HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88;...
34 KB (4,113 words) - 16:29, 29 July 2024
Statin (redirect from HMG-CoA reductase inhibitor)
Statins (or HMG-CoA reductase inhibitors) are a class of medications that reduce illness and mortality in people who are at high risk of cardiovascular...
134 KB (13,062 words) - 13:35, 14 October 2024
β-methylglutaconyl-CoA (MG-CoA) and β-hydroxy β-methylbutyryl-CoA (HMB-CoA). HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid,...
8 KB (959 words) - 23:27, 8 December 2021
Smith–Lemli–Opitz syndrome (redirect from 7-dehydrocholesterol reductase deficiency)
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonate, this is an early step in the mevalonate pathway catalyzed by HMG-CoA reductase. Through a complicated...
56 KB (6,560 words) - 14:53, 22 October 2024
Mevalonate pathway (redirect from HMG-CoA reductase pathway)
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea...
9 KB (756 words) - 21:39, 21 November 2023
In molecular biology, the HMG-CoA reductase family is a family of enzymes which participate in the mevalonate pathway, the metabolic pathway that produces...
4 KB (480 words) - 03:33, 29 November 2023
The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia...
23 KB (2,423 words) - 18:34, 11 September 2024
harm the fetus. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol...
100 KB (9,451 words) - 00:33, 30 September 2024
levels of cholesterol) stop the production of mevalonate by inhibiting HMG-CoA reductase. Mevalonic acid is very soluble in water and polar organic solvents...
4 KB (255 words) - 16:38, 17 August 2024
consistent findings on physical examination, the presence of anti HMG-CoA reductase antibodies in a person with myopathy, evidence of muscle breakdown...
12 KB (1,349 words) - 18:07, 19 March 2024
Statins act by inhibiting the enzyme hydroxymethylglutaryl CoA reductase (HMG-CoA-reductase) in the liver. In response, the liver produces more LDL receptors...
48 KB (5,465 words) - 14:08, 6 September 2024
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway, which is essential for cholesterol biosynthesis. It also takes a similar role in...
10 KB (879 words) - 20:31, 15 September 2024
3-hydroxy-3-methylglutaryl (HMG) coenzyme A reductase. HMG-CoA reductase, the rate-limiting enzyme of the HMG-CoA reductase pathway, the metabolic pathway...
33 KB (3,284 words) - 00:33, 1 September 2024
the cytosol is first converted to cytosolic β-hydroxy-β-methylglutaryl-CoA (HMG-CoA), which can then be directed for cholesterol synthesis (Rudney 1957)...
5 KB (1,036 words) - 19:57, 29 August 2024
and blocking the enzyme farnesyl diphosphate synthase (FPPS) in the HMG-CoA reductase pathway (also known as the mevalonate pathway). Bisphosphonates that...
30 KB (3,429 words) - 02:49, 1 January 2024
medication class of statins. Like other statins, it is an inhibitor of HMG-CoA reductase, the enzyme that catalyses the first step of cholesterol synthesis...
11 KB (1,001 words) - 20:19, 24 October 2024
harm the baby. Like all statins, rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol...
42 KB (3,486 words) - 00:32, 30 September 2024
subsequently converted to HMG-CoA by methylglutaconyl-CoA hydratase. HMG-CoA is then cleaved into acetyl-CoA and acetoacetate by HMG-CoA lyase or used in the...
106 KB (9,982 words) - 15:37, 7 January 2024
an isoprenoid precursor. IPP is an intermediate in the classical, HMG-CoA reductase pathway (commonly called the mevalonate pathway) and in the non-mevalonate...
4 KB (247 words) - 19:03, 9 July 2024
week follow-up. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin...
5 KB (356 words) - 08:26, 9 September 2024
by a complex 37-step process. This begins with the mevalonate or HMG-CoA reductase pathway, the target of statin drugs, which encompasses the first 18...
80 KB (8,640 words) - 20:17, 27 October 2024
subsequently converted to HMG-CoA by methylglutaconyl-CoA hydratase. HMG-CoA is then cleaved into acetyl-CoA and acetoacetate by HMG-CoA lyase or used in the...
27 KB (4,132 words) - 00:11, 7 September 2024
the HMG-CoA reductase making it unavailable for HMG-CoA. Cerivastatin is a pure synthetic drug, produced to create a more potent inhibitor of HMG-CoA reductase...
16 KB (1,781 words) - 20:57, 4 September 2024
Methylcrotonyl CoA carboxylase (EC 6.4.1.4, MCC) (3-methylcrotonyl CoA carboxylase, methylcrotonoyl-CoA carboxylase) is a biotin-requiring enzyme located...
9 KB (1,329 words) - 07:42, 3 June 2024
delivery of intestinal cholesterol to the liver. Simvastatin is an HMG-CoA reductase inhibitor or statin. It works by blocking an enzyme that is necessary...
11 KB (920 words) - 23:32, 30 March 2024
β-methylbutyric acid (HMB) and β-methylcrotonoyl-CoA (MC-CoA). It can be metabolized into HMB, MC-CoA, and HMG-CoA in humans. This reaction is catalyzed by an...
2 KB (679 words) - 18:22, 15 September 2024
of HMG-CoA reductase through competitive inhibition. HMG-CoA reductase, an enzyme found in hepatocytes, is responsible for the conversion of HMG-CoA to...
46 KB (5,032 words) - 09:46, 11 August 2024
not tolerated. Statins competitively inhibit hydroxymethylglutaryl (HMG) CoA reductase which is used in the biosynthesis of cholesterol and they include...
30 KB (2,967 words) - 22:36, 25 September 2024
C20H32. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being a primary intermediate...
5 KB (464 words) - 17:39, 20 October 2024
harm the fetus. Like all statins, pravastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver that plays a role in producing cholesterol...
14 KB (1,096 words) - 19:44, 21 September 2024