U.S. Route 21 or U.S. Highway 21 (US 21) is a north–south United States Numbered Highway, spanning 393 miles (632 km) from Hunting Island State Park,...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

U.S. Route 211 (US 211) is a spur of US 11 in the U.S. state of Virginia. Known for most of its length as Lee Highway, the U.S. Highway runs 59.09 miles...

U.S. Route 521 (US 521) is a north–south United States Highway that traverses 177.3 miles (285.3 km), from Georgetown, South Carolina, to Charlotte, North...

U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) was one of the original highways in the United States Numbered Highway System. It was established...

Several special routes of U.S. Route 21 (US 21) exist. In order from south to north, they are as follows. U.S. Highway 21 Business (US 21 Bus.) is a 5.400-mile...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

U.S. Route 121 (US 121) is a proposed U.S. highway designated as the Coalfields Expressway, a four-lane highway stretching from Beckley, West Virginia...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

U.S. Route 99 (US 99) was a main north–south United States Numbered Highway on the West Coast of the United States until 1964, running from Calexico,...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America (a nickname shared with U.S. Route 66), is a major east–west United...

U.S. Route 31E (US 31E) is the eastern parallel route for U.S. Highway 31 from Nashville, Tennessee, to Louisville, Kentucky. US 31E begins as the Ellington...

U.S. Route 385 (US 385) is a spur of U.S. Route 85 that runs for 1,206 miles (1,941 km) from Deadwood, South Dakota to Big Bend National Park in Texas...

U.S. Route 167 is a north-south United States Highway within the U.S. states of Louisiana and Arkansas. It runs for 500 miles (800 km) from Ash Flat, Arkansas...

U.S. Route 371 is a north–south United States highway in the U.S. states of Arkansas and Louisiana. The highway's northern terminus is in De Queen, Arkansas...

U.S. Route 1 or U.S. Highway 1 (US 1) is a major north–south United States Numbered Highway that serves the East Coast of the United States. It runs 2...

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 280 (US 280) is a spur of U.S. Highway 80. It currently runs for 392 miles (631 km) from Blitchton, Georgia, at US 80 to Birmingham, Alabama...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 202 (US 202) is a spur route of US 2. It follows a northeasterly and southwesterly direction stretching from Delaware in the south to Maine...

U.S. Route 56 (US 56) is an east–west United States highway that runs for approximately 640 miles (1,030 km) in the Midwestern United States. US 56's...

U.S. Route 466 (US 466) was an east–west United States highway. Though it reached a length of around 500 miles (805 km), the route was co-signed with other...

U.S. Route 58 (US 58) is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S...

U.S. Route 550 (US 550) is a spur of U.S. Highway 50 that runs from Bernalillo, New Mexico to Montrose, Colorado in the western United States. The section...

U.S. Route 491 (US 491) is a north–south U.S. Highway serving the Four Corners region of the United States. It was created in 2003 as a renumbering of...