Thiolated polymers – designated thiomers – are functional polymers used in biotechnology product development with the intention to prolong mucosal drug...

can be introduced. Another example are thiolated polysaccharides ( see thiomers). Thiol groups are covalently attached to polysaccharides such as hyaluronic...

three-dimensional tissue formation. Furthermore, thiolated xanthan gum (see thiomers) has shown potential for drug delivery, since by the covalent attachment...

polymers (=thiomers) can form disulfide bridges with cysteine substructures of keratins getting covalently attached to these proteins. Thiomers exhibit therefore...

and mucoadhesive properties can be introduced. The thiolated polymer (thiomer) forms disulfide bonds within its polymeric network and with cysteine-rich...

enhancing properties can be introduced. Thiolated cellulose derivatives (see thiomers) exhibit also high binding properties for metal ions. Cellulose for industrial...

Thiolated pectin exhibits substantially improved gelling properties since this thiomer is able to crosslink via disulfide bond formation. These high gelling properties...

molecules into a host. Hyaluronan can be crosslinked by attaching thiols (see thiomers) (trade names: Extracel, HyStem), hexadecylamides (trade name: Hymovis)...

cells to grow into the dressing. Furthermore, thiolated chitosans (see thiomers) are used for tissue engineering and wound healing, as these biopolymers...

Sündermann N, Prüfert F, Suchaoin W, et al. (December 2016). "Preactivated thiomers for intranasal delivery of apomorphine: In vitro and in vivo evaluation"...

polymers) (physical gels) or chemical bonds such as disulfide bonds (see thiomers) (chemical gels), as well as crystallites or other junctions that remain...

mucoadhesive properties can be introduced as these thiolated oligomers (thiomers) are capable of forming disulfide bonds with cysteine-rich subdomains of...

contain reversible covalent cross-linking bonds, such as hydrogels of thiomers being cross-linked via disulfide bonds, are non-toxic and are used in numerous...

crosslink via disulfide bond formation. The use of thiolated polymers (thiomers) as scaffold material for tissue engineering was initially introduced at...

their ocular residence time can be even improved, as thiolated polymers (thiomers) form disulfide bonds with cysteine-rich subdomains of mucus glycoproteins...

disulfide bonds are likely most important. Thiolated polymers – designated thiomers – are mucoadhesive polymers that can form disulfide bonds with cysteine-rich...

Furthermore, thiolation of proteins and carbohydrates enables these polymers (thiomers) to covalently adhere especially to cysteine-rich subdomains of proteins...

of thiol groups on the surface of nanoparticles or by coating them with thiomers high (muco)adhesive and cellular uptake enhancing properties can be introduced...

mucoadhesive and in situ gelling polymers and thiolated cyclodextrins (see thiomers). Besides the logistical problems associated with using topicals, there...

to induce their self-assembly into nanogels. When thiolated polymers (thiomers) are used for this preparation process, nanogels can be further stabilized...

technologies, such as thiolated polymers, for which he coined the name thiomers in 2000, and phosphatase triggered charge-converting nanoparticles for...

Studies have also found that the modification of chitosan formulations with thiomers, which can form covalent bonds with mucus, can significantly improve the...