Thiolactones are a class of heterocyclic compounds in organic chemistry. They are analogs of the more common lactones in which an oxygen atom is replaced...

Homocysteine thiolactone (HTL) is an organosulfur compound with the formula H2NCHC(O)SCH2CH2. It is the thiolactone (intramolecular thioester) of homocysteine...

for methionine synthase. Homocysteine can cyclize to give homocysteine thiolactone, a five-membered heterocycle. Because of this "self-looping" reaction...

intestine and carboxylesterase 1 in the liver to a likewise inactive thiolactone, which is then converted by CYP3A4 and CYP2B6, and to a minor extent...

CYP2C19, CYP2C9, CYP2B6, and CYP3A. The thiophene ring is converted to a thiolactone, which undergoes ring-opening. The active metabolite has three sites...

acid: a novel mucolytic agent of the class of homocysteine thiolactone derivatives". Il Farmaco; Edizione Scientifica. 41 (1): 69–79. PMID 3956722...

A/B-corrin-ring closure was also achieved by converting the thiolactone-thiolactame intermediate HE-40u to thiolactone-thioiminoester HE-45u by S-methylation of the...

protein for degradation. Oxidation of the sulfur atom in thioesters (thiolactones) is postulated in the bioactivation of the antithrombotic prodrugs ticlopidine...

biological function is hydrolysis of the reactive electrophile homocysteine thiolactone. Another of its activities is metabolic inactivation of the glycopeptide...

transcriptional quorum-sensing (QS) system activated by an autoinducing, thiolactone-containing cyclic peptide (AIP). Agr occurs in 4 allelic subtypes that...

to the thiolactone intermediate 1. Shimizu and Seki realized the efficient synthesis of (+)-biotin via the Fukuyama coupling of the thiolactone 1 and an...

especially when exposed to light (due to both the furan ring and the thiolactone group in the molecule). Kadethrin at Sigma-Aldrich John E. Casida (1980)...

(+)-biotin. In this case, the Fukuyama coupling takes place with the thiolactone: The Barbier reaction involves nucleophilic addition of a carbanion equivalent...

starts in the intestines where it is metabolized by esterase into a thiolactone, this inactive intermediate then undergoes CYP-mediated ring opening...

hydrolysing a wide variety of substrates, such as lactones, including thiolactones and pharmaceutical agents such as statins. PON1 substrates also include...

Citiolone is a drug used in liver therapy. It is a derivative of the amino acid cysteine. Citilone has also been studied with regards to hypothermia due...