major prion protein (PrP) is encoded in the human body by the PRNP gene also known as CD230 (cluster of differentiation 230). Expression of the protein is...

A prion /ˈpriːɒn/ is a misfolded protein that induces misfolding in normal variants of the same protein, leading to cellular death. Prions are responsible...

animal with no prion protein mutation. Inherited TSE occurs in animals carrying a rare mutant prion allele, which expresses prion proteins that contort...

abnormal folding of a protein known as a prion. Infectious prions are misfolded proteins that can cause normally folded proteins to also become misfolded...

of a host-encoded protein called prion (PrP). Prion proteins are encoded by the Prion Protein Gene (PRNP). The two forms of prion are designated as PrPc...

accumulation of prions in the central nervous system, and immunohistochemical staining and ELISA can also be used to demonstrate the protein. No treatment...

encephalopathies (TSE) due to the causative role played by PRNP, the human prion protein. GSS was first reported by the Austrian physicians Josef Gerstmann,...

A fungal prion is a prion that infects hosts which are fungi. Fungal prions are naturally occurring proteins that can switch between multiple, structurally...

rare hereditary prion disease that is associated with a mutation in PRNP. The gene, which provides instructions for making the prion protein PrPC, is located...

following the onset of symptoms is 13 months. It is caused by prions, which are misfolded proteins. Spread is believed to be primarily due to eating beef infected...

TSEs are a family of diseases thought to be caused by misfolded proteins called prions and include similar diseases such as BSE (mad cow disease) in cattle...

inducible proteopathy are prion diseases, which can be transmitted by exposure of a host organism to purified prion protein in a disease-causing conformation...

globally. BSE is thought to be due to an infection by a misfolded protein, known as a prion. Cattle are believed to have been infected by being fed meat-and-bone...

stored the frozen brains of transgenic mice that overexpressed human prion protein. Despite wearing a double pair of latex gloves, the forceps cut her...

nucleic acids (DNA or RNA). Prions are mainly twisted isoforms of the major prion protein (PrP), a naturally occurring protein with an uncertain function...

Sensitive Prionopathy) is a sporadic prion protein disease first described in an abstract for a conference on prions in 2006, and this study was published...

amount of abnormal prion with an excess of normal protein, so that some conversion takes place. The growing chain of misfolded protein is then blasted with...

The prion pseudoknot is predicted RNA pseudoknot structure found in prion protein mRNA. It has been suggested that this element has a possible effect...

normally folded prions, often a truncated Syrian Hamster protein, amino acids 90-231. Samples suspected of containing misfolded prions are added, leading...

a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like...

Prion protein 2 (dublet), also known as PRND, or Doppel protein, is a protein which in humans is encoded by the PRND gene. This gene is found on chromosome...

Prion protein and antibodies POM1 and POM3, which recognize epitopes in the terminus (around amino acids (aa) 140–152) and charged clusters of prion protein...

for protein or other food. Kuru is a type of transmissible spongiform encephalopathy (TSE) caused by prions that are found in humans. Human prion diseases...

infectious it is not considered to be a true prion but instead a "prion-like" protein. Much like true prions, pathological tau aggregates have been shown...

"Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein". Journal of Medicinal Chemistry. 46 (17): 3563–3564. doi:10.1021/jm034093h...

colleagues were the first to show that prion protein amyloid was derived from a glycosylated 34kd precursor protein using lectins. PrP antibodies and selected...

(2002) Guanidine hydrochloride inhibits the generation of prion "seeds" but not prion protein aggregation in yeast. Mol Cell Biol 22 (15):5593-5605. Eaglestone...

disease-associated form of the prion protein (PrPSc), resulting from a conformational change of the normal (cellular) form of prion protein (PrPC), is considered...

and affecting the type of symptoms that develop. This gene produces prion protein, which is active in the brain and other tissues and also appears to...

Fungal prion, a prion that infects fungal hosts Prion protein, the human gene encoding for the major prion protein PrP (for prion protein) Prion diseases...