• Thumbnail for Thalidomide
    Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers (e.g., multiple myeloma)...
    76 KB (7,445 words) - 12:13, 13 January 2025
  • Thumbnail for Thalidomide scandal
    In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant...
    40 KB (4,058 words) - 10:37, 17 December 2024
  • Thumbnail for Phocomelia
    cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined...
    18 KB (2,035 words) - 18:35, 11 November 2024
  • Chemical agents Prescription and recreational drugs (e.g., alcohol, thalidomide) Environmental toxins and contaminants (e.g., heavy metals such as mercury...
    44 KB (4,843 words) - 14:36, 13 January 2025
  • Thumbnail for Cereblon E3 ligase modulator
    immune responses) containing an imide group. The IMiD class includes thalidomide and its analogues (lenalidomide, pomalidomide, mezigdomide and iberdomide)...
    49 KB (5,487 words) - 15:05, 12 January 2025
  • Thumbnail for Frances Oldham Kelsey
    the U.S. Food and Drug Administration (FDA), she refused to authorize thalidomide for market because she had concerns about the lack of evidence regarding...
    33 KB (3,044 words) - 13:13, 27 November 2024
  • considered a side effect. For information regarding birth defects, see thalidomide. Somnolence (drowsiness; ~40%) Edema (~60%) Hypotension (low blood pressure)...
    3 KB (187 words) - 15:46, 26 July 2023
  • 1962) is an English thalidomide survivor and activist. She is a past chair of the National Advisory Committee of the Thalidomide Trust, the organisation...
    4 KB (269 words) - 04:20, 28 July 2024
  • Thumbnail for Grünenthal
    the teratogenic drug thalidomide, marketed as the sleeping pill Contergan and promoted as a morning sickness preventive. Thalidomide caused severe birth...
    23 KB (2,304 words) - 23:20, 31 August 2024
  • example of the importance of stereochemistry relates to the thalidomide disaster. Thalidomide is a pharmaceutical drug, first prepared in 1957 in Germany...
    11 KB (1,192 words) - 23:13, 28 December 2024
  • Canadian paralympic gold medallist swimmer, and thalidomide survivor. She was president of the Thalidomide Victims Association of Canada in 2019. Lake was...
    6 KB (400 words) - 15:51, 5 January 2025
  • Wonder Drug: The Secret History of Thalidomide in America and Its Hidden Victims is a nonfiction book authored by Jennifer Vanderbes and published by...
    5 KB (274 words) - 04:37, 26 March 2024
  • Thumbnail for Mat Fraser (actor)
    English rock musician, actor, writer and performance artist. He has thalidomide-induced phocomelia. Between 1980 and 1995 Fraser was a drummer with several...
    17 KB (1,629 words) - 03:07, 15 November 2024
  • Thumbnail for Lorraine Mercer
    a British thalidomide survivor, painter, lace maker, and carriage driver with the RDA. Mercer was a representative of the global thalidomide community...
    3 KB (175 words) - 11:19, 11 September 2024
  • Australian obstetrician. He published a letter on the teratogenicity of thalidomide following the findings of a midwife named Pat Sparrow, which resulted...
    8 KB (718 words) - 11:08, 20 August 2024
  • Thalidomide!! A Musical is a British musical written and composed by Mat Fraser, who was born with phocomelia as a result of the drug thalidomide being...
    3 KB (232 words) - 15:20, 24 December 2024
  • Thumbnail for Lenalidomide
    adjusted in people with kidney problems. Lenalidomide is closely related to thalidomide, which is known to cause severe birth defects, so its use during pregnancy...
    29 KB (2,483 words) - 16:59, 12 January 2025
  • Thumbnail for Developmental toxicity
    deficiency), drugs (e.g. anticancer drugs, tetracyclines, many hormones, thalidomide), and environmental chemicals (e.g. mercury, lead, dioxins, PBDEs, HBCD...
    27 KB (3,260 words) - 15:19, 12 January 2025
  • Thumbnail for Enantioselective synthesis
    following the thalidomide disaster the development and licensing of drugs changed dramatically. First synthesized in 1953, thalidomide was widely prescribed...
    41 KB (4,726 words) - 05:21, 27 May 2024
  • thalidomide was first made available on 1 October 1957, and it became the second best-selling medication in Germany after Bayer Aspirin. Thalidomide was...
    3 KB (284 words) - 21:38, 15 July 2024
  • wildly in their pharmacokinetic, pharmacodynamic profile. The tragedy of thalidomide illustrates the potential for extreme consequences resulting from the...
    41 KB (4,547 words) - 13:45, 15 August 2024
  • gain support for the survivors of thalidomide. Her efforts resulted in life-time compensation for Canadian "thalidomiders", as well as a special fund for...
    10 KB (932 words) - 02:00, 4 November 2024
  • Thumbnail for Cereblon
    activity of thalidomide in the chick and zebrafish was cast into doubt due to a 2013 report that pomalidomide (a more potent thalidomide analogue) does...
    12 KB (1,350 words) - 18:40, 2 November 2024
  • 1939) is a London art dealer and Thalidomide parent activist. He is the father of a daughter, Louise, disabled by thalidomide. Mason was educated at Highgate...
    11 KB (489 words) - 06:08, 1 January 2025
  • Thumbnail for Pomalidomide
    compound of pomalidomide, thalidomide, was originally discovered to inhibit angiogenesis in 1994. Based upon this discovery, thalidomide was taken into clinical...
    18 KB (1,271 words) - 05:12, 14 January 2025
  • the other enantiomer is harmful, like salbutamol and thalidomide. The (R) enantiomer of thalidomide is effective against morning sickness, while the (S)...
    15 KB (1,826 words) - 06:36, 30 November 2024
  • "Mikey" Argy, who was born with shortened arms due to a birth defect from thalidomide, a sleeping pill developed in Germany. Michaelina was awarded an MBE...
    13 KB (1,207 words) - 13:33, 16 January 2025
  • rather than by sound. Taussig is also known for her work in banning thalidomide and was widely recognized as a highly skilled physician. She was the...
    36 KB (4,116 words) - 11:15, 11 January 2025
  • Thumbnail for Multiple myeloma
    are the major side effects of thalidomide and lenalidomide. Lenalidomide causes more myelosuppression, and thalidomide causes more sedation. Chemotherapy-induced...
    131 KB (13,509 words) - 07:10, 8 January 2025
  • Thumbnail for Kefauver–Harris Amendment
    response to the thalidomide tragedy, in which thousands of children were born with birth defects as a result of their mothers taking thalidomide for morning...
    9 KB (713 words) - 07:30, 9 December 2024