BRCA2 and BRCA2 (/ˌbrækəˈtuː/) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for...

A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these...

or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. BRCA1 and BRCA2 have...

or ovaries, or sex steroid-responsive genes. Breast cancer caused by the BRCA2 mutation is an example of a disease with gender-related penetrance. The...

whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the classifier...

homologous recombination. The well-known cancer susceptibility genes BRCA1 and BRCA2 are also examples of FA genes (FANCS and FANCD1 respectively), and biallelic...

related to inherited genetic risk; women with mutations in the genes BRCA1 or BRCA2 have about a 50% chance of developing the disease. Some family cancer syndromes...

cancer gene, BRCA2, and related proteins cause genome instability to trigger carcinogenesis. His work has helped to explain why carriers of BRCA2 mutations...

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene. This gene encodes a protein that...

cancer, such as p53, BRCA1 and BRCA2, occur in mechanisms to correct errors in DNA. The inherited mutation in BRCA1 or BRCA2 genes can interfere with repair...

suppressing BRCA2 gene), which can increase the risk of a woman developing ovarian cancer to as high as 65% (as high as 25% for a mutated BRCA2 gene). List...

related families. Mutations in BReast CAncer 1 (BRCA1) and BReast CAncer 2 (BRCA2) are significantly related. The lifetime risk of a female developing breast...

new name references Mary-Claire King who identified the genes BRCA1 and BRCA2. Most hereditary breast-ovarian cancer syndromes are inherited in an autosomal...

Frequency of mutations on BRCA2 gene on chromosome 13...

cancer, such as individuals who may have pathogenic variants of the BRCA1 or BRCA2 gene. Originally salpingectomy was used in cases of ectopic pregnancies...

tumor suppressors include pVHL, APC, CD95, ST5, YPEL3, ST7, and ST14, p16, BRCA2. Anticancer gene Metastasis suppressor Adenomatosis polyposis coli Oncogene...

both BRCA1 and BRCA2. Many breast cancers have defects in the BRCA1/BRCA2 HR repair pathway due to mutations in either BRCA1 or BRCA2, or other essential...

gene 2 (BRCA2) is employed in homologous recombinational repair of DNA damages during meiosis. A common single-nucleotide polymorphism of BRCA2 is associated...

these syndromes include: certain inherited mutations in the genes BRCA1 and BRCA2 with a more than 75% risk of breast cancer and ovarian cancer, and hereditary...

DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers. In...

from BRCA2 mutation carriers. These findings showed that cells lacking functional BRCA2 protein are prone to DNA damage and suggest that BRCA2 has a...

the BRCA2 complex primarily mediates orderly assembly of RAD51 on ssDNA, which is an active substrate in homologous pairing and strand invasion. BRCA2 also...

single-strand breaks generated by the radiotherapy in tumor tissue with BRCA1/BRCA2 mutations. This combination could therefore lead to either more powerful...

known function of BRCA2 is to help initiate homologous recombination, researchers have speculated that more detailed knowledge of BRCA2's role in homologous...

women who have tested positive for a deleterious mutation on the BRCA1 or BRCA2 gene and opt for a preventive mastectomy since they are at high risk for...

cancer, particularly those who inherit cancer-associated variants of the BRCA2 gene. Each year 1.2 million cases of prostate cancer are diagnosed, and...

autosomal recessive ATM and autosomal dominantly inherited mutations in the BRCA2 and PALB2 genes; hereditary non-polyposis colon cancer (Lynch syndrome);...

damage. BRCA2 is believed to be involved in homologous recombination and regulating the S-phase checkpoint, and mutations of deficiencies in BRCA2 are strongly...

Oostrom CT, Ross GM, van Steeg H, Ashworth A (March 2002). "Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing...

recommendations for screening. These include those who: Have a known BRCA1 or BRCA2 gene mutation. Have a 1st-degree relative (parent, brother, sister, or child)...