nuclear localization sequences (NLS). Importin has two subunits, importin α and importin β. Members of the importin-β family can bind and transport cargo...

complexes. Importin beta is a variety of karyopherin that facilitates the transport of cargo proteins into the nucleus. First, it is binding importin alpha...

Importin alpha, or karyopherin alpha refers to a class of adaptor proteins that are involved in the import of proteins into the cell nucleus. They are...

signals are recognized by importin α. Importin α contains a bipartite NLS itself, which is specifically recognized by importin β. The latter can be considered...

Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA2 gene. The import of proteins into the nucleus is a process that involves at...

Transportin-1 (or Importin-β 2) is a protein that in humans is encoded by the TNPO1 gene. This protein is a karyopherin which interacts with nuclear localization...

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene. Nucleocytoplasmic transport, a signal- and energy-dependent process...

called importins. Once the STAT dimer (bound to importins) enters the nucleus, a protein called Ran (associated with GTP) binds to the importins, releasing...

Importin subunit alpha-5 is a protein that in humans is encoded by the KPNA1 gene. Importin subunit alpha-5 has been shown to interact with KPNB1 and...

material with an NLS will be taken up by importins to the nucleus.[citation needed] Importation begins with Importin-α binding to the NLS sequence of cargo...

Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene. The transport of molecules...

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene. Nucleocytoplasmic transport, a signal- and energy-dependent process,...

Importin subunit alpha-6 is a protein that in humans is encoded by the KPNA5 gene. The transport of molecules between the nucleus and the cytoplasm in...

Importin subunit alpha-3, also known as karyopherin subunit alpha-4, is a protein that in humans is encoded by the KPNA4 gene. The nuclear import of karyophilic...

Importin-7 is a protein that in humans is encoded by the IPO7 gene. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins...

(RNP). At the early stage of infection, the RNP binds to the host cell's importin-α which transports it into the host cell nucleus, where the viral RNA is...

localization signal (NLS) are bound by importins and transported into the nucleus. Inside the nucleus, RanGTP binds to importin and releases the import cargo....

by importins, while those transported from the nucleus to the cytoplasm carry nuclear export signals bound by exportins. The ability of importins and...

of the cell. The importin structure is composed of many alpha helices that integrate the protein into membranes. The role of importin is to move proteins...

surface of the chromosomes: it releases envelope components sequestered by importin β during early mitosis. Ran-GTP localizes near chromosomes throughout mitosis...

basis for the recognition of a nonclassical nuclear localization signal by importin beta". Molecular Cell. 10 (6): 1345–1353. doi:10.1016/S1097-2765(02)00727-X...

factors known as nuclear transport receptors, like karyopherins called importins to enter the nucleus and exportins to exit. Protein that must be imported...

on the VirE2 and VirD2, are recognised by the importin alpha protein, which then associates with importin beta and the nuclear pore complex to transfer...

the nuclear localization signal regions, which allows for the binding of importin β and calmodulin to SRY, facilitating its import into the nucleus. Once...

binding to the AHR (1.) leads to its translocation into the nucleus by importin-β, (2.) heterodimerization with ARNT and binding to the DNA at DREs, (3...

Importin-11 is a protein that in humans is encoded by the IPO11 gene. GRCh38: Ensembl release 89: ENSG00000086200 – Ensembl, May 2017 GRCm38: Ensembl release...

proteins that contain armadillo repeats include β-catenin, Sarm1 (SARM1), α-importin, plakoglobin, adenomatous polyposis coli (APC), and many others. The term...

RanGTPase would bind to the beta importin which removes it from the complex, followed by the removal of the alpha importin which is also bound to the RanGTPase...

factors (SAFs) from inhibitory interactions via the transport proteins importin β/α. The unbound SAFs then promote microtubule nucleation and stabilization...

specifically the inhibition of nuclear transport by importin α/β1. Several other drugs which inhibit importin α/β1 at therapeutic doses have failed clinical...