Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol)...
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(mBC) in patients who have been treated previously with trastuzumab and a taxane (paclitaxel or docetaxel), and who have already been treated for mBC or...
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In enzymology, a taxane 10beta-hydroxylase (EC 1.14.13.76) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-yl acetate + NADPH...
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Docetaxel (category Taxanes)
liver problems. Use during pregnancy may harm the baby. Docetaxel is in the taxane family of medications. It works by disrupting the normal function of microtubules...
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In enzymology, a taxane 13alpha-hydroxylase (EC 1.14.13.77) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-ol + NADPH + H+...
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Abeotaxane (redirect from Abeo-taxane)
paclitaxel or docetaxel. The core carbon skeleton of a normal natural product taxane (e.g., paclitaxel, docetaxel) has a 6-membered A ring, 8-membered B ring...
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Cabazitaxel (category Taxanes)
derivative of a natural taxoid. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.[citation needed] Cabazitaxel was developed...
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agents include taxanes and epothilones, both of which prevent cancer cells from dividing by interfering with tubulin. While taxanes like Paclitaxel and...
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Paclitaxel (category Taxanes)
that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function...
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permanently in a state of assembly and disassembly. Vinca alkaloids and taxanes are the two main groups of anti-microtubule agents, and although both of...
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as the plant is a source of the class of poisonous chemicals known as taxanes, which have been a focus for cancer research. T. canadensis is much more...
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unresectable, and/or metastatic breast cancer who received prior trastuzumab and taxane therapy for metastatic disease or developed disease recurrence during or...
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breast cancer, taxane-containing chemotherapy regimens appear to improve survival and tumour shrinkage and decrease time to progression. Taxanes are associated...
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Mitotic inhibitor (section Taxanes)
molecules have generated significant interest after the introduction of the taxanes into clinical oncology and the general use of the vinca alkaloids. Examples...
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Taxamairin A is a non-taxane isolate of Taxus yunnanensis. Li SH, Zhan HJ, Yao P, Niu XM, Xiang W, Sun HD (2002). "Non-taxane compounds from the bark...
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showed it did not prevent CIPN and appeared to worsen the conditions in taxane therapy. Male infertility: Scientific reviews from 2016 and 2014 showed...
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chemotherapeutic properties. Taxoids are usually treated as synonymous with taxanes; for example, a major medical dictionary defines the two terms with the...
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advanced or metastatic breast cancer as a single agent if an anthracycline- or taxane-containing chemotherapy is not indicated; treatment of people with advanced...
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a diterpene Stemarene, a diterpene Stemodene, a diterpene Taxadiene, a taxane diterpene This set index page lists chemical structure articles associated...
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Gradishar WJ (June 2006). "Albumin-bound paclitaxel: a next-generation taxane". Expert Opinion on Pharmacotherapy. 7 (8): 1041–1053. doi:10.1517/14656566...
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epirubicin), antimetabolites (fluorouracil, capecitabine, and methotrexate), taxanes (docetaxel and paclitaxel), and platinum-based chemotherapies (cisplatin...
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Tumors that evolve resistance to docetaxel may receive the second-generation taxane drug cabazitaxel. Some CRPC treatments are used only in men whose tumors...
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AC-T may refer to: Adriamycin, cyclophosphamide, and a taxane, a combination chemotherapy regimen used to treat breast cancer Albert City–Truesdale Community...
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Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...
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drugs that can alter microtubule dynamics include: The cancer-fighting taxane class of drugs (paclitaxel (taxol) and docetaxel) block dynamic instability...
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Pavlakis N, Davey R (December 2007). "A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship" (PDF). Cancer...
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Taxine alkaloids (category Taxanes)
active. Taxine alkaloids have no medical uses but Paclitaxel and other taxanes that can be isolated from yews have been used as chemotherapy drugs. Taxine...
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concentrations, and retains activity in cases where tumor cells are insensitive to taxane type drugs. On October 16, 2007, the U.S. Food and Drug Administration approved...
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PG, Fornier MN (November 2008). "Microtubule active agents: beyond the taxane frontier". Clinical Cancer Research. 14 (22): 7167–72. doi:10.1158/1078-0432...
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