Proteasomes are protein complexes which degrade ubiquitin-tagged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that...

Proteasome inhibitors (INN stem –zomib) are drugs that block the action of proteasomes. Proteasomes are large proteins complexes that are used to break...

In enzymology, a proteasome ATPase (EC 3.6.4.8) is an enzyme that catalyzes the chemical reaction ATP + H2O ⇌ {\displaystyle \rightleftharpoons } ADP +...

prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn...

Proteasome accessory factor E (abbreviated PafE, also known as bacterial proteasome activator or Bpa) is an ATP-independent proteasome activator of Mycobacterium...

Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 (based on systematic nomenclature) is a protein that in humans is encoded by...

Proteasome subunit beta type-5 also known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one...

affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or...

syndrome. It is in the class of medications known as proteasome inhibitor. It works by inhibiting proteasomes, cellular complexes that break down proteins. Bortezomib...

peptides generated mainly from the degradation of cytosolic proteins by the proteasome. The MHC I: peptide complex is then inserted via the endoplasmic reticulum...

unsynthesized chemical element with atomic number 157 and symbol Ups Ubiquitin-proteasome system Ultraviolet photoelectron spectroscopy Universal Polar Stereographic...

Proteasome subunit beta type-4 also known as 20S proteasome subunit beta-7 (based on systematic nomenclature) is a protein that in humans is encoded by...

lysosome, or a ubiquitin-dependent process that targets unwanted proteins to proteasome. The autophagy-lysosomal pathway is normally a non-selective process,...

Proteasome-associated protein ECM29 homolog is a protein that in humans is encoded by the KIAA0368 gene. GRCh38: Ensembl release 89: ENSG00000136813 –...

Proteasome subunit beta type-3, also known as 20S proteasome subunit beta-3, is a protein that in humans is encoded by the PSMB3 gene. This protein is...

Proteasome maturation protein is a protein that in humans is encoded by the POMP gene. It is a short-lived maturation factor required for 20S proteasome...

and subsequent degradation by a protein-degrading complex, called the proteasome. The process of ERAD can be divided into three steps: The recognition...

greatest affinity to IgG in humans) in order to direct marked virions to the proteasome in the cytosol; IgG is also associated with type II and type III hypersensitivity...

dysfunction of the proteasome. This syndrome is caused by a mutation in the gene that encodes subunit β type-8 of the proteasome (PSMB8 gene). Due to...

an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent. carfilzomib: a proteasome inhibitor that is indicated: as a single...

chemotherapy with localized illumination and reduced adverse effects. Using proteasome-targeting technology, the MTX-PROTAC versortrexate (VSTX) selectively...

2014). "A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins...

Hsp90 and their co-chaperones, as well as by one subunit (RPT5) of the proteasome itself, that results in its folding to a catalytic conformation, which...

factors as well in activation of the insulin gene. MafA is degraded by proteasomes upon low blood glucose levels. Increased levels of glucose make an unknown...

decrease the half-life of Mei2 by making it more likely to be destroyed by a proteasome working with E2 Ubc2 and E3 Ubr1. The Mei4 transcription factor is necessary...

multiple myeloma who have received prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody...

all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway". Cancer Research. 56 (13): 2945–2948. PMID 8674046. "Retinoids...

which (among other things) can target a protein for degradation via a proteasome. This covalent bond of ubiquitin or ubiquitin-like proteins to targeted...

oligomerization state, which makes it more susceptible to destruction by the proteasome. This enzyme's activity can also be reduced by phosphorylation by an AMP-activated...

ubiquitination and subsequent degradation of the target protein via the proteasome. Because PROTACs need only to bind their targets with high selectivity...