RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes...

mice. The following year self-amplifying mRNA was developed by including both a viral antigen and replicase encoding gene. The method was used in mice...

The RNA world is a hypothetical stage in the evolutionary history of life on Earth, in which self-replicating RNA molecules proliferated before the evolution...

something particularly prevalent in RNA viruses over DNA viruses due to the enzyme used (replicase, or RNA-dependent RNA polymerase.) DI genomes typically...

transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...

RNA chain of only 218 nucleotides that is able to be reproduced by the RNA replication enzyme RNA-dependent RNA polymerase, also called RNA replicase...

replicate viral RNA molecules (reverse transcriptases and RNA replicases) lack molecular proofreading (3′ to 5′ exonuclease) activity, and that RNA sequences...

viral enzyme RNA-dependent RNA polymerase (RdRp), also called RNA replicase. Positive-strand RNA viruses have genomes that can function as mRNA, so transcription...

properties of RNA". Visser CM (1984). "Evolution of biocatalysis 1. Possible pre-genetic-code RNA catalysts which are their own replicase". Origins of...

codon. The 4 genes encode a replicase (with methyltransferase [MT] and RNA helicase [Hel] domains), an RNA-dependent RNA polymerase, a so-called movement...

translating viral mRNA into protein. For RNA-based phages, RNA replicase is synthesized early in the process. Proteins modify the bacterial RNA polymerase so...

final ORF encodes the replicase gene. The protein product of this sequence yields a RNA-dependent RNA polymerase. The replicase gene is controlled by...

to form a multi-protein replicase-transcriptase complex (RTC). The main replicase-transcriptase protein is the RNA-dependent RNA polymerase (RdRp). It is...

genetic material is single-stranded or double-stranded. All RNA viruses use their own RNA replicase enzymes to create copies of their genomes.: 79  Reverse...

transcriptase and replicase functions, the viral L protein is also thought to have an endonuclease activity that cleaves cellular messenger RNAs (mRNAs) for the...

three accessory proteinases which are mainly involved in expressing the replicase gene. These proteinases are also responsible for activating or inactivating...

shares common features with retroviral reverse transcriptases, viral RNA replicases and bacteriophage B-family DNA polymerases. TERT proteins from many...

presence of various terrestrial minerals. RNA replicase can function as both code and catalyst for further RNA replication, i.e. it can be autocatalytic...

the viral RNA polymerase (Replicase) via a complementary −ssRNA as a template and translated as a separate short mRNA. This short subgenomic RNA is additionally...

Alternatively, the siRNAs and microRNAs generated during viral infections may have been amplified by helper virus replicases, whereby these molecules...

the conversion of the negative-sense RNA genome into mRNA to be translated into viral proteins. As a replicase, the protein complex is responsible for...

either RNA or DNA genomes) that encode an RNA-dependent DNA polymerase. RNA-dependent RNA polymerase (RdRp), also called RNA replicase, produces RNA (ribonucleic...

presumably in other cells as well. Mutations in the mouse hepatitis virus RNA replicase that cause partial resistance to remdesivir were identified in 2018...

its effect on cell metabolism, including the first description of an RNA replicase. After his PhD, Baltimore returned to MIT for postdoctoral research...

"Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene". Nature. 260 (5551): 500–7. Bibcode:1976Natur...

"Complete nucleotide-sequence of bacteriophage MS2-RNA - primary and secondary structure of replicase gene". Nature. 260 (5551): 500–507. Bibcode:1976Natur...

structure of β-CoV genome is similar to that of other CoVs, with an ORF1ab replicase polyprotein (rep, pp1ab) preceding other elements. This polyprotein is...

RNAs (siRNA) and microRNA (miRNA), are approximately 21–23 nucleotides in length. The fragments integrate into a multi-subunit protein called the RNA-induced...

The internal structure of MRV has been fully reconstructed. λ3 is the RNA replicase, whereas μ2 is a transcription factor. As stated in the beginning of...

and RNA replicase will give rise to RNA molecules which replicate, mutate, and evolve. 1974 – Leslie Orgel showed that RNA can replicate without RNA-replicase...