Sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside, is a class of sulfolipids, specifically a class of sulfoglycolipids...

can't break down the sulfatides which results in all of the same MLD symptoms and progression. A 2011 study contended sulfatide is not completely responsible...

rise in the production of various lipids – cholesterol, cerebroside, and sulfatide. As researchers began to do postnatal research, they found that myelinogenesis...

important members of the sulfur cycle. Other important sulfolipids include sulfatide and seminolipid, each of which are sulfated glycolipids. Sulfolipids have...

is a form of lysosomal storage disease resulting in a proliferation of sulfatide. It is caused by a genetic insufficiency of sulfatase enzymes. Metachromatic...

(July 2023). "Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson's disease primate model". npj Parkinson's...

hydrolysis of sulfatides by arylsulfatase A. It is known by many different names, such as, sphingolipid activator protein-1 (SAP-1), sulfatide activator protein...

A (ASA or sometimes ARSA), also called sulfatide sulfatase. ASA is responsible for the breakdown of sulfatides, sphingolipids present in neuronal membranes...

galactosphingolipid galactocerebroside (GalC) and its sulfated derivative sulfatide is also in abundance present (together with a small group of proteins)...

Cerebrosides have a single glucose or galactose at the 1-hydroxy position. Sulfatides are sulfated cerebrosides. Gangliosides have at least three sugars, one...

(1989). "Antistasin, an inhibitor of coagulation and metastasis, binds to sulfatide (Gal(3-SO4) beta 1-1Cer) and has a sequence homology with other proteins...

of the charge carrier. While in gangliosides sialic acids are found, sulfatides have a sulfate group. The structural similarity of most glycolipids is...

(RESIDUES 400-408) 1onq: Crystal Structure of CD1a in Complex with a Sulfatide 1p7q: Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC...

cleft) and TCR binds to the A’ binding pocket (the left side of CD1a). Sulfatide and sphingomyelin can be considered antagonists for CD1 autoreactive cells...

expected to start producing the ARSA enzyme that breaks down the build-up of sulfatides in the nerve cells and other cells of the patient's body. Libmeldy was...

Tay–Sachs Metachromatic leukodystrophy (MLD) Arylsulfatase A or prosaposin Sulfatide compounds in neural tissue Demyelination in CNS and PNS: Mental retardation...

with glucose as the saccharide moiety; often found in non-neural tissue. Sulfatides: a class of glycolipids containing a sulfate group in the carbohydrate...

surface protein, filamentous haemagglutinin adhesin, which binds to the sulfatides found on cilia of epithelial cells. Other adhesins are fimbriae and petractin...

NKT cells. Some type II NKT cells recognize the mammalian glycolipid sulfatide (produced at high concentrations in neuroendocrine tissue) phospholipid...

lactosylceramide. Cerebrosides containing a sulfuric ester (sulfate) group, known as sulfatides, also occur in the myelin sheath of nerves. These compounds are preferably...

polycyclic aromatic hydrocarbons). Sulfate is part of sulfolipids, such as sulfatides, which constitute 20% of the galactolipids in myelin. Another example...

sulfatides. During her doctoral research, Lees identified that it was possible to extract sulfatide using chloroform. and that extracts of sulfatide including...

thesis concerned the blood lipids in diabetics. In 1933 he discovered that sulfatide in the brain contained amide-bound fatty acid and 4-sphingenine. Along...

ontology Molecular function growth factor activity RNA binding lipid binding sulfatide binding Cellular component nucleus extracellular region extracellular...

X-ray crystallography combined with biological assays, that endogenous sulfatides are capable of binding to the TLR4-MD2 complex, causing its activation...

produce the ARSA enzyme, which helps break down the harmful build-up of sulfatides and may stop the progression of MLD. Prior to treatment, recipients must...

2007). "P-selectin mediates metastatic progression through binding to sulfatides on tumor cells". Glycobiology. 17 (2): 185–96. doi:10.1093/glycob/cwl059...

v t e PDB gallery 1onq: Crystal Structure of CD1a in Complex with a Sulfatide 1xz0: Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide...

Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans...

spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR...