors This disambiguation...

in the specification of the neural crest, with the transcription factor Gli2 playing a key role. Outside of the tightly regulated network of neural crest...

good prognosis, others intermediate: SHH group, PTCH1/SMO/SUFU mutation, GLI2 amplification, or MYCN amplification Poor prognosis: Group 3, MYC amplification...

inhibits the Smoothened receptor. Activated smoothened in turn causes Gli1, Gli2, and Gli3 to be translocated into the nucleus where they activate target...

Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, et al. (May 2008). "GLI2-specific transcriptional activation of the bone morphogenetic protein/activin...

recognizes H3K27me3. This occurs in a Gli-dependent manner, as Gli1 and Gli2 are downstream effectors of the Hedgehog signaling pathway. In culture, Bmi1...

signaling pathway. SMO inhibition causes the transcription factors GLI1 and GLI2 to remain inactive, which prevents the expression of tumor mediating genes...

ENSG00000111087 C2H2 ZF Known motif – In vivo/Misc source [303] SMCCHCCCA GLI2 ENSG00000074047 C2H2 ZF Known motif – High-throughput in vitro [304] GMCCACMCANVNHB...

of the GLI transcription factors (Process "5"): the activators Gli1 and Gli2 and the repressor Gli3. The sequence of molecular events that connect SMO...

Gli factors that are essential for limb development: Gli1, Gli2 and Gli3. Without Shh, Gli2 and Gli3 are processed to a repressor form and travel to the...

the cell to abruptly switch states at precise Shh concentrations. gli1 and gli2 transcription is activated by Shh, and their gene products act as transcriptional...

HGNC:4315 Q53GS7 6282 GLG1 HGNC:4316 Q92896 6283 GLI1 HGNC:4317 P08151 6284 GLI2 HGNC:4318 P10070 6285 GLI3 HGNC:4319 P10071 6286 GLI4 HGNC:4320 P10075 6287...

leading to activation of the Gli family of transcription factors (GLI1, GLI2, and GLI3). In this context Shh acts as a morphogen - it induces cell differentiation...

of the lungs, trachea and oesophagus. These are BMP-4, BMPR1A and BMPR1B, Gli2 and Gli3, sonic hedgehog and NK2 homeobox 1. It is highly likely that tracheal...

Wojtek; Lee, Joon S.; Stephen, Daniel; Joyner, Alexandra L. (October 2002). "Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation...

malformation syndrome (HBMS) 14q32 AD Hemifacial microsomia SIX3, SHH, PTCH1, GLI2 AD Holoprosencephaly types 1, 2, 3, 7, 9 IKBKG XLD Incontinentia pigmenti...

genes. GANT-61 effectively reduced the DNA-binding affinity of GLI1 and GLI2 in multiple cancer cell lines, including rhabdomyosarcoma, osteosarcoma,...

members of the family; Gli1, Gli2 and Gli3 which are all transcription factors mediating the Hh pathway. The GLI1, GLI2, and GLI3 genes encode transcription...

ectrodactyly, and bilateral cleft of lip and palate: exclusion of SHH, TGIF, SIX3, GLI2, TP73L, and DHCR7 as candidate genes". American Journal of Medical Genetics...

Ribeiro LA, de Miranda E, Richieri-Costa A, Murray JC (December 2006). "GLI2 mutations in four Brazilian patients: how wide is the phenotypic spectrum...

CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, Yoder BK (October 2005). "Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein...

(CD115) FORSE-1 G alpha16 GDF3 GFPM Giant granules of beige C57B1/6 (bg) mice Gli2 Gli3 glial fibrillary acidic protein glycoprotein IB GSTA1 HAS2 gene expression...

609637; ZIC2 Holoprosencephaly-7; 610828; PTCH1 Holoprosencephaly-9; 610829; GLI2 Holt–Oram syndrome; 142900; TBX5 Homocystinuria due to MTHFR deficiency;...

Regl G, Ikram MS, et al. (2004). "FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma". J. Invest. Dermatol...

Matsumoto N, Fujimoto M, Kato R, Niikawa N (1997). "Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization". Genomics. 36 (1): 220–1...

epithelium in mice such as Bmp4, Bmp7, Dlx2, Dlx5, Fgf1, Fgf2, Fgf4, Fgf8, Lef1, Gli2, and Gli3 are also potential candidates. Based on existing evidence, it seems...