Proliferating cell nuclear antigen (redirect from PCNA)
antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer...
53 KB (6,161 words) - 09:27, 11 November 2024
acts as a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) and is in Phase I clinical trials at City of Hope as of August 2023 for...
6 KB (572 words) - 16:30, 23 September 2024
DNA mismatch repair (section PCNA β-sliding clamp)
(PCNA), in an orientation-specific manner, such that one face of the donut-shape protein is juxtaposed toward the 3'-OH end at the nick. Loaded PCNA then...
35 KB (4,179 words) - 19:39, 22 September 2024
proliferating cell nuclear antigen (PCNA). The N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated...
23 KB (2,044 words) - 07:04, 10 March 2024
P21 (section PCNA inhibition)
binding region on PCNA, binding of p21 to this region is proposed to block the binding of processivity factors necessary for PCNA dependent S-phase DNA...
34 KB (3,978 words) - 08:00, 23 February 2024
cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor C, through its role as the clamp loader for PCNA (which involves catalysing...
2 KB (259 words) - 21:21, 11 December 2023
both PCNA and RFC, and produces mostly ligated DNA products. It is also found that under one condition where DNA polymerase epsilon require PCNA and RFC:...
3 KB (336 words) - 09:50, 4 November 2023
A Ramachandran plot generated from human PCNA, a trimeric DNA clamp protein that contains both β-sheet and α-helix (PDB ID 1AXC). The red, brown, and yellow...
16 KB (1,761 words) - 05:00, 29 October 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
15 KB (1,603 words) - 16:54, 15 June 2024
antigen (PCNA). The PCNA ring has polarity with surfaces that interact with DNA polymerases and tethers them securely to the DNA template. PCNA-dependent...
119 KB (14,646 words) - 22:02, 3 July 2024
cell nuclear antigen (PCNA). Under normal circumstances, PCNA bound to polymerases replicates the DNA. At a site of lesion, PCNA is ubiquitinated, or modified...
129 KB (15,900 words) - 22:25, 12 October 2024
by the FEN1 and it creates a functional continuous double strand of DNA. PCNA simulates enzymatic functions of proteins for both FEN1 and DNA ligase. The...
34 KB (4,470 words) - 07:49, 11 November 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
37 KB (4,208 words) - 04:07, 27 October 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
22 KB (2,602 words) - 02:15, 26 September 2024
The assembled human DNA clamp, a trimer of the protein PCNA...
60 KB (7,286 words) - 00:09, 20 November 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
100 KB (11,168 words) - 03:44, 19 November 2024
Wright JT (June 2018). "2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High...
133 KB (13,919 words) - 05:15, 18 November 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
28 KB (3,076 words) - 03:33, 27 October 2024
The replisome is composed of a number of proteins including helicase, RFC, PCNA, gyrase/topoisomerase, SSB/RPA, primase, DNA polymerase III, RNAse H, and...
32 KB (3,700 words) - 00:38, 1 January 2024
hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA). By preferentially modifying hemimethylated DNA, DNMT1 transfers patterns...
161 KB (18,392 words) - 13:19, 16 November 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
21 KB (2,342 words) - 16:59, 19 May 2024
Cynopa pyrrhogaster, this transition was shown to involve expression of PCNA, a DNA polymerase delta auxiliary protein involved in DNA replication and...
36 KB (3,836 words) - 18:50, 24 October 2024
Bittl JA, Byrne JG, Fletcher BJ, et al. (November 2014). "2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management...
107 KB (10,940 words) - 23:22, 12 November 2024
Proliferating cell nuclear antigen (PCNA) is a protein involved in post-replication MMR. It has been shown that PCNA binds to the MutSβ heterodimer via...
17 KB (2,080 words) - 11:40, 15 November 2024
rennlist.com. Retrieved 10 August 2017. "991.1 GT3 COG: Our Meeting with PCNA/PAG plus Porsche's Official Announcement". rennlist.com. Retrieved 10 August...
91 KB (10,450 words) - 09:02, 19 November 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
80 KB (8,640 words) - 20:17, 27 October 2024
the other subunits that interact with Proliferating Cell Nuclear Antigen (PCNA), which is a DNA clamp that allows Pol δ to possess processivity. Pol ε is...
59 KB (7,090 words) - 06:49, 30 June 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
181 KB (17,370 words) - 08:34, 11 November 2024
Blankenship JC, Dallas AP, et al. (December 2012). "2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable...
44 KB (3,709 words) - 08:54, 8 September 2024
"Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High...
45 KB (5,126 words) - 12:30, 17 November 2024