Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable...

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene. Synaptotagmins are integral membrane proteins of synaptic vesicles thought to...

Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene. GRCh38: Ensembl release 89: ENSG00000117868 – Ensembl, May 2017 GRCm38:...

fusing membranes. Synaptotagmin has been recognized as the major sensor for Ca2+ triggered exocytosis in animals. However, synaptotagmin proteins are absent...

Synaptotagmin XIV is a protein that in humans is encoded by the SYT14 gene. This gene is a member of the synaptotagmin gene family and encodes a protein...

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene. GRCh38: Ensembl release 89: ENSG00000129990 – Ensembl, May 2017 GRCm38: Ensembl...

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene. Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins...

Synaptotagmin-11 is a protein that in humans is encoded by the SYT11 gene. SYT11 has been shown to interact with Parkin (ligase). GRCh38: Ensembl release...

gradient. Calcium goes on to stimulate exocytosis via binding with synaptotagmin 1. SNAP-25 however, has been shown to negatively regulate VGCC function...

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene. Synaptotagmins, such as SYT6, share a common domain structure that includes a...

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene. SYT13 belongs to the large synaptotagmin protein family. All synaptotagmins...

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene. GRCh38: Ensembl release 89: ENSG00000143858 – Ensembl, May 2017 GRCm38: Ensembl...

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene. SYT9 has been shown to interact with SYNCRIP, TUBB and TRPV1. GRCh38: Ensembl...

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene. GRCh38: Ensembl release 89: ENSG00000132872 – Ensembl, May 2017 GRCm38: Ensembl...

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene. GRCh38: Ensembl release 89: ENSG00000213023 – Ensembl, May 2017 GRCm38: Ensembl...

synaphin 1 and 2. In the presence of Ca2+, the transport vesicle protein synaptotagmin displaces complexin, allowing the SNARE protein complex to bind the...

stroke of the action potential (tail current). Calcium ions then bind to synaptotagmin proteins found within the membranes of the synaptic vesicles, allowing...

Baker-Gordon syndrome, is a rare genetic disorder caused by mutations in the synaptotagmin-1 (SYT1) gene. Patients present with neurodevelomental impairments and...

presynaptic membrane. Ca2+ binds to specific proteins, one of which is Synaptotagmin, in neurons which triggers the complete fusion of the vesicle with the...

Extended synaptotagmin-1 is a protein in humans that is encoded by the ESYT1 gene. GRCh38: Ensembl release 89: ENSG00000139641 – Ensembl, May 2017 GRCm38:...

Synaptotagmin-like 2, also known as SYTL2, is a human gene. The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2...

began with the discovery of synaptotagmins and their role in neurotransmitter release from the presynaptic neuron. Synaptotagmin, a transmembrane protein...

recognize distinct classes of receptors simultaneously (gangliosides, synaptotagmin and SV2). Once inside the cytoplasm, the toxin cleaves SNARE proteins...

Antibodies may also bind other VGCCs. Some have antibodies that bind synaptotagmin, the protein sensor for calcium-regulated vesicle fusion. Many people...

"Inhibition of Neurotransmitter Release by C2-domain Peptides Implicates Synaptotagmin in Exocytosis". Nature. 363 (6425): 163–165. doi:10.1038/363163a0. PMID 8097867...

S Evans; Zhao Wang; Sung E Kwon; Edwin Chapman (25 February 2014). "Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment". eLife...

trigger for this event is the calcium-binding synaptic vesicle protein synaptotagmin. The ability of SNAREs to mediate fusion in a calcium-dependent manner...

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene. GRCh38: Ensembl release 89: ENSG00000102362 – Ensembl, May 2017...

calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmins) on synaptic vesicles, triggering vesicle fusion with the cell membrane...

vesicle fusion. This cell line has been used to understand the role of synaptotagmin in vesicle-cell membrane fusion. Their embryological origin with neuroblastic...