Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. For colon...
26 KB (2,315 words) - 04:55, 13 April 2024
active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro...
3 KB (225 words) - 16:48, 11 January 2024
which incorporates into the DNA molecule and stops synthesis; and IRI – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling...
4 KB (411 words) - 21:05, 6 May 2024
effectiveness to prevent diarrhea in cancer patients who have received irinotecan. It can interfere with the absorption of some medications, and lead to...
15 KB (1,215 words) - 20:28, 12 August 2024
Atropine (section Irinotecan induced diarrhea)
Europe during the Cold War. Atropine has been observed to prevent or treat irinotecan induced acute diarrhea. Adverse reactions to atropine include ventricular...
39 KB (3,656 words) - 19:56, 30 August 2024
colorectal cancer who received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type and medically...
10 KB (579 words) - 06:46, 26 June 2024
(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...
36 KB (3,299 words) - 19:46, 10 August 2024
interferes with both of these processes. Two topoisomerase I inhibitors, irinotecan and topotecan, are semi-synthetically derived from camptothecin, which...
155 KB (17,546 words) - 16:49, 16 August 2024
under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan. C. acuminata also contains the chemical compounds...
2 KB (192 words) - 22:31, 28 April 2024
(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...
31 KB (2,908 words) - 03:40, 16 September 2024
Romidepsin Vorinostat Zabadinostat Belotecan Camptothecin Exatecan Gimatecan Irinotecan Topotecan Etoposide Teniposide Tafluposide Bortezomib Erlotinib Gefitinib...
5 KB (324 words) - 12:07, 20 July 2024
chemotherapy is given the FOLFIRINOX regimen containing fluorouracil, irinotecan, oxaliplatin and leucovorin has been shown to extend survival beyond traditional...
50 KB (5,610 words) - 14:40, 4 August 2024
chemotherapeutic – cisplatin or carboplatin – combined with either etoposide or irinotecan. This is typically combined with thoracic radiation therapy – 45 Gray...
90 KB (9,784 words) - 14:55, 21 June 2024
include a combination of chemotherapy (paclitaxel and carboplatin or irinotecan plus cisplatin) and surgical resection in ovarian clear-cell carcinoma;...
3 KB (333 words) - 01:07, 3 December 2023
loperamide also include chemotherapy-induced diarrhea, especially related to irinotecan use. Loperamide should not be used as the primary treatment in cases of...
47 KB (4,106 words) - 11:29, 15 September 2024
chemotherapy regimen for rare clear-cell cancers is also under investigation: irinotecan combined with cisplatin. PARP inhibitors have also shown promise in early...
198 KB (21,176 words) - 22:22, 15 September 2024
(5-FU), up to 40% get mucositis, and 10–15% get grade 3–4 oral mucositis. Irinotecan is associated with severe GI mucositis in over 20% of patients. Seventy-five...
21 KB (2,551 words) - 07:43, 3 June 2024
cisplatin, epirubicin, etoposide, docetaxel, oxaliplatin, capecitabine, or irinotecan. The TNM staging system is also used. In a study of open-access endoscopy...
79 KB (8,199 words) - 08:50, 12 August 2024
IOHEXOL 255. IOPAMIDOL 4 256. IOMEPROL 257. IOPROMIDE 258. IRBESARTAN 259. IRINOTECAN HYDROCHLORIDE 260. IRON PREPARATION FOR PARENTERAL USE 261. ISEPAMICINE...
16 KB (253 words) - 16:47, 23 February 2023
(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...
15 KB (1,438 words) - 02:57, 10 May 2024
for a small number of drugs that are very toxic to the intestine (e.g. irinotecan), these molecules which would not otherwise be very toxic can become so...
6 KB (770 words) - 10:04, 13 September 2024
Chemotherapy drugs for this condition may include capecitabine, fluorouracil, irinotecan, oxaliplatin and UFT. The drugs capecitabine and fluorouracil are interchangeable...
145 KB (15,781 words) - 22:45, 30 August 2024
]] [[ ]] [[ ]] [[ ]] |alt=Irinotecan Pathway edit]] The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229". Glucuronosyltransferase...
14 KB (1,653 words) - 01:10, 14 November 2023
such as irinotecan. This effect is derived from the microbiome-encoded β-glucuronidase enzymes which recover the active form of the irinotecan causing...
129 KB (14,343 words) - 05:57, 9 September 2024
with severe diarrhea and neutropenia in patients who are treated with irinotecan, which is metabolized by UGT1A1. While paracetamol (acetaminophen) is...
36 KB (3,719 words) - 12:42, 16 July 2024
chlorambucil, estramustine, etoposide, flutamide, idarubicin, ifosfamide, irinotecan, ixabepilone, letrozole, lomustine, megestrol, mitomycin, mitoxantrone...
64 KB (6,621 words) - 21:00, 29 August 2024
(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...
61 KB (6,082 words) - 05:23, 17 June 2024
Aflibercept (Zaltrap), in combination with fluorouracil, leucovorin, and irinotecan (known as FOLFIRI), is indicated for the treatment of people with metastatic...
30 KB (2,151 words) - 06:03, 8 September 2024
(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...
31 KB (2,821 words) - 10:12, 17 July 2024
ways: Rotor syndrome may exacerbate toxic side effects of the medication irinotecan. Rotor syndrome is caused by mutations in two proteins responsible for...
10 KB (1,045 words) - 05:16, 13 August 2024