Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast, plant steroids are produced...

cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by...

are manufactured in cells from the sterols lanosterol (opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization...

the conversion of squalene to lanosterol. In fungi, lanosterol is then converted to ergosterol; in humans, lanosterol becomes cholesterol. However, as...

Lanosterol 14α-demethylase (CYP51A1) is the animal version of a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9)...

cycloartenol Lanosterol synthase (LAS), found in all animals and fungi, and occasionally in plants, which produces primarily lanosterol Sterols and triterpenes...

Synthase 1), and CYP51A1, lanosterol 14-α-demethylase, sometimes unofficially abbreviated to LDM according to its substrate (Lanosterol) and activity (DeMethylation)...

intermediate in the synthesis of the cell membrane sterol precursors lanosterol and cycloartenol, as well as saponins. It is formed when squalene is oxidized...

Similarly to other azole fungicides, prochloraz is an inhibitor of the enzyme lanosterol 14α-demethylase (CYP51A1), which is necessary for the production of ergosterol...

cucurbitane core, although in practice they are biosynthesised from either lanosterol (animals and fungi) or cycloartenol (plants) via the cyclization of squalene...

(vitamin E), dolichols, and squalene. Heme A has an isoprenoid tail, and lanosterol, the sterol precursor in animals, is derived from squalene and hence from...

synthesis of ergosterol from lanosterol by interfering with 14α-demethylase. Ergosterol is a smaller molecule than lanosterol; it is synthesized by combining...

Rimocidin Azole antifungals inhibit the conversion of lanosterol to ergosterol by inhibiting lanosterol 14α-demethylase. These compounds have a five-membered...

14,24(28)-trien-3beta-ol, formate, NADP+, and H2O. Although the lanosterol 14α-demethylase is present in a wide variety of organisms, the enzyme...

step towards cholesterol biosynthesis. Squalene leads to the creation of lanosterol, from which there are multiple pathways that lead to cholesterol biosynthesis...

from lanosterol. Ergosterol is absent in animals but is an essential component of the cell membranes of many fungi and protozoa, and so lanosterol 14α-demethylase...

products of lanosterol, dihydrolanosterol can be demethylated by mammal or yeast cytochrome P450 sterol 14alpha-demethylase. Lanosterol Obtusifoliol...

binding, while still allowing binding of the enzyme's natural substrate, lanosterol. Development of resistance to one azole in this way will confer resistance...

Barry (1968). Studies of the mechanism of action of 2,3-oxidosqualene-lanosterol cyclase: featuring enzymic cyclization of modified squalene oxides (Ph...

along with the known phytoconstituents lauric acid, β-sitosterol and lanosterol. Marshmallows are used in gardening as ornamental plants. The leaves,...

component of the fungal cell membrane, by inhibiting the P450 enzyme lanosterol 14-alpha demethylase. Clotrimazole may slow fungal growth or result in...

3-oxidosqualene. It then undergoes an enzyme-catalysed cyclisation to produce lanosterol, which can be elaborated into other steroids such as cholesterol and ergosterol...

the steroids of fungi and animals, which are, instead, produced from lanosterol. The biosynthesis of cycloartenol starts from the triterpenoid squalene...

Tocopherols Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Lanosterol Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic acid Betulinic...

Cultivated chaga developed a reduced number of phytosterols, particularly lanosterol, an intermediate in the synthesis of ergosterol and lanostane-type triterpenes...

Tocopherols Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Lanosterol Saponins Serratenediol Squalane Acids Oleanolic acid Ursolic acid Betulinic...

steps. This is followed by 19 additional steps to convert the resulting lanosterol into cholesterol. A human male weighing 68 kg (150 lb) normally synthesizes...

squalene and then folded up and formed into a set of rings to make lanosterol. Lanosterol can then be converted into other steroids such as cholesterol and...

inhibits the fungal-mediated synthesis of ergosterol, via inhibition of lanosterol 14α-demethylase. Because of its ability to inhibit cytochrome P450 3A4...

pyrophosphate. Squalene is then processed biosynthetically to generate either lanosterol or cycloartenol, the structural precursors to all the steroids. Sesquarterpenes...