Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine...

that certain SNPs in the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene can...

analysis. CTLA-4 was confirmed as the main locus for thyroid autoantibodies. PTPN22 is the most recently identified immune-regulatory gene associated with autoimmune...

of susceptibility to lupus erythematosus). In recent studies, the gene PTPN22 has emerged as a significant factor linked to various autoimmune diseases...

genetic factors that predispose disease onset including HLA-B27 and the PTPN22 genotype. Recent evidence has pointed to reactivation of herpes simplex...

thyrotropin receptor, protein tyrosine phosphatase nonreceptor type 22 (PTPN22), and cytotoxic T-lymphocyte–associated antigen 4, among others. Since Graves...

transplanted human tissue. One focus of her recent work has been the phosphatase PTPN22, a variant form of which is associated with increased risk of autoimmune...

protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (1p13.2 - PTPN22), "CT/TT" genotype showed significant association with anti-topo I. The...

people with GPA. Several genes involved in the immune system including PTPN22, CTLA4, and human leukocyte antigen genes may influence the risk of developing...

ability to develop immune tolerance to insulin, a key autoantigen in T1D. PTPN22: This gene encodes a protein tyrosine phosphatase involved in T-cell receptor...

phosphatase ("Lyp", gene product of PTPN22) is possibly associated with the increased autoimmune diseases associated with PTPN22 mutations. GRCh38: Ensembl release...

CD40, cytokine signaling, lymphocyte receptor activation threshold (e.g., PTPN22), and innate immune activation—appear to have less influence than HLA mutations...

PMID 15132716. Brand O, Gough S, Heward J (October 2005). "HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?". Expert Reviews in Molecular...

Prajapati, Hiral; Marfatia, Y.S.; Begum, Rasheedunnisa (2008). "Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population"...

Smith KG (2009). "Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis". BMC Medical Genetics. 10: 121. doi:10...

Q99952 13139 PTPN20 HGNC:23423 Q4JDL3 13140 PTPN21 HGNC:9651 Q16825 13141 PTPN22 HGNC:9652 Q9Y2R2 13142 PTPN23 HGNC:14406 Q9H3S7 13143 PTPRA HGNC:9664 P18433...

samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4". American Journal of Human Genetics. 77 (6): 1044–1060...

cause inherited disorders, including, for example, Type 1 diabetes (e.g., PTPN22, TCF1 (HCF-1A)), hypertension (e.g., LDL, LDLR, LPL), Marfan syndrome (e...

followed by conversion of pAEA into NAE 20:4 (AEA) by phosphatases such as PTPN22 and SHIP1. The effects of NAE 20:4 (AEA) and another endocannabinoid...

4 + 107146630 107147268 USP48 84196 241 631 89.0% 1 + 22014725 22015355 PTPN22 26191 227 281 90.0% 1 - 114365307 114365587 PSPH 5723 220 605 90.6% 7 -...

arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis and Rheumatism...

et al.: Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis, American J. Hum. Genetics...