Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres...

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase...

the University of California, Santa Cruz. Greider discovered the enzyme telomerase in 1984, while she was a graduate student of Elizabeth Blackburn at the...

Salk Institute for Biological Studies. In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. For...

discovery of how chromosomes are protected by telomeres and the enzyme telomerase. During DNA replication, DNA polymerase cannot replicate the sequences...

to activate telomerase more than any other known compound yet discovered: 8.8-fold. This exceeds the activation by other known telomerase activators:...

Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres...

Greider, and Jack Szostak in the 1980s led to the successful discovery of telomerase (the enzyme responsible for maintaining telomere length) and a better...

developing and commercializing therapeutic products for cancer that inhibit telomerase. Geron, based in Foster City, California, was founded by gerontologist...

transfusion-dependent anemia. Imetelstat is an oligonucleotide telomerase inhibitor. By blocking telomerase activity, imetelstat causes telomere shortening, inhibits...

to telomerase, an enzyme that repairs long repetitive sections of DNA sequences at the ends of chromosomes, referred to as telomeres. Telomerase is expressed...

disorders short telomeres can cause. It is thought that without functional telomerase, chromosomes will likely be attached together at their ends through the...

Retroelements not elsewhere classified Retron Diversity-generating retroelement Telomerase reverse transcriptase Reverse transcriptase-related cellular gene Ribozyme...

reversing it. Cultures not containing telomerase-active pluripotent stem cells would have been populated with telomerase-inactive cells, which would have been...

various legume species in the genus Astragalus that is purported to have telomerase activation activity. A preliminary in vitro study on human CD4 and CD8...

Retroelements not elsewhere classified Retron Diversity-generating retroelement Telomerase reverse transcriptase Reverse transcriptase-related cellular gene Ribozyme...

area of research, it is generally believed to play a role in regulating telomerase activity as well as maintaining the heterochromatic state at the ends...

that was the first to successfully identify the genes for human enzyme telomerase. This enzyme is responsible for preventing telomeres from shortening in...

Retroelements not elsewhere classified Retron Diversity-generating retroelement Telomerase reverse transcriptase Reverse transcriptase-related cellular gene Ribozyme...

cells. Like many other cancer cells, HeLa cells have an active version of telomerase during cell division, which copies telomeres over and over again. This...

two associated vault proteins, TEP1 and VPARP. TEP1, also known as the telomerase-associated protein 1, is 290 kDa and VPARP (also known as PARP4) is related...

Ateganosine is a telomerase inhibitor and apoptosis inducer currently under investigation for the treatment of various cancers, including non-small cell...

reactions. He also studied telomeres, and his lab discovered an enzyme, TERT (telomerase reverse transcriptase), which is part of the process of restoring telomeres...

Retroelements not elsewhere classified Retron Diversity-generating retroelement Telomerase reverse transcriptase Reverse transcriptase-related cellular gene Ribozyme...

to telomerase, an enzyme that repairs long repetitive sections of DNA sequences at the ends of chromosomes, referred to as telomeres. Telomerase is expressed...

the activity of the protein telomerase for their immortality, it has been proposed that a drug that inactivates telomerase might be effective against a...

PIN2/TERF1-interacting telomerase inhibitor 1, also known as PINX1, is a human gene. PINX1 is also known as PIN2 interacting protein 1. PINX1 is a telomerase inhibitor...

involved breeding genetically manipulated mice that lacked an enzyme called telomerase, causing the mice to age prematurely and suffer ailments. When the mice...

Epitalon is a synthetic peptide, telomerase activator, and putative anti-aging compound, which was identified as the putative active component of a bovine...

Retroelements not elsewhere classified Retron Diversity-generating retroelement Telomerase reverse transcriptase Reverse transcriptase-related cellular gene Ribozyme...