Transthyretin (TTR or TBPA) is a transport protein in the plasma and cerebrospinal fluid that transports the thyroid hormone thyroxine (T4) and retinol...

Familial amyloid polyneuropathy, also called transthyretin-related hereditary amyloidosis, transthyretin amyloidosis abbreviated also as ATTR (hereditary...

Wild-type transthyretin amyloid (WTTA), also known as senile systemic amyloidosis (SSA), is a disease that typically affects the heart and tendons of...

dialysis-related (Aβ2M), and hereditary and old age (ATTR and wild-type transthyretin amyloid). Diagnosis may be suspected when protein is found in the urine...

familial transthyretin mutations, liver transplantation can provide the body with a source of normal transthyretin. By changing the source of transthyretin from...

medication used for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults. It is a double stranded small...

the quaternary structure of the protein transthyretin. In people with transthyretin amyloidosis, transthyretin falls apart and forms clumps called (amyloid)...

used for the treatment of polyneuropathy in people with hereditary transthyretin-mediated amyloidosis, a fatal rare disease that is estimated to affect...

of transthyretin-mediated amyloidosis. It is a transthyretin-directed antisense oligonucleotide. It was developed to treat hereditary transthyretin amyloidosis...

Acoramidis (AG10) is an investigational transthyretin stabilizer developed to treat transthyretin amyloid cardiomyopathy. It is delivered by mouth. An...

(FAC), or transthyretin amyloid cardiomyopathy (ATTR-CM) results from the aggregation and deposition of mutant and wild-type transthyretin (TTR) protein...

hypercholesterolemia. Inotersen received FDA approval for the treatment of hereditary transthyretin-mediated amyloidosis in October 2018. The application for inotersen...

many amyloidogenic proteins, especially immunoglobulin light chain or transthyretin (TTR). It can be characterized by the extracellular deposition of amyloids...

hormones in circulation. It is one of three transport proteins (along with transthyretin and serum albumin) responsible for carrying the thyroid hormones thyroxine...

or mutation in the transthyretin (TTR) gene which is inherited. Changing just one amino-acid changes the tetrameric transthyretin proteins, resulting...

medication used for the treatment of nerve damage in adults with hereditary transthyretin-mediated amyloidosis. The sequence is TCTTG GTTACATGAA ATCCC, where...

glycogen storage disease type II. In transthyretin-related hereditary amyloidosis, the liver produces a mutated transthyretin protein which has severe neurodegenerative...

transthyretin amyloidogenesis-associated polyneuropathy should probably be considered first. "FAP-I" and "FAP-II" are associated with transthyretin....

proteins decrease in inflammation. Examples include albumin, transferrin, transthyretin, retinol-binding protein, antithrombin, transcortin. The decrease of...

Examples of specific blood proteins:[citation needed] Prealbumin (transthyretin) Alpha 1 antitrypsin (neutralizes trypsin that has leaked from the digestive...

formed a partnership with Sanofi Genzyme to develop a treatment for transthyretin-mediated amyloidosis, a hereditary disease in Asia.[third-party source...

Tafamidis (Vyndaqel, Vyndamax) Transthyretin chaperone (stabilizer) Familial amyloid polyneuropathy and other transthyretin amyloidoses 2011 2019 Voxelotor...

the light chain protein that forms amyloid in various bodily organs. Transthyretin (TTR) amyloidosis (ATTR) results from the deposition of misfolded TTR...

involving RNA therapy to block the production of an abnormal form of transthyretin. Patisiran received full FDA approval in 2018 and its RNA lipid nanoparticle...

around the bloodstream. Examples include: Thyroxine-binding globulin Transthyretin Serum albumin Thyroxine-binding+proteins at the U.S. National Library...

trafficking of ΔF508 CFTR to the plasma membrane. Partially denatured transthyretin (TTR) can promote the formation of amyloid fibrils in cells, and this...

the blood. Most are bound to thyroxine-binding globulin (about 70%), transthyretin (10%), and albumin (15%). Only the 0.03% of T4 and 0.3% of T3 traveling...

Tonopah Test Range, a military installation in Nevada, United States Transthyretin, a plasma protein Trans-Tasman Resources, an Australian-owned mining...

includes CA-125, beta-2 microglobulin, transferrin, apolipoprotein A1, and transthyretin. OVA1 above 5.0 in premenopausal women and 4.4 in postmenopausal women...

Tafamidis or Vyndaqel (a kinetic stabilizer of tetrameric transthyretin) for the treatment of transthyretin amyloid diseases. This suggests that the process of...