activity is also post-translationally regulated by cytoplasmic deacetylase SIRT2. SIRT2-mediated deacetylation and activation of G6PD stimulates oxidative branch...
11 KB (1,112 words) - 02:02, 12 June 2024
extracellular oxidative stimuli to decrease G6PD acetylation in a SIRT2-dependent manner. The SIRT2-mediated deacetylation and activation of G6PD stimulates pentose...
23 KB (2,413 words) - 18:07, 8 June 2024
compartments: SIRT1, SIRT6 and SIRT7 are predominantly in the nucleus, SIRT2 in the cytoplasm, and SIRT3, SIRT4 and SIRT5 in the mitochondria. Research...
28 KB (2,324 words) - 06:32, 27 May 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
266 KB (31,209 words) - 18:17, 22 June 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
22 KB (2,409 words) - 23:24, 20 June 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
66 KB (7,918 words) - 11:57, 27 June 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
25 KB (2,888 words) - 05:39, 22 March 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
56 KB (6,208 words) - 10:26, 5 June 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
51 KB (5,769 words) - 05:18, 24 June 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
103 KB (12,754 words) - 16:50, 24 June 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
23 KB (3,234 words) - 08:22, 7 February 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
56 KB (6,953 words) - 07:19, 19 May 2024
BUB1B has been shown to interact with: AP2B1 BRCA2 BUB3 CDC20 MAD2L1 CBP SIRT2 PLK1 PP2A-B56 HDAC1 HDAC2 / HDAC3 SNCG GRCh38: Ensembl release 89: ENSG00000156970...
20 KB (2,313 words) - 21:43, 22 December 2023
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
57 KB (7,187 words) - 23:45, 26 May 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
36 KB (4,169 words) - 11:36, 21 April 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
10 KB (921 words) - 20:35, 10 March 2024
Mostly cytoplasm liver, spleen, kidney – – – III sirtuins in mammals (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7) – – – – – – Sir2 in the yeast S. cerevisiae...
31 KB (3,181 words) - 04:49, 11 March 2024
the deacetylation of residue K100 in the PGAM active site by sirtuin 2 (SIRT2) under conditions of oxidative stress. This deacetylation activates PGAM...
8 KB (1,061 words) - 23:58, 3 March 2023
Q9H106 14812 SIRPG HGNC:15757 Q9P1W8 14813 SIRT1 HGNC:14929 Q96EB6 14814 SIRT2 HGNC:10886 Q8IXJ6 14815 SIRT3 HGNC:14931 Q9NTG7 14816 SIRT4 HGNC:14932 Q9Y6E7...
282 KB (17 words) - 07:55, 20 June 2024
causes an increase in both Sirt1 and Sirt2. Scientists were then interested in determining how increased Sirt1 and Sirt2 affected nuclear volume because it...
29 KB (3,823 words) - 23:42, 19 April 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
16 KB (1,863 words) - 12:00, 22 June 2024
conservation with other sirtuins, such as the ancestral yeast protein and human SIRT2. SIRT5 has been found to exhibit enzymatic activities as a deacetylase,...
7 KB (913 words) - 23:35, 3 March 2023
Borra MT, Denu JM, Verdin E (February 2003). "The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase". Molecular Cell. 11 (2): 437–444...
15 KB (1,738 words) - 07:16, 11 March 2024
Mitochondrial Oxidative Metabolism in Mice. Science. 342:1243417, 2013. SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating...
9 KB (931 words) - 10:15, 7 April 2024
0502738102. PMC 1183558. PMID 16076959. Jing E, Gesta S, Kahn CR (August 2007). "SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation"...
28 KB (3,343 words) - 18:02, 7 November 2023
Accumulation of these circles has been linked to premature aging. Sirtuin 2 (SIRT2), SIR2's human analog, has also been linked to age-related disease. SIR3...
19 KB (2,343 words) - 01:04, 3 December 2023
Xiong Y, Guan KL, Ye D (Jun 2014). "Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative...
8 KB (986 words) - 02:13, 29 March 2024
of mutant LRRK2 with microtubules, inhibition of deacetylases HDAC6 and Sirt2 through knockdown processes rescued both axonal transport and locomotor...
44 KB (5,725 words) - 00:49, 4 April 2024
reduced alpha-synuclein-mediated neurotoxicity. siRNA inhibition of SIRT2 Treatment with SIRT2 inhibiting siRNA leads to reduced alpha-synuclein neurotoxicity...
113 KB (13,392 words) - 02:52, 24 May 2024